Acid–base characterization, coordination properties towards copper(II) ions and DNA interaction studies of ribavirin, an antiviral drug

Nagaj, Justyna; Starosta, Radosław; Jeżowska‐Bojczuk, Małgorzata

doi:10.1016/j.jinorgbio.2014.09.019

Cited by 21 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decolorization effect due to the energy transition of molecular interactions, which is usually associated with a red shift of the absorption peak, indicated that molecules have been inserted into the base pairs of DNA. The hyperchromic effect refers to binding of the drug and DNA in the groove . As shown in Figure , the characteristic absorption peak of DNA was found at 260 nm.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking

et al. 2019

View full text Add to dashboard Cite

The over-use of antibiotics has caused a number of problems such as contamination of antibiotic residues and virus resistance, and therefore has attracted global attention. In this study, spectroscopic techniques and molecular docking were employed to predict conformational changes and binding interaction between two cephalosporins (cefaclor and cefixime) and calf thymus DNA (ctDNA). Fluorescence and UV-vis spectra suggested that static quenching was predominant and cephalosporin bound to the groove region of ctDNA. Binding parameters calculated by the Stern-Volmer and Scatchard equations showed that cephalosporin bound to ctDNA with a binding affinity in the order of 10 3 L mol −1 . Thermodynamic parameters further indicated that the reaction was a spontaneous process driven by enthalpy and entropy, and that the main binding force was an electrostatic force. The effects of iodide, denaturant, thermal denaturation and pH on a cephalosporin-Hoechst-DNA complex were also studied, and the results confirmed that cephalosporin bound to the groove area of DNA.Finally, these results were further confirmed by molecular docking and electrochemical studies.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The complexation of molecules that are employed against HCV, such as ribavirin (1,β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, RBV), was also investigated. In more detail, complexes of RBV with Cu(II),whose hepatic and serum concentration significantly increases due to a HCV infection, were studied [ 18 ]. The coordination, elucidated by spectroscopic studies and DFT calculations, occurs via triazole N4 and amide oxygen atoms [ 18 ].…”

Section: Chemical Properties Of Metal Drugsmentioning

confidence: 99%

“…In more detail, complexes of RBV with Cu(II),whose hepatic and serum concentration significantly increases due to a HCV infection, were studied [ 18 ]. The coordination, elucidated by spectroscopic studies and DFT calculations, occurs via triazole N4 and amide oxygen atoms [ 18 ].…”

Section: Chemical Properties Of Metal Drugsmentioning

confidence: 99%

Metal-Based Compounds in Antiviral Therapy

et al. 2022

View full text Add to dashboard Cite

In recent years, the study of metal complexes and metal-based nanomaterials has aroused particular interest, leading to the promotion of new effective systems for the abatement of various viral diseases. Starting from the analysis of chemical properties, this review focuses on the employment of metal-based nanoparticles as antiviral drugs and how this interaction leads to a substantial enhancement in antiviral activity. The use of metal-based antiviral drugs has also spread for the formulation of antiviral vaccines, thanks especially to the remarkable adjuvant activities of some of the metal complexes. In particular, the small size and inert nature of Au- and Ag-based nanoparticles have been exploited for the design of systems for antiviral drug delivery, leading to the development of specific and safe therapies that lead to a decrease in side effects.

show abstract

“…[3][4][5] Moreover, metal complexes of some drugs, such as antibacterial and antiviral agents, show stronger activities than their free-forms, [6][7][8][9][10][11][12][13] perhaps due to the metal ion stabilized drug binding with the target microbial DNA. [8][9][10][11] Metal complexes of the above drugs form under physiological pH and ionic strength conditions. Therefore, understanding the biotransformation, biodistribution and pharmacological actions of drugs requires investigating the complexation behavior and/or potential between a metal ion and the drug under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Complexation Interactions between Metal Ions and Drugs under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge

et al. 2019

View full text Add to dashboard Cite

A high-throughput screening method for the complexation between metal ions and drugs was established by combining solid-phase extraction (SPE) using a nitrilotriacetic acid (NTA) modified silica spin-cartridge with subsequent HPLC analysis. First, a test metal ion solution was passed through the NTA cartridge, then a test drug solution diluted in phosphate buffered saline (pH 7.4) was passed through the metal-chelated NTA cartridge. The complexation behavior between the metal and the drug on the NTA cartridge was evaluated by HPLC quantification of the drug in the SPE eluate. Comprehensive analysis of the complexation behavior between eleven different metal ions and fifty-five drugs showed that Cu 2+ , Ni 2+ , Co 2+ , Zn 2+ , Cr 3+ and Fe 3+ formed complexes with 12, 5, 4, 2, 1 and 1 kinds of drugs, respectively. Bromazepam selectively formed complexes with Cu 2+ , Ni 2+ and Co 2+ .

show abstract

Acid–base characterization, coordination properties towards copper(II) ions and DNA interaction studies of ribavirin, an antiviral drug

Cited by 21 publications

References 49 publications

Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking

Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking

Metal-Based Compounds in Antiviral Therapy

Analysis of Complexation Interactions between Metal Ions and Drugs under Pseudo-physiological pH Conditions by a High-throughput Screening Method Using a Solid-phase Extraction Cartridge

Contact Info

Product

Resources

About