Acetonitrile as a Constituent of Cigarette Smoke

Campbell, John K.; Rhoades, John W.; Gross, Arthur

doi:10.1038/198991b0

Cited by 20 publications

(11 citation statements)

References 2 publications

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“…Acetonitrile revealed a 3.5 to 5 times higher level in the smoker’s sample (P3). This result is in accordance with earlier studies, reporting higher levels of this component of tobacco smoke [44] in smokers’ exhaled breath [8,18]. Ethanol is present only in samples P1 and P3 with a 17 times higher level in the latter.…”

Section: Resultssupporting

confidence: 93%

Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy

Rothbart

Holz

Koczulla

et al. 2019

Sensors

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Breath gas analysis is a promising tool for medical research and diagnosis. A particularly powerful technological approach is millimeter-wave/terahertz (mmW/THz) spectroscopy, because it is a very sensitive and highly selective technique. In addition, it offers the potential for compact and affordable sensing systems for wide use. In this work, we demonstrate the capability of a mmW/THz spectrometer for breath analysis. Samples from three volunteers and a sample from ambient air were analyzed with respect to 31 different molecular species. High-resolution absorption spectra were measured by scanning two absorption lines from each species. Out of the 31, a total of 21 species were detected. The results demonstrate the potential of mmW/THz spectroscopy for breath analysis.

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Section: Resultssupporting

confidence: 93%

Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy

Rothbart

Holz

Koczulla

et al. 2019

Sensors

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“…Tobacco smoking changes the composition of exhaled air, i.e. the levels of some exhaled volatiles increase either because they are ingested from tobacco smoke or because they are produced in the body as a response to the irritant effects of smoking [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Compounds enhanced in a mass spectrometric profile of smokers' exhaled breath versus non-smokers as determined in a pilot study using PTR-MS

et al. 2008

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A pilot study has been carried out to define typical characteristics of the trace gas compounds in exhaled breath of non-smokers and smokers to assist interpretation of breath analysis data from patients who smoke with respiratory diseases and lung cancer. Exhaled breath was analyzed using proton transfer reaction-mass spectrometry (PTR-MS) for 370 volunteers (81 smokers, 210 non-smokers, 79 ex-smokers). Volatile organic compounds corresponding to product ions at seven mass-to-charge ratios (m/z 28, 42, 69, 79, 93, 97, 123) in the PTR-MS spectra differentiated between smokers and non-smokers. The Youden index (= maximum of sensitivity + specificity - 1, YI) as a measure for differentiation between smokers and non-smokers was YI = 0.43 for ions at the m/z values 28 (tentatively identified as HCN), YI = 0.75 for m/z = 42 (tentatively identified as acetonitrile) and YI = 0.53 for m/z = 79 (tentatively identified as benzene). No statistically significant difference between smokers and non-smokers was observed for the product ions at m/z = 31 and 33 (compounds tentatively identified as formaldehyde and methanol). When interpreting the exhaled breath of lung cancer or COPD patients, who often smoke, compounds appearing at the above-mentioned seven mass-to-charge ratios should be considered with appropriate care to avoid misdiagnosis. Validation studies in larger numbers of patients with more precise delineation of their smoking behavior and using additional analytical techniques such as GC/MS and SIFT-MS should be carried out.

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“…10 The absence of thiocyanate in sputlIDl confirms that the metabolic conversion of cyanide to thiocyanate is brought about by the enzymes present in the saliva of the mouth.…”

Section: Specimenmentioning

confidence: 61%