Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea

Liu, Xianning; Wu, Jie; Wu, Zhengjie; Yi, Yin; Xiao, Xianghua; Su, Xin; Kong, Bin; Pan, Shi-Yin; Yang, Hua; Chen, Yan; An, Na; Mi, Shengli

doi:10.18240/ijo.2016.03.01

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…In most other avian species, considerably higher values can be seen than in the Common pauraque cornea (Chard & Gundlach, 1938;Collin & Collin, 2021;Gonçalves et al, 2016;Gonzalez-Alonso-Alegre et al, 2015;Liu et al, 2016;Montiani-Ferreira et al, 2004;Moraes, 2018;Murphy & Dubielzig, 1993;Sokolenko et al, 2021;Werther et al, 2017) (Table 1). Species smaller than the Common pauraque have been shown to have thinner corneas, such as in the Anna's and Black-Chinned Hummingbirds (Moore et al, 2019), and in the Japanese Quail (Mayakkannan et al, 2018) (Table 1).…”

Section: Discussionmentioning

confidence: 98%

“…Additionally, studies in most species support that the corneal periphery is thicker than the central cornea (Bergmanson, 2019, 2021; Collin & Collin, 2021; Coyo et al., 2015; Downie et al., 2021; Jones et al., 2007; Pinto et al., 2016). In most other avian species, considerably higher values can be seen than in the Common pauraque cornea (Chard & Gundlach, 1938; Collin & Collin, 2021; Gonçalves et al., 2016; Gonzalez‐Alonso‐Alegre et al., 2015; Liu et al., 2016; Montiani‐Ferreira et al., 2004; Moore & Montiani‐Ferreira, 2022; Moraes, 2018; Murphy & Dubielzig, 1993; Sokolenko et al., 2021; Werther et al., 2017) (Table 1). Species smaller than the Common pauraque have been shown to have thinner corneas, such as in the Anna's and Black‐Chinned Hummingbirds (Moore et al., 2019), and in the Japanese Quail (Mayakkannan et al., 2018) (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…The cornea plays an important role in the refraction of light onto the retina for focused image formation, and for this to occur, the cornea needs to be completely transparent (Crespo‐Moral et al., 2020; Jones et al., 2007; Martin, 2022; Nautscher et al., 2016). Transparency is afforded by the integrity of the epithelial barrier, the parallel arrangement of stromal collagen cells and relative dehydration, the relative acellularity in the stroma and the efficient active cell membrane fluid pump of the endothelium (Bergmanson, 2019; Collin & Collin, 2021; Jones et al., 2007; Liu et al., 2016; Meek & Fullwood, 2001). A healthy endothelium is represented as a monolayer of polygonal cells of relatively uniform size and shape, in which the cells are mostly hexagonal.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the common pauraque (Nyctidromus albicollis) cornea using light and scanning electron microscopy

Tozetti,

de Lima Sousa Araújo,

Moreira

et al. 2023

Anat Histol Embryol

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The common pauraque Nyctidromus albicollis (Gmelin, 1789) is a widespread avian species; however due to its nocturnal habits and reclusive behaviour, little is known about their vision and ecology. Most avian species are visually dependent with advanced visual systems providing high spatial resolution, on the species needs. Each ocular structure has a specific role in contributing towards high visual function, and the cornea is the first refractive structure in the visual process. However, the common pauraque cornea had not been described until the present data. Therefore, this study aims to describe the morphology and morphometry of the common pauraque cornea by means of light and scanning electron microscopy to evaluate the cross‐sectional anatomy as well as the ultrastructure of the endothelial cells. Histological similarities with the cornea of other birds have been observed, but the thickness of the common pauraque cornea is much smaller than the other described corneas. A better understanding of the common pauraque cornea can help us better explain the physiology of vision and the visual requirements of this species. In turn, this will help us better understand how this species successfully interacts with its environment, and will improve our knowledge on how to interpret pathological changes in their cornea in a clinical setting.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of the common pauraque (Nyctidromus albicollis) cornea using light and scanning electron microscopy

Tozetti,

de Lima Sousa Araújo,

Moreira

et al. 2023

Anat Histol Embryol

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“…Several successful techniques of xenogeneic corneal decellularization have already been described. Corneas of different species of animals (pig, cow, ostrich, rabbit, squid, dog, and cat) have been successfully used for corneal decellularization to construct the tissue-engineered corneal scaffolds [ 5 , 12 , 23 , 24 , 35 , 54 , 72 , 74 ]. Porcine corneas have been the most commonly used for corneal decellularization mainly due to their ease of availability and multiple anatomical and physiological similarities with human corneas.…”

Section: Discussionmentioning

confidence: 99%

Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature

Procházková,

Poláchová,

Dítě

et al. 2024

Journal of Ophthalmology

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The cornea is one of the most commonly transplanted tissues worldwide. It is used to restore vision when severe visual impairment or blindness occurs in patients with corneal diseases or after trauma. Due to the global shortage of healthy donor corneas, decellularized corneal tissue has significant potential as an alternative to corneal transplantation. It preserves the native and biological ultrastructure of the cornea and, therefore, represents the most promising scaffold. This article discusses different methods of corneal decellularization based on the current literature. We searched PubMed.gov for articles from January 2009 to December 2023 using the following keywords: corneal decellularization, decellularization methods, and corneal transplantation. Although several methods of decellularization of corneal tissue have been reported, a universal standardised protocol of corneal decellularization has not yet been introduced. In general, a combination of decellularization methods has been used for efficient decellularization while preserving the optimal properties of the corneal tissue.

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“…This same genome editing technique has been used to remove PERVs in vitro to obtain PERVinactivated pigs [118]. Other species that have been used to fabricate decellularized corneal scaffolds include cat [101], ostrich [119], bovine [85,120] goat [51] or dog [121]. [72][73][74]87].…”

Section: Species Used For Corneal Decellularizationmentioning

confidence: 99%

Decellularization and recellularization of cornea: Progress towards a donor alternative

Fernández‐Pérez

Ahearne

2020

Methods

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The global shortage of donor corneas for transplantation has led to corneal bioengineering being investigated as a method to generate transplantable tissues. Decellularized corneas are among the most promising materials for engineering corneal tissue since they replicate the complex structure and composition of real corneas. Decellularization is a process that aims to remove cells from organs or tissues resulting in a cell-free scaffold consisting of the tissues extracellular matrix. Here different decellularization techniques are described, including physical, chemical and biological methods. Analytical techniques to confirm decellularization efficiency are also discussed. Different cell sources for the recellularization of the three layers of the cornea, recellularization methods used in the literature and techniques used to assess the outcome of the implantation of such scaffolds are examined. Studies involving the application of decellularized corneas in animal models and human clinical studies are discussed. Finally, challenges for this technology are explored involving scalability, automatization and regulatory affairs.

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Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea

Cited by 6 publications

References 20 publications

Evaluation of the common pauraque (Nyctidromus albicollis) cornea using light and scanning electron microscopy

Evaluation of the common pauraque (Nyctidromus albicollis) cornea using light and scanning electron microscopy

Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature

Decellularization and recellularization of cornea: Progress towards a donor alternative

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