Acetaminophen-Induced Hepatorenal Toxicity in High Fructose Diet-Fed Rats Is Sex-Dependent.

Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice

“…Bohdanecká et al (1999) reported that rats with hereditary hypertriglyceridemia showed greater sensitibity to the nephrotoxic effect of cyclosporine A than control rats, and Yang et al (2004) reported that hypertriglyceridemia aggravated contrast media-induced nephrotoxicity through reduced production of nitric oxide. Ishida et al (1998) reported that enhancement of APAP-induced nephrotoxicity by fructose pretreatment is sex-dependent. Namely, fructose pretreatment markedly potentiates APAP-induced nephrotoxicity in male rats while it has minimal effect in female rats.…”