Acetaminophen and pregnancy: short- and long-term consequences for mother and child

Thiele, Kristin; Kessler, T; Arck, Petra C.; Erhardt, Annette; Tiegs, Gisa

doi:10.1016/j.jri.2012.10.014

Cited by 88 publications

(63 citation statements)

References 103 publications

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“…Additionally, recent in vitro studies as well as epidemiological studies suggest NA4AP as a possible risk factor for male developmental disorders in humans (Kristensen et al 2012, Thiele et al 2013. Therefore, in this article, we give an overview of the available data on possible detrimental effects of NA4AP on male sexual development, its role in aniline metabolism, recent HBM data, and possible sources of internal body burdens of NA4AP in the general population in environmental and occupational settings.…”

Section: Introductionmentioning

confidence: 99%

Ubiquitous presence of paracetamol in human urine: sources and implications

Modick¹,

Weiß²,

Dierkes³

et al. 2014

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N-acetyl-4-aminophenol (acetaminophen/paracetamol, NA4AP) is one of the most commonly used over-the-counter analgesic and antipyretic drugs. Recent studies have reported anti-androgenic effects of NA4AP in vitro and possible associations between intrauterine exposure to NA4AP and the development of male reproductive disorders in humans. NA4AP is also a major metabolite of aniline (phenylamine), representing 75-86% of the aniline dose excreted in urine. Aniline is an important large-volume intermediate in several industrial processes. Besides individuals in various occupational settings with aniline exposure, the general population is also known to be ubiquitously exposed to aniline. In this article, we provide an overview of the recent literature concerning the intake of NA4AP during pregnancy and the possible anti-androgenic effects of NA4AP as well as literature concerning its known metabolic precursor aniline. We also present new research data, including the first human biomonitoring data on NA4AP excretion in urine, showing ubiquitous NA4AP body burdens in the general population at a wide range of concentrations. We found a small but significant impact of smoking on urinary NA4AP concentrations. We further present preliminary data on NA4AP excretion after therapeutic acetaminophen use, after aniline exposure in an occupational setting, and during a controlled fasting study (excluding oral exposure to both aniline and acetaminophen). Our findings indicate exposure to aniline (or aniline-releasing substances) as well as nutrition (next to the direct use of acetaminophen as medication) as possible sources of internal body burdens of NA4AP.Reproduction (2014) 147 R105-R117

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Section: Introductionmentioning

confidence: 99%

Ubiquitous presence of paracetamol in human urine: sources and implications

Modick¹,

Weiß²,

Dierkes³

et al. 2014

Reproduction

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“…Exposure to endocrine disrupts during prenatal stage may affect neurodevelopment and cause behavioral dysfunction by means of snooping with hormones which are desired for normal brain growth like sex hormones, thyroid hormones. It is also possible that APAP may disrupt brain development by snooping with maternal hormones or via stimulation of oxidative stress that can increase risk of neuronal death [15].…”

Section: International Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Monster Phase of Acetaminophen Use in Pregnancy: Current Vision of an Old Drug

S.s.¹,

Swaminathan²,

Sambathkumar³

2016

Int J Pharm Pharm Sci

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In various countries, Acetaminophen [APAP] is the frequently used painkiller found in hundreds of medications during pregnancy. It has been broadly used for eras and health care professionals prefer acetaminophen as a choice during pregnancy for relieving pain and fever. Current research reports bothersome inclinations in the rate of acetaminophen exposure and related pregnancy outcome. The exposure of pregnant women to acetaminophen is of great concern. Existing literature evidence shows that acetaminophen exposure during pregnancy may leads to preterm birth, attention deficit hyperactivity disorder (ADHD), autism, male infertility, asthma in pediatrics. Therefore, the prophylactic anticipation of acetaminophen exposure can be a far-sighted approach in order to safeguard humans and wildlife from enduring dangerous effects. This article reviews the epidemiological findings and aims to shed awareness into the second generation outcome of an old drug in pregnant women.

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“…Starting at ED 7 and until delivery (day 21), mice were randomly assigned to receive either APAP per gavage (150mg/kg/day) or 0.5% carboxymethylcellulose (control). This dose was chosen since it was previously shown to have the highest serum concentrations of acetaminophen without liver toxicity in mice [6][7][8][9][10]11]. The observed mice serum concentrations at this dose were more than 10 fold higher than the measured human acetaminophen concentration after 1000 mg oral administration [6].…”

Section: Animalsmentioning

confidence: 99%