Acetylsalicylic Acid, at High Concentrations, Inhibits Vascular Smooth Muscle Cell Proliferation

Bernhardt, J.; Rogalla, K; Lüscher, Thomas F.; Bühler, Fritz R.; Resink, Thérèse J.

doi:10.1097/00005344-199306000-00019

Cited by 17 publications

(7 citation statements)

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“…To our knowledge, this is the first time that the effect of aspirin on MSC has been investigated. The present results are consistent with those of other studies demonstrating that aspirin is able to inhibit the proliferation of a variety of cell types 12,13,17 and the concentrations of aspirin used in the present study were consistent with those used previously as well. Both aspirin and MSC are important medications for cardiovascular disease, but our experiments indicate that aspirin may be disadvantageous at the initial stage of MSC transplantation because of the well‐known fact that proliferation is an essential process in MSC therapy.…”

Section: Discussionsupporting

confidence: 93%

“…However, in recent years, growth inhibition by aspirin has come to the fore. Many studies have indicated that aspirin is able to inhibit the growth of various cell types, including endothelial cells, vascular smooth muscle cells and, in particular, cancer cells 12–19 . However, what effect aspirin may have on the growth regulation of MSC is unkown.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have indicated that aspirin is able to inhibit the growth of various cell types, including endothelial cells, vascular smooth muscle cells and, in particular, cancer cells. [12][13][14][15][16][17][18][19] However, what effect aspirin may have on the growth regulation of MSC is unkown. In patients who are candidates for MSC transplant, there is usually a history of taking aspirin or the need for the further use of aspirin.…”

Section: Introductionmentioning

confidence: 99%

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GROWTH INHIBITION OF MESENCHYMAL STEM CELLS BY ASPIRIN: INVOLVEMENT OF THE WNT/β‐CATENIN SIGNAL PATHWAY

Wang

Chen

Zhu

et al. 2006

Clin Exp Pharma Physio

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1. Mesenchymal stem cell (MSC) therapy is drawing increasing attention in cardiology. However, the effect of aspirin, an assistant medication used extensively in the treatment of cardiovascular diseases, on MSC is not clear. 2. In the present study, we investigated the effect of aspirin on the growth of MSC in vitro and the underlying mechanism of its action. 3. The 3-(4,5-dimethyl-2 thiazoyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay revealed that 1, 5 and 10 mmol/L aspirin inhibited the growth of MSC by 18, 37 and 62%, respectively. DNA synthesis of MSC was inhibited by 25, 57 and 90% following treatment with 1, 5 and 10 mmol/L aspirin, respectively, as determined by the tritiated thymidine incorporation assay. No cytotoxicity was observed based on Trypan blue dye exclusion and cell morphological observations. Western blot analysis demonstrated that the protein level of phosphorylated beta-catenin increased, whereas that of cyclin D1 decreased, after treatment of MSC with aspirin. Cell cycle analysis showed that aspirin failed to significantly alter the proportion of cells in different stages of the cell cycle. 4. These observations indicate that aspirin inhibits MSC proliferation and that the downregulation of the wnt/beta-catenin signal pathway may be involved in the growth inhibition of MSC by aspirin.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

GROWTH INHIBITION OF MESENCHYMAL STEM CELLS BY ASPIRIN: INVOLVEMENT OF THE WNT/β‐CATENIN SIGNAL PATHWAY

Wang

Chen

Zhu

et al. 2006

Clin Exp Pharma Physio

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“…Aspirin has a range of beneficial effects on large vessels, including inhibiting vasoconstriction [17], inhibiting smooth muscle proliferation [18], suppressing vascular inflammation [19] and improving endothelial dysfunction [20]. However, it is not known if such effects also occur in the small blood vessels.…”

Section: Discussionmentioning

confidence: 99%

“…The reduction in the incidence of cardiovascular events achieved by aspirin use [14] has traditionally been attributed to its antiplatelet effects in inhibiting thromboembolism in large arteries [15]. However, there is evidence that aspirin also has direct, non-platelet-mediated effects on large artery walls [16][17][18][19][20][21], which may contribute to the reduction in cardiovascular events. Whether aspirin has similar effects on the small vessels of the microcirculation remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study

Liew

Mitchell

Leeder

et al. 2006

Journal of Hypertension

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Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects

Mehta

1998

Clinical Cardiology

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Summary:Aspirin is widely used in the treatment and prevention of coronary artery disease (CAD). However, other platelet inhibitory agents, which inhibit platelet activation, have not been found to be effective or as effective as aspirin. The discrepancy between the efficacy of these compounds and aspirin suggests that the therapeutic efficacy of aspirin may not be limited to its platelet inhibitory effect. In this review, the basis for a unique place for aspirin in the therapy of patients with CAD is discussed. The author believes that the nonplatelet-mediated effects of aspirin could be more important than the platelet inhibitory effect, or at least may complement the platelet inhibitory effects of aspirin in patients with acute myocardial ischemia and in others undergoing intracoronary procedures.

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Acetylsalicylic Acid, at High Concentrations, Inhibits Vascular Smooth Muscle Cell Proliferation

Cited by 17 publications

References 0 publications

GROWTH INHIBITION OF MESENCHYMAL STEM CELLS BY ASPIRIN: INVOLVEMENT OF THE WNT/β‐CATENIN SIGNAL PATHWAY

GROWTH INHIBITION OF MESENCHYMAL STEM CELLS BY ASPIRIN: INVOLVEMENT OF THE WNT/β‐CATENIN SIGNAL PATHWAY

Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study

Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects

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