Acetaminophen, Aspirin, and Caffeine Versus Sumatriptan Succinate in the Early Treatment of Migraine: Results From the ASSET trial

Abstract

The combination of acetaminophen, aspirin, and caffeine was significantly more effective (P > .05) than sumatriptan in the early treatment of migraine, as shown by superiority in summed pain intensity difference, pain relief, pain intensity difference, response, sustained response, relief of associated symptoms, use of rescue medication, disability relief, and global assessments of effectiveness. An additional, larger clinical trial is needed to confirm these results.

Unusual Deactivation in the Asymmetric Hydrogenation of Itaconic Acid

“…The X-ray structure of a crystal obtained from a so- 2 ] BF 4 and a-methyl itaconate ( Figure 5) further supports this pathway.…”

“…The investigation of the conversion of itaconic acid 2 ] BF 4 at ambient temperature under an argon atmosphere showed that the solution decolorized within minutes from orange via yellow to almost colorless (an observation that was also made with Me-DuPHOS as ligand and during hydrogenations). Due to the fast transformation, the only state that could be investigated was the one in which the decolorization was already completed.…”

“…[2] However, in contrast to a- [3] and ß-dehydroamino acid derivatives, [4] only a few mechanistic investigations exist. [5] In 1978, the formation of substrate complexes from itaconic acid and the cationic Rh(I) solvate complexes with BPPM {N-(tert-butoxycarbonyl)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidi-A C H T U N G T R E N N U N G ne} and PPPM {N-pivaloyl-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine)} as ligand was firstly investigated by Ojima using NMR spectroscopy.…”

Patients’ preference for triptans and other medications as a tool for assessing the efficacy of acute treatments for migraine

“…Patients' most commonly given reasons for preferring triptans were effective relief, speed of relief, restored ability to function and fewer side effects [16,18,19,22]. These are significant results, as some controlled clinical trials have shown that sumatriptan was not superior to rapid-release tolfenamic acid [43], paracetamol/domperidone [44], aspirin/metoclopramide [45,46], isometheptene/paracetamol/dichlorphenazone [47] and paracetamol/aspirin/caffeine [48]. In contrast, a controlled clinical trial showed that oral sumatriptan 100 mg was significantly superior to oral ergotamine plus caffeine [49].…”

Aspirin and tension-type headache

“…In the early treatment of migraine, OTC medications are largely used as they do not require a medical prescription and are easily available. A combination of OTC medications (Aspirin 500 mg, acetaminophen 500 mg and caffeine 130 mg) has been compared to a prescription migraine product (sumatriptan 50 mg), underlining a significant efficacy of this association in early migraine abortive treatment [36]. A similar approach has not been investigated yet in TTH, but pain relief as a result of rapid intake seems a reasonable suggestion.…”