Acetylsalicylic acid induced cessation of transient ischaemic attacks and microembolic signals detected by transcranial Doppler in a patient with essential thrombocythaemia

Transcranial Doppler Findings in Myeloproliferative Diseases (Polycythemia Vera and Essential Thrombocytosis): A Systematic Review

“…Of the five studies reviewed, three were case reports wherein there were two cases of PV and one case of ET (Del Sette et al, 1995;Segura et al, 2000;Blaser et al, 2001), one was an observational study with a sample size of 20 newly diagnosed PV patients (Fiermonte et al, 1993), and another was a prospective case-control study with a sample size of 40 ET patients, age and sex-matched with 40 healthy controls (Cinar et al, 2021). In total, 63 patients were included in this review; 27 were male, and 36 were female.…”

“…In utilizing transcranial Doppler, readings were performed using various Doppler models, including the following: CW Doppler Velocimeter D800 and TC 2-64b, TCD 64 EME, DWL-multidop X4, and Sonara TCD system Care Fusion. One study did not specify the TCD machine used (Blaser et al, 2001). There was no mention of the credentials of sonographers in any of the investigations.…”

“…Meanwhile, essential thrombocytosis was diagnosed according to the WHO 2008 diagnostic criteria for ET (Cinar et al, 2021). Platelet function tests, such as template bleeding time, platelet glass retention, quantitative clot retraction, and induced platelet aggregation by ADP, were also performed (Blaser et al, 2001).…”

“…The outcomes measured across three studies investigating patients with PV were in congruence with each other. The blood velocities in the MCA were measured in 62 patients from all the studies, except one (Blaser et al, 2001), which only investigated MES. 20 subjects from Fiermonte et al's study also measured the blood velocities in the ACA, PCA, and BA.…”

Circulating microemboli in patients with myeloproliferative disorders

“…The detection of microembolic signals (MES) during transcranial Doppler sonography (TCD) monitoring has been linked with an increased risk of recurrent stroke in patients with symptomatic carotid and intracranial artery stenoses [8–10]. In MPD, the application of this technique has been reported only in single case studies describing increased rates of MES [11]; however, overall frequency and prognostic value of MES in MPD patients remain unclear.…”