Acetylacetone-formaldehyde reagent for the spectrophotometric determination of some sulfa drugs in pure and dosage forms

Spectrophotometric and Spectrofluorimetric Methods for the Determination of Tranexamic Acid in Pharmaceutical Formulation

“…16) In the same manner, acetylacetone together with formaldehyde react with aliphatic amines by Hantzsch reaction forming a yellow product that can be measured spectrophotometrically or spectrofluorimetrically. The reaction was applied for the determination of certainsulpha-drug 17) mesalamine 18) different b-lactam antibiotics, [19][20][21][22] aminoglycosides, 23,24) lisinopril 25) and more recently gaba- Two simple and sensitive spectrophotometric and fluorimetric methods for the determination of tranexamic acid in tablets are developed. The methods are based on condensation the primary amino group of tranexamic acid with acetyl acetone and formaldehyde producing a yellow coloured product, which is measured spectrophotometrically at 335 nm or fluorimetrically at 480 nm the colour was stable for at least 1 h. Beer's law was valid within a concentration rang of 0.05-2.0 m mg ml ؊1 spectrophotometrically and 0.05-0.25 m mg ml ؊1 fluorimetrically.…”

A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

“…Standard solution of sulfonamide (1000 mg mL -1 ) was prepared by dissolving 100 mg each sulfonamide in 2.0 mL of sulfuric acid (10 mol L -1 ), then diluting with water to mark in a 100-mL volumetric flask. A working standard solution of each sulfonamide containing 25 mg mL -1 was prepared by further dilution and was standardized by the British Pharmacopoeia method (4) and the reported method (21). An 8-HQ solution (0.5%, m/V), sodium nitrite (1.0%, m/V) sulphamic acid (2%, m/V), sodium hydroxide (5 mol L -1 ) and sulphuric acid (10 mol L -1 ) were prepared in water.…”

Spectrophotometric Determination of Sulfacetamide and Sulfamethaxazole in Aqueous Solution Using Tetracyanoethylene Reagent

“…These include gravimetric [4][5], titrimetric [6], potentiometric [7], amperometric [8] polarographic [9], chromatographic [10][11], flame spectroscopic [12], and fluorimetric [13], methods. Several spectrophotometric methods using various reagents such as 2,3-dichloro-5,6-dicyano-1,4-benzoquinone [14], 7,7,8,8 tetracyano quinodimethane [15], chloranil [16], 8-hydroxyquinoline [17], acetyl acetone-formaldehyde [18], furfuraldehyde [19], and N-(1-naphthyl) ethylene diamine [20], have been reported for determination of sulphonamide derivatives.…”