Achillea millefolium inflorescence aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences

Jalali, Ali Shalizar; Hasanzadeh, Shapour; Malekinejad, Hassan

doi:10.1016/s1875-5364(12)60050-8

Cited by 39 publications

(51 citation statements)

References 41 publications

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“…Testis weight is connected with quantities of different differentiational spermatids (19). We found results here that were consistent with those in our previous work which indicated that CP exposure resulted in decreases in sperm count and survival ratio, an increased sperm abnormality ratio, as well as signifi cant reductions in body weight, testis weight and index in CP-treated mice, which also agreed with current data (3,4,9,20).…”

Section: Discussionsupporting

confidence: 92%

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Le¹,

Luo²,

Gu³

et al. 2015

BLL

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Cyclophosphamide (CP) is a commonly used antitumour and immunosuppressive drug, but it is inevitable that the chemotherapeutic agent may cause long-term or permanent reproductive damage on young male patients through inducing oxidative stress in the testes. Squid ink polysaccharides (SIP), a newly found marine glycosaminoglycon have been proved to have antioxidant capabilities and chemotherapy-protective activities on model animals in our recent investigations. This study was conducted to assess whether or not SIP could protect male mice against gonadotoxicity during CP exposure. Sexually mature male Kunming mice were allocated to one of four groups. CP was abdominally administered at dose of 15 mg/kg body weight to two groups of mice for ten weeks, once a week, one group of mice received SIP at dose of 80 mg/kg body weight by gavage for ten weeks, once a day. The other two groups comprised a vehicle treated group and an SIP treated group. Toxicity of CP and protective activity of SIP on the testes were assessed by: sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sex hormone content, and histopathological features. Data showed CP-induced, serious negative changes on murine sperm parameters, organ index, testicular antioxidant ability, activities of marker enzymes, sexual hormone contents, and histopathological features which were all signifi cantly impaired by SIP. This study found that SIP were demonstrated to offer protective effects against CP-induced toxicity on testes in mice (Tab. 2, Fig. 3, Ref. 29). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 92%

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Le¹,

Luo²,

Gu³

et al. 2015

BLL

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“…The results were expressed as equivalents of MDA in testicular tissue homogenate in µmol/g tissue (18). TAC was measured based on assessment with the ferric reduction antioxidant power assay as previously described (19), and expressed as µmol/g of tissue samples.…”

Section: Biochemical Analysis Of Testicular Tissue Homogenatementioning

confidence: 99%

“…Using an ocular micrometer with light microscopy, the GEH at 4 equidistant points of each seminiferous tubule cross-section was measured, and the mean was recorded. The STDs were measured across the minor and major axes, and their means were obtained (21).…”

Section: Morphometric Measurementsmentioning

confidence: 99%

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Hajizadeh

Mehranjani

Najafi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. However, its application carries the risk of adverse reactions, including reproductive toxicities. Grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. Objectives: This study was designed to evaluate whether hydroalcoholic grape seed extract (GSE) could ameliorate FLX-evoked oxidative injuries in the mouse testis. Materials and Methods: Thirty-two male mice were categorized into four groups of eight mice each. Two groups received FLX at a dose of 20 mg/kg per day over a period of six weeks by oral gavage. One of these groups received GSE at a dose of 100 mg/kg per day orally along with the FLX. An untreated control group and a GSE-only treated group were also included. Serum and testicular samples were collected 24 hours after the last treatment. Results: Biochemical analyses demonstrated that FLX caused significant decreases in testicular antioxidant capacity and serum testosterone concentrations, as well as lipid peroxidation elevations in testicular tissue. Morphometric and histopathological studies supported the biochemical findings. Concomitant administration of GSE with FLX markedly reduced testicular damage and significantly restored all of the mentioned markers to normal values. Conclusions:The findings suggested that oxidative stress-mediated testicular damage, arising as a result of FLX administration in mice, could be reversed by GSE.

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“…For example, Achillea millefolium aqueous extracts have been used as medicine by many cultures and have been shown to actuate in protection or attenuation of testicular damage following chemotherapies exposure [1]. However, most of them have been included in negative response.…”

Section: Introductionmentioning

confidence: 99%

Risk of plant extracts in rat reproduction

Costa¹,

Bezerra²,

Correia³

et al. 2017

Med Res Innov

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Achillea millefolium inflorescence aqueous extract ameliorates cyclophosphamide-induced toxicity in rat testis: stereological evidences

Cited by 39 publications

References 41 publications

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Interventional effects of squid ink polysaccharides on cyclophosphamide-associated testicular damage in mice

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Risk of plant extracts in rat reproduction

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