Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway

Fu, Changlong; Qiu, Zhiwei; Huang, Yanfeng; Lin, Qing; Jin, Linglu; Tu, Haishui; Ye, Jinxia; Zheng, Chengchao; Zhong, Weihong; Ma, Dezun

doi:10.1016/j.biopha.2022.113551

Cited by 18 publications

(12 citation statements)

References 23 publications

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“…It has been reported that endoplasmic reticulum oxidative stress occurs in articular chondrocytes of OA patients, which promotes apoptosis of chondrocytes ( Bian et al, 2018 ), ( Cao et al, 2018 ). After treatment with antioxidants, they can protect the chondrocytes, thus alleviating disease ( Fu et al, 2022 ), ( Hecht et al, 2021 ), ( Lin et al, 2021 ). Therefore, we conducted a further study on the causes of endoplasmic reticulum stress.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, the possible pathogenesis is mainly focused on endoplasmic reticulum stress of chondrocytes ( Cao et al, 2018 ). In addition, many studies have found that some traditional Chinese medicine extracts can alleviate the pain of osteoarthritis patients by reducing the endoplasmic reticulum stress of chondrocytes ( Fu et al, 2022 ) , ( Bian et al, 2018 ), but they still have not achieved the goal of targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

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Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Zhang¹,

Li²,

Yuan³

et al. 2022

Front. Pharmacol.

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Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients’ physical and mental health and reduces their quality of life. At present, the pathogenesis of osteoarthritis is not completely clear, and the treatment plan is mainly to relieve symptoms and ensure basic quality of life. Therefore, it is particularly urgent to explore the pathogenesis of osteoarthritis. Protein, as organic macromolecule which plays a major role in life activities, plays an important role in the development of disease. Through protein omics, this study found that with the increase of age, excessive sulfur oxidation occurred in endoplasmic reticulum of chondrocytes, which then drove the occurrence of inflammatory reaction, and provided a direction for the follow-up molecular targeted.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Zhang¹,

Li²,

Yuan³

et al. 2022

Front. Pharmacol.

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“…The specific effect of chondrocyte proliferation on cartilage destruction in pathological conditions of OA remains to be explored. Additionally, studies in vivo and in vitro demonstrate that ABPS regulates the ceRNA regulating network consisting of lncRNA NRAT1 and miR‐377‐3p, thus suppressing ER stress‐induced chondrocyte apoptosis (Fu, Qiu, Huang, Lin, et al, 2022; Table 5).…”

Section: Methodsmentioning

confidence: 99%

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

Su,

Yu,

Wang

et al. 2023

Phytotherapy Research

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Osteoarthritis (OA) is a degenerative joint disease that affects millions globally. The present nonsteroidal anti‐inflammatory drug treatments have different side effects, leading researchers to focus on natural anti‐inflammatory products (NAIPs). To review the effectiveness and mechanisms of NAIPs in the cellular microenvironment, examining their impact on OA cell phenotype and organelles levels. Additionally, we summarize relevant research on drug delivery systems and clinical randomized controlled trials (RCTs), to promote clinical studies and explore natural product delivery options. English‐language articles were searched on PubMed using the search terms “natural products,” “OA,” and so forth. We categorized search results based on PubChem and excluded “natural products” which are mix of ingredients or compounds without the structure message. Then further review was separately conducted for molecular mechanisms, drug delivery systems, and RCTs later. At present, it cannot be considered that NAIPs can thoroughly prevent or cure OA. Further high‐quality studies on the anti‐inflammatory mechanism and drug delivery systems of NAIPs are needed, to determine the appropriate drug types and regimens for clinical application, and to explore the combined effects of different NAIPs to prevent and treat OA.

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“…Fu and his colleagues demonstrated through in vitro and in vivo experiments that ABPS regulates the expression of the lncRNAs NEAT1 and MiR-377-3p to inhibit ERS in chondrocytes. Likewise, both the lncRNA NEAT1-related gene set and the miR-377-3p restraint can weaken the restorative impact of ABPS on trauma centers ( 117 ).…”

Section: Lncrna-related Therapymentioning

confidence: 99%

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

Zhang,

Xie

et al. 2024

Front. Med.

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Osteoarthritis (OA) is a degenerative disease of cartilage that affects the quality of life and has increased in morbidity and mortality in recent years. Cartilage homeostasis and dysregulation are thought to be important mechanisms involved in the development of OA. Many studies suggest that lncRNAs are involved in cartilage homeostasis in OA and that lncRNAs can be used to diagnose or treat OA. Among the existing therapeutic regimens, lncRNAs are involved in drug-and nondrug-mediated therapeutic mechanisms and are expected to improve the mechanism of adverse effects or drug resistance. Moreover, targeted lncRNA therapy may also prevent or treat OA. The purpose of this review is to summarize the links between lncRNAs and cartilage homeostasis in OA. In addition, we review the potential applications of lncRNAs at multiple levels of adjuvant and targeted therapies. This review highlights that targeting lncRNAs may be a novel therapeutic strategy for improving and modulating cartilage homeostasis in OA patients.

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Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway

Cited by 18 publications

References 23 publications

Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

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