Acetophenetidin Nephritis and Papillary Necrosis

Rubenstein, A. H.; Abrahams, Cyril; Stables, Derek P.; Levin, Nathan W.

doi:10.1001/archinte.1964.00280090064011

Cited by 26 publications

(5 citation statements)

References 26 publications

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“…At the 6-month followup, renal function of the donor and recipient were normal, but pigmentation in this case was lipofuscin; 4 lipofuscin pigmentation has been called the aging pigment or phenacetin analgesic nephropathy. 26,27 In 1964, Biava and colleagues reported on 114 patients with lipofuscin-like granules in renal vascular smooth muscle cells. Patient age ranged from 2 to 70 years.…”

Section: Discussionmentioning

confidence: 99%

Normal black kidney

Yarmohamadi

Rezayat

Memar

et al. 2014

CUAJ

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A black kidney has 3 major differential diagnoses: hemosiderosis, lipofuscin pigment and melanotic renal cell carcinoma. Excluding lipofuscin, the other 2 are accompanied by an abnormal renal function. We report on a 25-year-old man who intended to donate a kidney to his cousin. On the operating room table when we incised the left flank region and exposed the kidney, we found a firm and black kidney so the operation was cancelled due to potential vascular injuries. Days after the incomplete procedure, we reviewed the donor's biochemistry and imaging to reassess his renal function, but the results showed quite normal renal function again. The result of Ham test was also negative. Two weeks later, we began the operation, removed the same left kidney and found that it was in the same conditions as it was before. We took the opportunity to send needle biopsies of the kidney for histopathologic analysis. The analysis showed a melanotic kidney without pathological changes in glomeruli and interstitium and vessels. A black kidney may result in hemosiderin, lipofuscin or melanin deposits in the kidney, which can confirm the diagnosis; however, special tests for underlying disease and renal function should be considered. Some causes of black kidney lead to abnormal function, but our patients's kidney returned to normal.

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Section: Discussionmentioning

confidence: 99%

Normal black kidney

Yarmohamadi

Rezayat

Memar

et al. 2014

CUAJ

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“…The severe cortical damage is not against the diagnosis especially as it is out of proportion to the vascular damage. The hepatic lipofuscin deposition is further evidence of a tissue response to phenacetin Rubinstein et al, 1964). Renal lesions have been described in ulcerative colitis by Jensen, Baggenstoss & Bargen (1950), but none of their cases developed papillary necrosis or chronic pyelonephritis.…”

Section: Discusionmentioning

confidence: 95%

Phenacetin nephropathy in a patient with an ileostomy

Dyer

Lee

1967

Postgraduate Medical Journal

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“…Recent reviews of the subject have been published (435,1079,1383). Although phenacetin has been incriminated in most reports, with rare exceptions the analgesics ingested have been mixtures of drugs-varyingly salicylate, caffeine, antipyrine, aminopyrine and codeine.…”

Section: The Problem Of Analgesics and Nephritismentioning

confidence: 99%

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

1966

Arthritis & Rheumatism

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Acetophenetidin Nephritis and Papillary Necrosis

Cited by 26 publications

References 26 publications

Normal black kidney

Normal black kidney

Phenacetin nephropathy in a patient with an ileostomy

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

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