Acetic acid used for the elimination of<i>Pseudomonas aeruginosa</i>from burn and soft tissue wounds

Sloss, J M; Cumberland, N. S.; Milner, Stephen M.

doi:10.1136/jramc-139-02-04

Cited by 81 publications

(78 citation statements)

References 11 publications

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“…In a study conducted by Sloss et al all strains of P. aeruginosa exhibited a minimum inhibitory concentration of 2% acetic acid and application of 2% acetic acid to wounds resulted in elimination of P. aeruginosa from the wounds of 14 of the 16 patients within two weeks of treatment. 5 Al-Ibran and Khan found that application of 1% acetic acid to burns wounds cleared P. aeruginosa in 19% cases. 6 However, Juma et al reported to 2% acetic acid effective against P. aeruginosa in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Susceptibility to acetic acid and citric acid and their use in the treatment of superficial nosocomial infections caused by P. aeruginosa has been previously reported. [5][6][7][8][9][10] The topical use of various acids for elimination of P. aeruginosa from skin and soft tissue infections and from burn infections has been reported by various workers. [5][6][7][8] The use of acetic acid has been reported from time to time as a topical agent for the treatment of pseudomonal infections of burns and skin and soft tissue infections.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10] The topical use of various acids for elimination of P. aeruginosa from skin and soft tissue infections and from burn infections has been reported by various workers. [5][6][7][8] The use of acetic acid has been reported from time to time as a topical agent for the treatment of pseudomonal infections of burns and skin and soft tissue infections. In a study conducted by Sloss et al all strains of P. aeruginosa exhibited a minimum inhibitory concentration of 2% acetic acid and application of 2% acetic acid to wounds resulted in elimination of P. aeruginosa from the wounds of 14 of the 16 patients within two weeks of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4] The use of various organic acids notably acetic acid and citric acid for elimination of P. aeruginosa from skin and soft tissue infections and from burn infections has been reported by various workers. [5][6][7][8][9][10] In the present study we aimed to investigate in vitro sensitivity of P. aeruginosa to various organic acids such as oxalic acid, lactic acid and trichloroacetic acid in addition to acetic acid and citric acid.…”

Section: Introductionmentioning

confidence: 99%

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In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids

Nagoba¹,

Wadher²,

Selkar³

2013

Jmid

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Objectives: Pseudomonas aeruginosa is a classic opportunistic pathogen with innate resistance to many antibiotics and disinfectants. Resistance to antimicrobial agents makes it the most noxious organism to eliminate from infection site. In view of its antimicrobial resistance, an attempt was made to study its susceptibility to various organic acids. Methods:Seven clinical isolates of P. aeruginosa resistant to multiple antibiotics were subjected to in vitro susceptibility to various organic acids by broth dilution method to find out susceptibility to various organic acids. Results:The isolates of P. aeruginosa resistant to 14 antimicrobials were found susceptible to one percent oxalic acid and trichloroacetic acid, two percent lactic acid and citric acid, and three percent acetic acid. It is interesting to note that strains resistant to multiple antibiotics were also found susceptible to organic acids. Oxalic acid and trichloroacetic acid were found highly effective. Conclusions:Clinical use of oxalic acid, trichloroacetic acid and lactic acid as topical agents to treat superficial pseudomonal infections caused by difficult strains of P. aeruginosa may be recommended after confirmation of their toxicity and in vivo efficacy in animal models. J Microbiol Infect Dis 2013; 3(2): 67-70

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids

Nagoba¹,

Wadher²,

Selkar³

2013

Jmid

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“…No delay of reepithelization has been found in animal and human models [8]. In two human uncontrolled studies, acetic acid was found to be beneficial in wounds infected with pseudomonas [9,10].…”

Section: Acetic Acidmentioning

confidence: 99%

Topical Antimicrobials in Wounds

Jain¹,

Varma²

2013

Med-Science

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Wounds are a major cause of morbidity especially diabetic foot wounds. Topical antimicrobials are frequently used in day to day practice mainly in management of wounds by various healthcare professionals ranging from general practitioner to specialist surgeons. However lot of controversies exists regarding the usage of antimicrobials. This article provides an insight on the usage of various commonly used topical antimicrobials including their mechanism of action and various side effects.

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Biopolymer Nano‐Network for Antimicrobial Peptide Protection and Local Delivery

Klubthawee

Bovone

Marco‐Dufort

et al. 2022

Adv Healthcare Materials

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Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemical modification. Mixing and concentration of oppositely charged particles form a nano-network with the rheological properties of a cream or injectable hydrogel. After exposure to proteolytic enzymes, the formed nano-network loaded with PA-13 eliminates Pseudomonas aeruginosa during in vitro culture and in an ex vivo porcine skin model while the unencapsulated PA-13 shows no antibacterial effect. This demonstrates the ability of the nano-network to protect the antimicrobial peptide in an enzyme-challenged environment, such as a wound bed. Overall, the nano-network presents a useful platform for antimicrobial peptide protection and delivery without impacting peptide bioactivity.

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Acetic acid used for the elimination ofPseudomonas aeruginosafrom burn and soft tissue wounds

Cited by 81 publications

References 11 publications

In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids

In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids

Topical Antimicrobials in Wounds

Biopolymer Nano‐Network for Antimicrobial Peptide Protection and Local Delivery

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