Achromobacter: an emerging nosocomial pathogen

Pandey, Kxitiza; Nautiyal, Sulekha

doi:10.18203/2320-6012.ijrms20193400

Cited by 6 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of Achromobacter spp. bacteremia encountered in this study was 0.57 % (14/2435, 0.57 %), which corroborates with a study by Pandey et al [16], which illustrated an incidence of Achromobacter spp. infections as 0.46 % (63/13831, 0.46 %).…”

Section: Discussionsupporting

confidence: 93%

One year experience of Achromobacter bacteremia at a tertiary care hospital in Northern India

Kar,

Singh,

Tejan

et al. 2023

Access Microbiology

View full text Add to dashboard Cite

Introduction. Achromobacter is a Gram-negative, motile, obligate aerobic and non-fermentative bacterium. It is an emerging pathogen in the hospital environment as it is frequently found in various solutions. Hypothesis/Gap Statement. Information about the incidence and risk factors of Achromobacter bacteremia from India is limited. Aim. We conducted this study to identify the risk factors and underlying conditions predisposing to bacteremia by Achromobacter spp. and analyse the antibiotic resistance pattern of the isolates. Methodology. We performed a retrospective observational study where automated blood cultures positive for Achromobacter spp. were assessed for clinical characteristics and antibiotic susceptibility patterns from January 2022 to December 2022 in the microbiology laboratory of a tertiary care centre in Northern India. Results. A total of 14 cases (14/2435, 0.57 %) of Achromobacter spp. were identified from bloodstream infections in one year. The mean age of the patients was 37.59±23.17 years with a male predominance (8/14, 57.1 %). All patients were managed on intravenous antibiotics and intravenous access as peripheral line catheters and only 5(5/14, 35.7 %) patients were managed on central line catheters. The isolates were found highly susceptible to ticarcillin-clavulanic acid (14/14, 100.0 %) followed by fluoroquinolones (12/14, 85.72 %) and trimethoprim-sulphamethoxazole (12/14, 85.72 %). Only 57.14 % (8/14, 57.14 %) of the patients were susceptible to piperacillin-tazobactam. The all-cause 40 day mortality was observed in 35.7 % (5/14, 35.7 %) with two deaths that were directly attributable to sepsis. Conclusion. This study provides insight into the incidence of Achromobacter bacteremia at our centre and the necessary antibiotic therapy to combat it.

show abstract

Section: Discussionsupporting

confidence: 93%

One year experience of Achromobacter bacteremia at a tertiary care hospital in Northern India

Kar,

Singh,

Tejan

et al. 2023

Access Microbiology

View full text Add to dashboard Cite

show abstract

“…Regarding the in vitro antimicrobial susceptibility of the isolates in our study, they were susceptible to piperacillin/tazobactam (87.5%), ceftazidime (81.25%), trimethoprim/sulfamethoxazole (75%), and meropenem (75%), and most were resistant to ampicillin, most cephalosporins, aminoglycosides, and fluoroquinolones. These results are in agreement with Pandey et al [20], Shie et al [17], De Fernandez et al [21], and other reports [6, 18, 22, and 23]. Thus, antimicrobial susceptibility information is crucial when making therapeutic decisions, especially for IC and critically ill patients.…”

Section: Figure 1 Distribution Of Positive Microbial Isolatessupporting

confidence: 92%

Achromobacter species, an emerging cause of bacteremia in tertiary healthcare facilities in Egypt

Newishy¹,

Sherif²,

Elnakib³

et al. 2022

GSC Adv. Res. Rev.

View full text Add to dashboard Cite

During our laboratory routine, we detected Gram-negative, motile, aerobic, oxidase- and catalase-positive, lactose non-fermenting bacilli during microbial isolation from blood cultures of immune compromised patients. Our study investigates this phenomenon. Blood culture results from 1000 samples were taken during febrile attacks in immune compromised patients in adult intensive care units (AICUs), pediatric and neonatal intensive care units (PICUs and NICUs, respectively), liver and kidney departments, and oncology and hematology departments in a tertiary healthcare facility in Cairo, Egypt. The blood cultures were processed in the microbiology laboratory and incubated in an automated system. An automated system was also used to identify the species in positive cultures and perform antimicrobial susceptibility testing. Achromobacter sp. were identified and isolated according to their morphological and biochemical characteristics. Of one thousand blood cultures performed, 310 were positive (Gram-negative: 195, 63%; Gram-positive: 105, 34%; fungi: 10, 3%). Of these positive cultures, 16 (5.2%) were positive for Achromobacter sp., the most common being Achromobacter xylosoxidans (15/16, 93.75%), while A. dentrificans was identified in one case (6.25%). Among those affected, 37.5% were patients with hematological malignancies, 6.25% had organ transplants, 56.5% were in the ICUs (25% were in AICU, 18.8% in the PICU, and 12.5% in the NICU). Achromobacter sp. were resistant to cefepime, aminoglycosides, and fluoroquinolones. Central venous catheter infection occurred in 13 (81.25%) cases. Our findings open discussion concerning Achromobacter sp. as an opportunistic pathogen in immune compromised patients and contribute to the development of future treatment approaches.

show abstract

“…The increased abundance of genus Vibrio in the intestine of hybrid grouper was observed [ 40 ]. The genus Achromobacter is considered opportunistic pathogens of low virulence in humans [ 67 ] and the genus Vibrio , such as Vibrio anguallanim , is another opportunistic pathogen that can cause hemorrhagic septicemia and vibriosis in many fish species [ 68 ]. Furthermore, the intestinal abundance was highest, respectively, in SBM diets for the former and in 10% glycinin diets for the latter among the treatments ( Figure 8 A) in this study.…”

Section: Discussionmentioning

confidence: 99%

Dietary High Glycinin Reduces Growth Performance and Impairs Liver and Intestinal Health Status of Orange-Spotted Grouper (Epinephelus coioides)

Yin

Zhao

Yang

et al. 2023

Animals

View full text Add to dashboard Cite

The aim of the study was to investigate whether the negative effects of dietary glycinin are linked to the structural integrity damage, apoptosis promotion and microbiota alteration in the intestine of orange-spotted grouper (Epinephelus coioides). The basal diet (FM diet) was formulated to contain 48% protein and 11% lipid. Fish meal was replaced by soybean meal (SBM) in FM diets to prepare the SBM diet. Two experimental diets were prepared, containing 4.5% and 10% glycinin in the FM diets (G-4.5 and G-10, respectively). Triplicate groups of 20 fish in each tank (initial weight: 8.01 ± 0.10 g) were fed the four diets across an 8 week growth trial period. Fish fed SBM diets had reduced growth rate, hepatosomatic index, liver total antioxidant capacity and GSH-Px activity, but elevated liver MDA content vs. FM diets. The G-4.5 exhibited maximum growth and the G-10 exhibited a comparable growth with that of the FM diet group. The SBM and G-10 diets down-regulated intestinal tight junction function genes (occludin, claudin-3 and ZO-1) and intestinal apoptosis genes (caspase-3, caspase-8, caspase-9, bcl-2 and bcl-xL), but elevated blood diamine oxidase activity, D-lactic acid and endotoxin contents related to intestinal mucosal permeability, as well as the number of intestinal apoptosis vs FM diets. The intestinal abundance of phylum Proteobacteria and genus Vibrio in SBM diets were higher than those in groups receiving other diets. As for the expression of intestinal inflammatory factor genes, in SBM and G-10 diets vs. FM diets, pro-inflammatory genes (TNF-α, IL-1β and IL-8) were up-regulated, but anti-inflammatory genes (TGF-β1 and IL-10) were down-regulated. The results indicate that dietary 10% glycinin rather than 4.5% glycinin could decrease hepatic antioxidant ability and destroy both the intestinal microbiota profile and morphological integrity through disrupting the tight junction structure of the intestine, increasing intestinal mucosal permeability and apoptosis. These results further trigger intestinal inflammatory reactions and even enteritis, ultimately leading to the poor growth of fish.

show abstract

Achromobacter: an emerging nosocomial pathogen

Cited by 6 publications

References 20 publications

One year experience of Achromobacter bacteremia at a tertiary care hospital in Northern India

One year experience of Achromobacter bacteremia at a tertiary care hospital in Northern India

Achromobacter species, an emerging cause of bacteremia in tertiary healthcare facilities in Egypt

Dietary High Glycinin Reduces Growth Performance and Impairs Liver and Intestinal Health Status of Orange-Spotted Grouper (Epinephelus coioides)

Contact Info

Product

Resources

About