Acetylcholinesterase Inhibitors Test Confirmed Myasthenia Gravis in Psychosis Remitted by Aripiprazole

Through this research, our main focus was: to investigate the biochemical brain metabolites (NAA-N-acetylaspartate, GABA-Gama-Aminobutyric Acid, Asp-Aspartate, CR-Creatine, Gln-Glutamine, GPC-Glicerophosphocholine, PC-Phosphocholine, PCr-Phosphocreatine, Tau-Taurine, N-MDA-N-Metyl-D-Aspartate, Serine, Glicine, Cho-Choline); the neuroimagistic, the brain biochemical and metabolic abnormalities in children and adolescents with epilepsy before and after treatment; to review the main antiepileptic medication administered to these patients; and to make some correlations with the results obtained through Magnetic Resonance (MR) Spectroscopy, for further proper early detection and intervention in children and adolescents with epilepsy. Our research was performed between 2010-2017, involving 45 children and adolescents with epilepsy. Also, the patients were evaluated through MR Spectroscopy at baseline and after pharmacotherapy. Through the MR Spectroscopy, we investigated key aspects of the brain function and metabolism. The antiepileptic medication was chosen according to the guides and the type of epileptic seizures. The efficacy of the chosen therapy was evaluated through the change of the relevant MR spectroscopy biochemical brain metabolites. Our results, showed statistically significant modified values and concentrations of the biochemical cerebral metabolites. Our research was a proof, which the evaluation of the biochemical brain metabolites through MR Spectroscopy is of high clinical utility in prevention, early detection and intervention in epilepsy in children and adolescents.

Section: Results Of the Metabolic Abnormalities Investigationsmentioning

confidence: 99%

Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment

Nussbaum¹,

Hogea²,

Folescu³

et al. 2018

“…A small number of patients take drugs that can increase BP as non-steroidal anti-inflammatory agents, aspirin, oral contraceptives, amphetamines, gluco-and mineralocorticoids, nasal drops, liquorice, etc. [46][47][48][49][50][51]. The main characteristics of patients with RH are presented in figure 8.…”

Section: Resultsmentioning

confidence: 99%

Prevalence, Biochemical and Clinical Characteristics of Resistant Hypertension

Gurguş¹,

Ardeleanu²,

Gadau³

et al. 2018

The objectives of the present study were to evaluate the prevalence of resistant hypertension (RH) in primary care setting and to analyse its biochemical and clinical characteristics. After 3 months of treatment and evaluation, 721 (14.01%) of 5,146 patients with hypertension did not reach target office blood pressure of [ 140/90 mmHg. After exclusion of �white-coat effect� with ambulatory blood pressure, of secondary and pseudo- resistant hypertension, prevalence of RH was 6.74%. Lifestyle factors associated with RH were physical inactivity, obesity, high salt intake, smoking and excessive alcohol ingestion. Compared to controlled hypertension, RH patients presented higher incidence of family history of cardiovascular disease (38.90% vs 25.94%), diabetes mellitus (34.87% vs 19.01%), impaired fasting glucose (21.91% vs 19.07%), target organ damage (29.1% vs 15.95%), and cardiovascular disease (27.09% vs 17.06%). Dyslipidaemia (52.90% vs 42.03%), fasting plasma glucose (116.10�38.9 vs 107.80�37.2), HbA1c (6.41�1.42 vs 5.96�0.94), serum creatinine (1.09�0.27 vs 1.03�0.24) and microalbuminuria (21.90% vs 10.95%) were significantly higher in RH. Predictors of RH, determined by a multivariate logistic regression analysis were left ventricular hypertrophy (OD 2.14, 95% CI 1.32-3.69), renal impairment expressed as eGFR [ 60 ml/min/1.73m2 (OD 1.62, 95% CI 1.21-2.21) and the presence of cardiovascular disease (OD 1.48, 95% CI 1.02-2.16).

“…Consequently, the efficient management of resources represents an important objective for the beekeepers aiming to increase the economic benefits, and the energy efficiency meets the current needs of the human civilization, under the conditions of increasing in food necessary and with the hope to increase the humans' wellbeing [21][22][23][24][25].…”

Section: Resultsmentioning

confidence: 99%

Monitoring the Anthropogenic Toxicity of Spontaneous Flora in Neamt County through Studies of the Honey Bee Chemical Characteristics

Bodescu¹,

Ungureanu²,

Moraru³

et al. 2018

The products of honey bees can be used as indicators and monitors of a variety of environmental pollutants because of the bees� ability to collect materials that reflect their immediate environmental conditions. Human activities produce more waste and administrate the pesticides, the amounts and toxicity of which often exceed the environment�s homeostatic capacity to cleanse itself, and this is constantly transforming due to intensive agricultural practices necessary to increase food production as human population grows. The main sources for contamination of honey with heavy metals are represented by placing hives near urban areas with heavy car traffic, or industrialized areas and the use on the entire circuit of production, objects or containers made of materials unsuitable (unacceptable). For that reason regular monitoring of the environment is so important. Honey bees, thanks to their morphological features, and also bee products are regarded as good indicators of environmental pollution by toxic substances, be these heavy metals, radioactive elements or persistent organic pollutants such as pesticides. Consequently, it is important to estimate the environmental fate and Eco toxicological effects of these different xenobiotic. Honey bees (Apis mellifera L.) have been used as biological indicators of Plant Protection Products (PPPs) in two intensely cultivated in areas of Neamt County, Romania. This area is representative for the pre-mountain and mountain zone of Romania. The stratified sample has been face-to-face interviewed in 2016 regarding the data from the year 2015. The total consumption specific for the honey production was about 628 MJ hive-1, and the energy output reached 235 MJ hive-1, determining an energy productivity of 0.030 kg MJ-1 and an energy use efficiency of 0.37. Specific energy amounted 33.3MJ kg-1 due to the inefficiency of traveling during the apiaries movements and the inappropriate correlation between the apiaries size and the zonal melliferous potential. In this paper available literature data and information on the morphological features of the honey bee, the utilization of the honey bee and its products as indicators of environmental pollution, and a historical outline of some of the legislation relating to beekeeping have been critically compared and discussed.