2000
DOI: 10.1007/bf02680012
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Acetyl-CoA metabolism in cholinergic neurons and their susceptibility to neurotoxic inputs

Abstract: Cholinergic neurons, unlike other brain cells utilize acetyl-CoA not only for energy production but also for acetylcholine (ACh) synthesis. Therefore, suppression of acetyl-CoA metabolism by different neurotoxic inputs may be particularly harmful for this group of cells. Differentiation of SN56 cholinergic hybrid cells increased their choline acetyltransferase (ChAT) activity and ACh content but depressed pyruvate dehydrogenase activity and acetyl-CoA content. Differentiated cells were more susceptible to acut… Show more

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Cited by 29 publications
(46 citation statements)
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“…2, Table II). These findings correspond well with NOevoked growth inhibition and induction proapoptotic state in DC SN56 cells and absence of such effects in NC ones (Table II) Szutowicz et al, 2000). Additive effects of NO and Al on Ca accumulation were also more evident in DC than in NC SN56 .…”
Section: Effects Of Nosupporting
confidence: 77%
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“…2, Table II). These findings correspond well with NOevoked growth inhibition and induction proapoptotic state in DC SN56 cells and absence of such effects in NC ones (Table II) Szutowicz et al, 2000). Additive effects of NO and Al on Ca accumulation were also more evident in DC than in NC SN56 .…”
Section: Effects Of Nosupporting
confidence: 77%
“…It is also unclear why considerable loss of cholinergic neurons takes place in AD and other encephalopathies (Szutowicz et al, 1996;Pappas et al, 2000). Our studies indicate that neurotoxic factors involved in pathogenesis of neurodegeneration, such as Al, NO, ␤-A, as well as NGF, are implicated in impairment of acetyl-CoA and energy metabolism in neuronal cells (Bielarczyk et al, 1998;Tomaszewicz et al, 1998;Szutowicz et al, 2000).…”
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confidence: 61%
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