Acetylsalicylic acid and ascorbic acid combination improves cognition; Via antioxidant effect or increased expression of NMDARs and nAChRs?

Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats

“…*P # .05. memory of ischemic animals higher than ASA/hUCMadministrated animals. Our findings on valuable effect of ASA administration in spatial learning and memory improvement after brain ischemia are comparable with those reported by Wang et al 19 and Kara et al 20 ASA has been shown to improve cognitive state and antioxidative status in serum. 21 Despite numerous reports on the positive effects of ASA in brain stroke, it is still unclear how ASA might influence cognitive function and needs more investigations.…”

Exploring the effect of vitamin C on sleep deprivation induced memory impairment

“…In support, current results show that major molecules/enzymes involved in antioxidant defense such as GSH/GSSG ratio, catalase, and SOD are prevented by VitC treatment during sleep deprivation. In accordance with that, a previous study reported reduced hippocampal oxidative stress, as indicated by reduced 8-hydroxy-2-deoxyguanosine and malondialdehyde levels as results of 10 weeks VitC treatment (Kara et al, 2014). In fact, VitC does not act alone in the brain.…”

Chemical composition, antioxidant potential, macromolecule damage and neuroprotective activity of Convolvulus pluricaulis

“… 56 showed that Vitamin E protects nerve cells from amyloid β protein induced toxicity. Ascorbic acid has been reported for its diverse neuroprotective activities, such as improvement of cognition 57 ; to treat epilepsy, 58 and also inhibits seizures. 59 Thus it can be postulated that the identified bioactive compounds of C. pluricaulis may account for the observed antioxidant and neuroprotective effects against H 2 O 2 induced oxidative stress in SH-SY5Y cells.…”