Acetylsalicylic acid, bleeding time and age

Jørgensen, Kaj Anker; Dyerberg, Jørn; Olesen, Anne Vingaard; Stoffersen, Erik

doi:10.1016/0049-3848(80)90007-9

Cited by 67 publications

(24 citation statements)

References 21 publications

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“…In both cases age was the second determinant of bleeding time and that relation was independent of the more important determinant, platelet mass. The variation of bleeding time with age was similar to that described by Jorgensen et al 19 The shortened bleeding time in myocardial infarction could either be related to the cause or be an effect of myocardial infarction; however, there are several arguments that the shortened bleeding time may have predated the myocardial infarction. Firstly, O'Brien et al have shown that the bleeding time is shorter between three months and five years after myocardial infarction,8 pointing to a chronic change.…”

Section: Discussionsupporting

confidence: 84%

Shortened bleeding time in acute myocardial infarction and its relation to platelet mass.

Milner¹,

Martin²

1985

BMJ

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Section: Discussionsupporting

confidence: 84%

Shortened bleeding time in acute myocardial infarction and its relation to platelet mass.

Milner¹,

Martin²

1985

BMJ

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“…J0rgensen et al 20 showed that a dose as low as l mg/kg body weight increased the bleeding time significantly, yet the authors favoured a dose of 3.5 mg/kg.…”

Section: Resultsmentioning

confidence: 99%

Prolongation of bleeding time and inhibition of platelet aggregation by low-dose acetylsalicylic acid in patients with cerebrovascular disease.

Boysen¹,

Boss²,

Ødum³

et al. 1984

Stroke

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Platelet aggregation and bleeding time was measured in 43 cerebrovascular patients participating in a controlled double-blind study of low-dose acetylsalicylic acid. In 19 patients with satisfactory inhibition of the platelet aggregation obtained by 50 to 70 mg acetylsalicylic acid per day the bleeding time averaged 11.2 minutes in contrast to 7.0 minutes in the placebo group, p less than 0.001. This study confirms our previous findings of platelet inhibition by low-dose acetylsalicylic acid in patients with cerebrovascular disease. The prolongation of the bleeding time demonstrates that we are dealing not merely with an in vitro phenomenon but with a significant in vivo effect. The study provides the rationale for clinical evaluations of low-dose acetylsalicylic acid in stroke prophylaxis.

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“…However, the bleeding time, a test that evaluates both the number of circulating platelets as its functionality, decreases with age [26,27]. It has also been observed that with age, lower concentrations of agonists such as ADP or collagen are needed to induce platelet aggregation [28,29].…”

Section: Primary Hemostasis During Aging A) Plateletsmentioning

confidence: 97%