Acetaminophen Predisposes to Renal and Hepatic Injury from Compound A in the Fasting Rat

Laster, Michael J.; Gong, Diane; Kerschmann, Russell; Eger, Edmond I.; MARTIN, JACKIE

doi:10.1097/00132586-199710000-00020

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2005

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“…Sevoflurane undergoes dose-dependent, limited hepatic biotransformation, principally by cytochrome P450 2E1, as evidenced by increases in organic and inorganic fluoride levels (18,19). Some drugs, such as acetaminophen, used for anesthesia and/or analgesia, may participate in hepatic failure following anesthesia with sevoflurane (20,21). Thiopental may induce cytochrome P450, which in a glutathionedepleted patient leads to a increased acetaminophen metabolite, which is hepatotoxic (22).…”

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confidence: 99%

Severe hepatotoxicity after sevoflurane anesthesia in a child with mild renal dysfunction

Jang

Kim

2005

Pediatric Anesthesia

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Sevoflurane, an anesthetic agent with methyl isopropyl fluorinated ether structure, has a very low potential for hepatotoxicity. Nevertheless, a few cases of hepatotoxicity have been reported since its introduction into clinical practice. The underlying pathophysiology may be multifactorial and sometimes nonspecific. We report a case of severe hepatotoxicity after anesthesia with sevoflurane in a child with preexisting mild renal dysfunction.

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