Acid–degradable carboxymethyl chitosan nanogels via an ortho ester linkage mediated improved penetration and growth inhibition of 3-D tumor spheroids in vitro

Zha, Qian; Wang, Xin; Cheng, Xu; Fu, Shengxiang; Yang, Guanqing; Yao, Weijing

doi:10.1016/j.msec.2017.04.098

Cited by 47 publications

(12 citation statements)

References 37 publications

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“…pH-responsive nanoparticles have also been developed by conjugating nanocarriers with acid-labile linkage such as hydrazone [ 35 , 36 ], orthoester [ 37 , 38 ], imine [ 39 , 40 ], phosphoramidate [ 41 ], whose hydrolysis ensures rapid the release of the drug. Liao et al [ 42 ] have reported the synthesis of tumor targeting and pH-responsive nanoparticles for the enhanced delivery of DOX.…”

Section: Targeting Of Common Attributes Of Tmementioning

confidence: 99%

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

2018

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BackgroundCancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors.Main bodyThe recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo.ConclusionTumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy.

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Section: Targeting Of Common Attributes Of Tmementioning

confidence: 99%

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

2018

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“…The design of such PH stimuli-responsive nanohydrogels provides a new idea for drug slow release and delivery. Lactic acid-modified carboxymethyl chitosan methacrylate was cross-linked with ortho-methacrylate monomer to prepare pH-sensitive, tumor-targeting bifunctional nanogels, which improved the growth inhibition and penetration of tumor cells in vitro [ 61 ]. This pH-induced drug-release behavior improved its tumor-targeting ability and is expected to be a tumor drug delivery vehicle ( Figure 6 C).…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Zhang

et al. 2022

Polymers

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Chitosan is a biodegradable natural polymer derived from the exoskeleton of crustaceans. Because of its biocompatibility and non-biotoxicity, chitosan is widely used in the fields of medicine and agriculture. With the latest technology and technological progress, different active functional groups can be connected by modification, surface modification, or other configurations with various physical, chemical, and biological properties. These changes can significantly expand the application range and efficacy of chitosan polymers. This paper reviews the different uses of chitosan, such as catheter bridging to repair nerve broken ends, making wound auxiliaries, as tissue engineering repair materials for bone or cartilage, or as carriers for a variety of drugs to expand the volume or slow-release and even show potential in the fight against COVID-19. In addition, it is also discussed that chitosan in agriculture can improve the growth of crops and can be used as an antioxidant coating because its natural antibacterial properties are used alone or in conjunction with a variety of endophytic bacteria and metal ions. Generally speaking, chitosan is a kind of polymer material with excellent development prospects in medicine and agriculture.

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“…It is well understood that, among amino acids, Histidine [84]. Moreover, the pH-responsive NPs have also been developed by conjugating nanocarriers with some other acid-labile linkages such as orthoester [85,86], imine [87,88], phosphoramidate [89], whose hydrolysis ensured rapid release of the drug at the targeted tumor. xenograft models.…”

Section: Block Copolymersmentioning

confidence: 99%

pH-Sensitive Nanomedicine for Treating Gynaecological Cancers

Prasad

Purkayastha

Sharma

et al. 2020

JWRH

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Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine.Nonetheless, theside-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

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Acid–degradable carboxymethyl chitosan nanogels via an ortho ester linkage mediated improved penetration and growth inhibition of 3-D tumor spheroids in vitro

Cited by 47 publications

References 37 publications

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

pH-Sensitive Nanomedicine for Treating Gynaecological Cancers

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