Acetaminophen-induced alterations in pancreatic β cells and serum insulin concentrations in B6C3F1 mice

Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis

“…Indeed, APAP could affect hepatic glucose production, as in mice, administration of a single dose of APAP increases blood glucose levels due to increased glycogenolysis [56]. In addition to the effect of APAP on hepatic glycogen depletion to increase glycemia, in vivo APAP administration alters pancreatic cells structure and damages β-cells [57], potentially further damaging pancreatic cells in the STZ model. While a direct toxic effect of APAP on the sensitized hepatic inflammatory cells cannot be ruled out, the role of APAP on glycemia and the subsequent exacerbation of a hepatic pro-inflammatory phenotype remain to be considered.…”

https://staging.acutemedjournal.co.uk/providing-better-care-for-patients-with-complex-needs-in-acute-medicine/

“…5 There are also animal studies that demonstrate changes in pancreatic beta cell ultrastructure that would account for glycaemic disturbances. 6 In addition, there are descriptions of metabolic acidosis and coma following paracetamol overdose, 7 that…”

Analytic Reviews : Management of Acetaminophen Toxicity in the Intensive Care Unit

“…Although case reports and limited animal data suggest that pancreatitis may result from acute acetaminophen toxicity, the incidence is rare and concurrent disease states and drug interactions may play a role in reported cases [48][49][50][51][52]. Treatment of acetaminophen-induced pancreatitis should focus on supportive care and NAC therapy for associated hepatic injury.…”