Achillea santolina reduces serum interlukin-6 level and hyperalgesia during complete Freund's adjuvant-induced inflammation in male Wistar rats

Zaringhalam, Jalal; Akbari, Akhtar; Tekieh, Elaheh; Manaheji, Homa; Rezazadeh, Shamsali

doi:10.3736/jcim20101211

Cited by 22 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The inflammatory pain model employed in this study has been widely used to test several analgesic drugs,18 including drugs with anti-inflammatory activity 8. Tissue damage or inflammation leads to the release of a variety of inflammatory mediators – such as histamine, serotonin, arachidonic acid metabolites (via cyclooxygenase), and kinin – from leukocytes migrating to the affected region 19.…”

Section: Discussionmentioning

confidence: 99%

“…CFA-induced inflammation is commonly recommended as an acute and chronic animal inflammation model for the study of therapeutic approaches to pain 8. Briefly, animals were anesthetized with isoflurane, and inflammation was induced by a single intradermal injection of 100 μl CFA (heat-killed Mycobacterium tuberculosis suspended in paraffin oil, plus mannide monooleate, 1 mg/1 mL) into the right hind paw.…”

Section: Methodsmentioning

confidence: 99%

“…Among the broad range of effects attributed to melatonin, its potential antinociceptive and anti-inflammatory actions have been studied in an animal model of acute pain 4. The analgesic properties of melatonin have been demonstrated in previous studies conducted by our group5,6 and in other studies of patients with fibromyalgia 7,8. Melatonin administration has been found to raise pain thresholds 9.…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Melatonin administration reduces inflammatory pain in rats

Laste¹,

Macedo²,

Rozisky³

et al. 2012

JPR

View full text Add to dashboard Cite

In view of the broad range of effects attributed to melatonin, this study evaluated its analgesic effect on inflammatory pain induced by complete Freund’s adjuvant (CFA) in Wistar rats. Inflammation was induced by intradermal CFA injection in the hind paw of all animals, which were then divided into two groups that received either 60 mg/kg of melatonin or vehicle (1% alcohol in saline), intraperitoneally, for three days. The analgesic effect of melatonin was assessed by the hot-plate test, immediately and thereafter at 30, 60, 90, and 120 minutes after the first administration and 24 hours after once-daily administration for 2 more days. After CFA injection, melatonin administration increased withdrawal latency at 60 minutes after the first dose. After the end of treatment, melatonin showed a significant analgesic effect on inflammatory pain. This study paves the way for exploration of how brief courses of treatment could improve this analgesic effect in the late phases of inflammatory pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Melatonin administration reduces inflammatory pain in rats

Laste¹,

Macedo²,

Rozisky³

et al. 2012

JPR

View full text Add to dashboard Cite

show abstract

“…The samples were centrifuged and stored at –80°C. The collected serum showed 100% cross-reactivity with the ELISA kit (Zaringhalam, Akbari, Tekieh, Manaheji, & Shamsali, 2010). …”

Section: Methodsmentioning

confidence: 99%

Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis

Zaringhalam¹,

Akbari²,

Zali³

et al. 2016

BCN

View full text Add to dashboard Cite

Introduction:Immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. Given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin B1 on the proinflammatory cytokines, edema, and hyperalgesia during the acute and chronic phases of adjuvant-induced arthritis.Methods:On the first day of study, inflammation was induced by intraplantar injection of complete Freund's adjuvant (CFA) in the hindpaws of rats. Vitamin B1 at doses of 100, 150, and 200 mg/kg was administrated intraperitoneally during 21 days of the study. Antinociceptive and anti-inflammatory effects of vitamin B1 were also compared to indomethacin (5 mg/kg). Inflammatory symptoms such as thermal hyperalgesia and paw edema were measured by radiant heat and plethysmometer, respectively. Serum TNF-α and IL-1β levels were checked by rat standard enzyme-linked immune sorbent assay (ELISA) specific kits.Results:The results indicated that vitamin B1(150 and 200 mg/kg) attenuated the paw edema, thermal hyperalgesia, and serum levels of TNF-α and IL-1β during both phases of CFA-induced inflammation in a dose-dependent manner. Effective dose of vitamin B1(150 mg/kg) reduced inflammatory symptoms and serum levels of TNF-α and IL-1β compare to indomethacin during the chronic phase of inflammation.Conclusion:Anti-inflammatory and antihyperalgesic effects of vitamin B1 during CFA-induced arthritis, more specifically after chronic vitamin B1 administration, suggest its therapeutic property for inflammation.

show abstract

“…millefolium demonstrates in vitro anti-inflammatory activity by decreasing HNE and inhibiting MMP-2 and 9 (Table 2) [28]. A. ageratum and A. santolina exhibit anti-inflammatory activity in vivo by decreasing IL-6, MPO level, and suppressing neutrophil migration into inflamed tissue [29,30]. A. fragrantissima shows anti-inflammatory activity by decreasing MMP-9 levels and inhibiting IL-1β, COX-2, NO, iNOS, and TNFα production [31].…”

Section: Achillea Millefoliummentioning

confidence: 97%

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Farzaei

Gooshe

et al. 2014

Rheumatol Int

View full text Add to dashboard Cite

Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA.

show abstract

Achillea santolina reduces serum interlukin-6 level and hyperalgesia during complete Freund's adjuvant-induced inflammation in male Wistar rats

Cited by 22 publications

References 26 publications

Melatonin administration reduces inflammatory pain in rats

Melatonin administration reduces inflammatory pain in rats

Long-Term Treatment by Vitamin B1 and Reduction of Serum Proinflammatory Cytokines, Hyperalgesia, and Paw Edema in Adjuvant-Induced Arthritis

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Contact Info

Product

Resources

About