Acetylsalicylic Acid does not Reduce the Intraocular Pressure Variation in Ocular Hypertension or Glaucoma

Lindén, Christina; Alm, Albert

doi:10.1006/exer.1999.0786

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…There was no statistically significant difference between the placebo-treated and the ASA-treated patients. 9 This is in agreement with our observation that the usage of PAIs was not associated with the IOP at follow-up. Bell et al found, in a retrospective, observational, case-control study amongst 64 patients undergoing trabeculectomy and 74 controls, an association between ASA use and an increased frequency of glaucoma surgery, suggesting a harmful effect.…”

Section: Discussionsupporting

confidence: 93%

“…6,7 For all these reasons, it seems logical to study the potential role of these drugs in the management of OAG, as suggested earlier. 8 Thus far, one study addressed the effect of PAIs (acetylsalicylic acid, ASA) on IOP, 9 and two studies examined the effect of ASA on the progression of OAG. 10,11 As these studies gave equivocal results (see Discussion section), another look at this issue seemed warranted.…”

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confidence: 99%

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Antithrombotic Medication and Incident Open-Angle Glaucoma

Marcus

Müskens

Ramdas

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Antithrombotic Medication and Incident Open-Angle Glaucoma

Marcus

Müskens

Ramdas

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…This is in keeping with the results of a randomized, crossover trial of aspirin versus placebo 32 and also in agreement with results from the Rotterdam Study, which reported that use of anticoagulants or platelet aggregation inhibitors was not associated with incident open-angle glaucoma 33 . The Rotterdam Study did report a nonsignificant trend towards lower IOP in participants taking aspirin (−0.21 mmHg; 95% CI, −0.44 to 0.01), although this was not adjusted for concurrent oral β-blocker use 33 …”

Section: Discussionsupporting

confidence: 80%

Systemic Medication and Intraocular Pressure in a British Population

Khawaja

Chan²,

Broadway

et al. 2014

Ophthalmology

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ObjectiveTo determine the association between systemic medication use and intraocular pressure (IOP) in a population of older British men and women.DesignPopulation-based, cross-sectional study.ParticipantsWe included 7093 participants from the European Prospective Investigation into Cancer–Norfolk Eye Study. Exclusion criteria were a history of glaucoma therapy (medical, laser, or surgical), IOP asymmetry between eyes of >5 mmHg, and missing data for any covariables. The mean age of participants was 68 years (range, 48–92) and 56% were women.MethodsWe measured IOP using the Ocular Response Analyzer. Three readings were taken per eye and the best signal value of the Goldmann-correlated IOP value considered. Participants were asked to bring all their medications and related documentation to the health examination, and these were recorded by the research nurse using an electronic case record form. The medication classes examined were angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, α-blockers, β-blockers, calcium channel blockers, diuretics, nitrates, statins, insulin, biguanides, sulfonylureas, aspirin, and other nonsteroidal anti-inflammatory drugs. We examined associations between medication use and IOP using multivariable linear regression models adjusted for age, sex, and body mass index. Models containing diabetic medication were further adjusted for glycosylated hemoglobin levels.Main Outcome MeasuresMean IOP of the right and left eyes.ResultsUse of systemic β-blockers (−0.92 mmHg; 95% CI, −1.19, −0.65; P<0.001) and nitrates (−0.63 mmHg; 95% CI, −1.12, −0.14; P = 0.011) were independently associated with lower IOP. The observed associations between statin or aspirin use with IOP were no longer significant after adjustment for β-blocker use.ConclusionsThis is the first population-based study to demonstrate and quantify clinically significant differences in IOP among participants using systemic β-blockers or nitrates. Lower IOP observed in participants using statins or aspirin was explained by concurrent systemic β-blocker use. The study findings may have implications for the management of glaucoma patients with comorbidity, and may provide insight into the pathophysiologic processes underlying IOP.

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“…Acetylsalicylic acid has complex effects on the changes of intraocular pressure, studies have demonstrated that single-use of acetylsalicylic acid cannot significantly reduce intraocular pressure in glaucoma patients, but long-term use will have an impact on intraocular pressure [ 39 , 40 ]. There was a distinguished effect that acetylsalicylic acid is used in combination with other drugs to treat glaucoma [ 41 ]. The glaucoma-related gene list in GeneCards only contains ENO2 among the three diagnostic markers, ENO2 was used for molecular docking.…”

Section: Discussionmentioning

confidence: 99%

Based on multiple machine learning to identify the ENO2 as diagnosis biomarkers of glaucoma

Dai

Kang

et al. 2022

BMC Ophthalmol

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Purpose Glaucoma is a generic term of a highly different disease group of optic neuropathies, which the leading cause of irreversible vision in the world. There are few biomarkers available for clinical prediction and diagnosis, and the diagnosis of patients is mostly delayed. Methods Differential gene expression of transcriptome sequencing data (GSE9944 and GSE2378) for normal samples and glaucoma samples from the GEO database were analyzed. Furthermore, based on different algorithms (Logistic Regression (LR), Random Forest (RF), lasso regression (LASSO)) two diagnostic models are constructed and diagnostic markers are screened. GO and KEGG analyses revealed the possible mechanism of differential genes in the pathogenesis of glaucoma. ROC curve confirmed the effectiveness. Results LR-RF model included 3 key genes (NAMPT, ADH1C, ENO2), and the LASSO model outputted 5 genes (IFI16, RFTN1, NAMPT, ADH1C, and ENO2), both algorithms have excellent diagnostic efficiency. ROC curve confirmed that the three biomarkers ADH1C, ENO2, and NAMPT were effective in the diagnosis of glaucoma. Next, the expression analysis of the three diagnostic biomarkers in glaucoma and control samples confirmed that NAMPT and ADH1C were up-regulated in glaucoma samples, and ENO2 was down-regulated. Correlation analysis showed that ENO2 was significantly negatively correlated with ADH1C (cor = -0.865714202) and NAMPT (cor = -0.730541227). Finally, three compounds for the treatment of glaucoma were obtained in the TCMs database: acetylsalicylic acid, 7-o-methylisomucitol and scutellarin which were applied to molecular docking with the diagnostic biomarker ENO2. Conclusions In conclusion, our research shows that ENO2, NAMPT, and ADH1C can be used as diagnostic markers for glaucoma, and ENO2 can be used as a therapeutic target.

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Acetylsalicylic Acid does not Reduce the Intraocular Pressure Variation in Ocular Hypertension or Glaucoma

Cited by 10 publications

References 12 publications

Antithrombotic Medication and Incident Open-Angle Glaucoma

Antithrombotic Medication and Incident Open-Angle Glaucoma

Systemic Medication and Intraocular Pressure in a British Population

Based on multiple machine learning to identify the ENO2 as diagnosis biomarkers of glaucoma

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