Acetylation of Alcohols, Amines, Phenols, Thiols under Catalyst and Solvent-Free Conditions

Abstract

In the present study, an easy and an efficient approach is reported for the acetylation of alcohols, amines, phenols, and thiols under solvent- and catalyst-free conditions. The experimental conditions were milder than conventional methods and the reactions were completed in shorter reaction time. The examined substrates afforded higher yields of the acetylated products under the short reaction time. Comparison of this work with earlier reported procedures reveals that this method offers some advantages than with reported catalysts and solvents. The as-synthesized products were characterized by 1H-NMR and GC-MS techniques to ensure their purity and identity. In addition, a possible mechanism was also proposed for this reaction.

Magnetically recyclable silica-coated ferrite magnetite-K10 montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions

“…[22][23][24][25][26][27][28][29][30] Recently, Anbu et al have reported the solvent and catalyst free process for the acylation reaction. 31 But, all these reported processes are associated with a number of limitations such as longer reaction time, use of toxic solvents, high reaction temperature and ease of handling. Therefore, there is still a need for the development of new catalysts that can be used under mild reaction conditions to get the good yield of the acetylated products using green chemistry.…”

Oxy-Polybrominated Diphenyl Ethers from the Indonesian Marine Sponge, Lamellodysidea herbacea: X-ray, SAR, and Computational Studies

“…To date, acetylation with acyl halides or acid anhydrides has been reported using solvents and catalysts at room temperature or higher (>40 • C). Acetylation methods have been reported without catalysts at high solvent temperatures (60-70 • C) or with a variety of catalysts from room temperature to 110 • C [22]. With regard to PBDE molecules, only 11 has been obtained from acetylation using Ac 2 O with pyridine at room temperature for 24 h [23].…”

One-bath One-step Dyeing of Polyester/Cotton (PC) Blends Fabric With Disperse Dyes After Acetylation of Cotton

“…The reaction conditions depend on several factors including time of reaction and concentration of acetic anhydride that keeps varying to determine the optimum conditions for the acetylation. The concentration of acetic anhydride used for acetylation were 10 to 20% and 6gpl of zinc chloride as a catalyst at MLR of 1:10 and the time of reaction was 1-4hr at room temperature due to temperature effects tensile strength of the fabric [16,17]. The combination of glacial acetic acid at 1:2 ratios to sample weight used for acetylation method.…”