Shortened bleeding time in acute myocardial infarction and its relation to platelet mass.

Milner, P C; Martin, John F.

doi:10.1136/bmj.290.6484.1767

Cited by 61 publications

(44 citation statements)

References 19 publications

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“…BT has been extensively used to evaluate primary haemostasis in which platelets and vascular tone are the main factors. 26 We showed that a 1-h ALDO infusion at a dose of 30 µg/kg/h significantly reduced BT. We also observed that the ALDO infusion caused a 27% increase in platelet adhesion.…”

Section: Discussionmentioning

confidence: 93%

Study of the mechanisms of aldosterone prothrombotic effect in rats

Gromotowicz

Szemraj

Stankiewicz

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Introduction: We investigated the role of primary haemostasis, fibrinolysis, nitric oxide (NO) and oxidative stress as well as mineralocorticoid receptors (MR) in acute aldosterone prothrombotic action. Materials and methods: Venous thrombosis was induced by stasis in Wistar rats. Aldosterone (ALDO; 10, 30, 100 μg/ kg/h) was infused for 1 h. Eplerenone (EPL; 100 mg/kg, p.o.), a selective MR antagonist, was administered before ALDO infusion. Bleeding time (BT) and platelet adhesion to collagen were evaluated. The expression of nitric oxide synthase (NOS), NADPH oxidase, superoxide dismutase (SOD) and plasminogen activator inhibitor (PAI-1) was measured. NO, malonyl dialdehyde (MDA) and hydrogen peroxide (H 2 O 2 ) plasma levels were assayed. Results: Significant enhancement of venous thrombosis was observed after ALDO infusion. ALDO shortened BT and increased platelet adhesion. Marked increases were observed in PAI-1, NADPH oxidase and SOD mRNA levels. MDA and H 2 O 2 levels were augmented in ALDO-treated groups, and NOS expression and NO level were decreased. EPL reduced ALDO effects on thrombus formation, primary haemostasis, PAI-1 expression and MDA level. Conclusion: Short-term ALDO infusion enhances experimental venous thrombosis in the mechanism involving primary haemostasis, fibrinolysis, NO and oxidative stress-dependent pathways. The MR antagonist only partially diminished the ALDO effects, suggesting the involvement of additional mechanisms.

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Section: Discussionmentioning

confidence: 93%

Study of the mechanisms of aldosterone prothrombotic effect in rats

Gromotowicz

Szemraj

Stankiewicz

et al. 2011

J Renin Angiotensin Aldosterone Syst

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“…Increased platelet aggregability has been found to be associated with the pathogenesis of MI (21-23) and stroke (24). In addition, a significantly shorter bleeding time was found in patients with diagnosed MI when compared with patients without MI (25,26). Thus, tail blood bleeding time was selected as a simple readout for the cardiac risk for chronic administration of rofecoxib in the current study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events

Liu

Yang

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

123

102

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Chronic administration of high levels of selective COX-2 inhibitors (coxibs), particularly rofecoxib, valdecoxib, and parecoxib, increases risk for cardiovascular disease. Understanding the possibly multiple mechanisms underlying these adverse cardiovascular events is critical for evaluating the risks and benefits of coxibs and for development of safer coxibs. The current understanding of these mechanisms is likely incomplete. Using a metabolomics approach, we demonstrate that oral administration of rofecoxib for 3 mo results in a greater than 120-fold higher blood level of 20-hydroxyeicosatetraenoic acid (20-HETE), which correlates with a significantly shorter tail bleeding time in a murine model. We tested the hypothesis that this dramatic increase in 20-HETE is attributable to inhibition of its metabolism and that the shortened bleeding time following rofecoxib administration is attributable, in part, to this increase. The s.c. infusion of 20-HETE shortened the tail bleeding time dramatically. Neither 20-HETE biosynthesis nor cytochrome P4A-like immune reactivity was increased by rofecoxib administration, but 20-HETE production increased in vitro with the addition of coxib. 20-HETE is significantly more potent than its COX-mediated metabolites in shortening clotting time in vitro. Furthermore, 20-HETE but not rofecoxib significantly increases rat platelet aggregation in vitro in a dose-dependent manner. These data suggest 20-HETE as a marker of rofecoxib exposure and that inhibition of 20-HETE's degradation by rofecoxib is a partial explanation for its dramatic increase, the shortened bleeding time, and, possibly, the adverse cardiovascular events associated with rofecoxib. cardiovascular side effect | coxib | eicosanoids | metabolomics | Vioxx

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“…(16)(17) Short BT in male may be due to enhanced number of platelet reactivity and aggregation. (18)(19)(20)(21)(22) It was reported that platelet count were shown to decrease progressively with age, with the consequence that thrombocytopenia was more common among the elderly, while thrombocytosis was more frequent among younger people. (23) Thrombocytosis is associated with an increased risk of thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Bleeding time and Clotting Time in Healthy Male and Female College Students of Karukutty Village, Kerala

Kumar¹,

Vk²,

George³

et al. 2013

Health Prospect

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BackgroundIt was reported that females are having high Bleeding time and clotting time than males. The reason for prolonged bleeding and clotting time in females is not clear. The studies on Bleeding time and Clotting time in healthy male and female college students of Kerala are inadequate. Therefore the present study was undertaken to measure and compare bleeding time and clotting time in male and female college students. MethodologyTwo hundred and twenty two healthy male and female college students, were enrolled in the present study. Bleeding time was estimated by Duke Method and clotting time was estimated by capillary tube method. ResultsMean age of the participants of present study is 19±1. We have observed higher bleeding time (BT) and clotting time (CT) in females (155.45±34.91 seconds and 318.18±64.40 seconds) than males (96.06±55.05 seconds and 223.01±50.74 seconds) which is statistically significant (p value <0.001). Minimum and Maximum bleeding time observed in females is 2minutes and 4 minutes respectively while in males, it is 30 seconds and 3 minutes 30 seconds respectively. Minimum and maximum clotting time observed in females is 3minutes 30 seconds and 10 minutes respectively while in males, it is 2 minutes 30 seconds and 5 minutes respsectively. ConclusionOur study suggests that bleeding and clotting time are slightly higher in females. We recommend further detailed study in this area.

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Shortened bleeding time in acute myocardial infarction and its relation to platelet mass.

Abstract: The bleeding time, using the Simplate method, horizontal incision, and venostasis, was measured in a study of 51 patients admitted to a coronary care unit within 12 hours of the onset of chest pain. The

Cited by 61 publications

References 19 publications

Study of the mechanisms of aldosterone prothrombotic effect in rats

Study of the mechanisms of aldosterone prothrombotic effect in rats

Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events

Bleeding time and Clotting Time in Healthy Male and Female College Students of Karukutty Village, Kerala

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