Acetaminophen use during pregnancy: effects on risk for congenital abnormalities

Rebordosa, Cristina; Kogevinas, Manolis; Horváth‐Puhó, Erzsébet; Nørgård, Bente Mertz; Morales, María Pérez; Czeizel, Andr̀ew E.; Vilstrup, Hendrik; Sørensen, Henrik Toft; Olsen, Jørn

doi:10.1016/j.ajog.2007.08.040

Cited by 86 publications

(53 citation statements)

References 19 publications

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“…As compared with other analgesics, opioids, and nonsteroidal anti-inflammatory drugs, it has a favorable safety profile [8,9]. Recently, it has been reported not to be associated with an increased risk of congenital anomalies [10].…”

Section: Introductionmentioning

confidence: 99%

Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor

Elbohoty

Abd-Elrazek²,

Abd-El-Gawad³

et al. 2012

Intl J Gynecology & Obste

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Section: Introductionmentioning

confidence: 99%

Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor

Elbohoty

Abd-Elrazek²,

Abd-El-Gawad³

et al. 2012

Intl J Gynecology & Obste

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“…In a study from the Danish National Birth Cohort with 88 142 pregnant women and their liveborn singletons with questionnaire information about NA4AP use during the first trimester, no association of NA4AP with an increased prevalence of congenital abnormalities was found (Rebordosa et al 2008).…”

Section: Associations Between Acetaminophen Intake During Pregnancy Amentioning

confidence: 99%

“…Large studies (Werler et al 2005, Rebordosa et al 2008 have indicated NA4AP and NA4AP-containing pharmaceuticals as the most commonly used products.…”

Section: Na4ap In Human Nsaidsmentioning

confidence: 99%

Ubiquitous presence of paracetamol in human urine: sources and implications

Modick¹,

Weiß²,

Dierkes³

et al. 2014

Reproduction

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N-acetyl-4-aminophenol (acetaminophen/paracetamol, NA4AP) is one of the most commonly used over-the-counter analgesic and antipyretic drugs. Recent studies have reported anti-androgenic effects of NA4AP in vitro and possible associations between intrauterine exposure to NA4AP and the development of male reproductive disorders in humans. NA4AP is also a major metabolite of aniline (phenylamine), representing 75-86% of the aniline dose excreted in urine. Aniline is an important large-volume intermediate in several industrial processes. Besides individuals in various occupational settings with aniline exposure, the general population is also known to be ubiquitously exposed to aniline. In this article, we provide an overview of the recent literature concerning the intake of NA4AP during pregnancy and the possible anti-androgenic effects of NA4AP as well as literature concerning its known metabolic precursor aniline. We also present new research data, including the first human biomonitoring data on NA4AP excretion in urine, showing ubiquitous NA4AP body burdens in the general population at a wide range of concentrations. We found a small but significant impact of smoking on urinary NA4AP concentrations. We further present preliminary data on NA4AP excretion after therapeutic acetaminophen use, after aniline exposure in an occupational setting, and during a controlled fasting study (excluding oral exposure to both aniline and acetaminophen). Our findings indicate exposure to aniline (or aniline-releasing substances) as well as nutrition (next to the direct use of acetaminophen as medication) as possible sources of internal body burdens of NA4AP.Reproduction (2014) 147 R105-R117

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“…Although the drug can easily cross the placenta and potentially affect fetal development, most of the clinical data does not confirm the relationship between exposure to paracetamol in the early stage of pregnancy and the occurrence of an increased risk of birth defects (Rebordosa et al, 2008 a,b;Scialli et al, 2010 a,b). Nevertheless some investigators have assumed that prenatal and early lifethreatening intake of paracetamol may induce abnormalities in the immune system, with symptoms such as wheezing and asthma (Amberbir et al, 2014;Beasley et al, 2008;Becker and Schultz, 2010;Henderson and Shaheen, 2013;Tiegs et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata

Blecharz-Klin¹,

Joniec-Maciejak²,

Jawna³

et al. 2015

Environmental Toxicology and Pharmacology

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Acetaminophen use during pregnancy: effects on risk for congenital abnormalities

Cited by 86 publications

References 19 publications

Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor

Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor

Ubiquitous presence of paracetamol in human urine: sources and implications

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata

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