Acid-catalyzed synthesis of imidazole derivatives via N-phenylbenzimidamides and sulfoxonium ylides cyclization

Recent advances in the synthesis of imidazoles

“…For example, Tian et al reported the synthesis of substituted imidazole 50 from the reaction of imidamides 49 with sulphoxonium ylides 48 in the presence of trifluoroacetic acid (Scheme 11a). 30 The resultant imidazoles were substituted at the 1, 2 and 4-positions. In contrast, Wang and co-workers reported that the reaction of imidamides 52 with propargyl aldehydes in the presence of a boronic acid afforded 1,2,5-substituted imidazoles in which the boronic acid has transferred its substituent to the C-5′ position (Scheme 11b).…”

One-pot synthesis, NMR, quantum chemical approach, molecular docking studies, drug-likeness and in-silico ADMET prediction of novel 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(furan-2-yl)-4,5-diphenyl-1H-imidazole derivatives

“…Imidazole shows a wide spectrum of biological activities like antibacterial [10] , antagonist [11] , anti-cancer [12] , anti-viral and anti-inflammatory [13] , anti-oxidant [14] , antifungal [15] , cytotoxicity [16] . This imidazole shows great applications in natural compounds such as histamine [17] , algeacidal [18] , pilocarpine alkaloids [19] . In the imidazole skeleton which contain drugs are losartan (antihypertension), etomidate (hypnotic agent) and flumazenil [20] .…”

Synthesis, crystal structure, Hirshfeld surface analysis, DFT, molecular docking and molecular dynamic simulation studies of (E)-2,6-bis(4-chlorophenyl)-3-methyl-4-(2-(2,4,6-trichlorophenyl)hydrazono)piperidine derivatives

“…Hydrazone compound are the current interest in many chemical processes such as sensors, pharmaceutical activities and nonlinear optical materials due to its high value in hyperpolarizability [19] , [20] . Therefore, the presence of N-N and C=N bonds in the skeleton of hydrazones have so much attraction from various researchers as they possess many applications in pharmaceutical, biological and various applications in industrial chemistry such as anti-inflammatory, antioxidant, antitumor, anti-tuberculosis, analgesic, antiviral, anticancer, antimicrobial and insecticidal activities [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] .…”