Acid-responsive composite hydrogel platform with space-controllable stiffness and calcium supply for enhanced bone regeneration

Bao, Ziting; Gu, Zhipeng; Xu, Jiahua; Zhao, Meng; Liu, Guiting; Wu, Jun

doi:10.1016/j.cej.2020.125353

Cited by 51 publications

(36 citation statements)

References 31 publications

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“…The versatility of HA lends itself to fabricating composite materials with highly tunable physical, chemical, and biological properties. [ 56–64 ] HA‐reinforced gelatin hydrogels offer promising material performance for tissue engineering and regenerative medicine technologies.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Suvarnapathaki

Lantigua

et al. 2020

Macromolecular Bioscience

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require mechanically strong scaffolds to support cell differentiation and mineral deposition. [8-10] The commonly used biomaterials, such as ceramics and metals, are mechanically robust but are compatible with only certain cell cultures. Despite relatively weak mechanical properties, hydrogels exhibit exceptional biomimetic properties and material tunability. [11,12] The spatial and temporal control found in hydrogel synthesis approaches also assists in generating modular mechanical and chemical properties. These aspects enable the generation of scaffolds that mimic the native tissue microenvironment. [13,14] Across all human tissue types, cells are sensitive and responsive to mechanical stresses and stiffnesses, including compression, tension, and shear. [15] Typically, the stiffness of hydrogels can be modified by adjusting the prepolymer concentration and the cross-linking time. [16,17] These techniques can result in stiffer hydrogels but lead to limitations in the biological performance of the material. These limitations have necessitated innovative approaches such as reinforcing hydrogels with nano/microfibers in various weaving patterns. [18,19] Another approach to improve the mechanical and biological properties of hydrogels simultaneously is to process these composite materials at higher cross-linking densities. The mechanical properties have been demonstrated to affect cell migration and tissue morphogenesis within the material. [8] More recently, hydroxyapatite ((HA), Ca 10 (PO 4) 6 (OH) 2), silver, and gold nanoparticles have been incorporated into hydrogels to enhance the scaffold's mechanical capabilities and cytocompatibility. [20,21] In previous works, HA has been used as a filling material to fabricate biocompatible matrices in orthopedic and mineralized implants. [22-24] HA has a natural tendency to bind to osseous tissues and its physical properties are similar to that of the native minerals in the human body. [22,25-29] The success of HApolymer composite materials has offered advanced and desirable qualities in biomimetic and mechanically competent bone tissue engineering scaffolds. [30] In the past, different forms of tissue scaffolds were fabricated using HA, such as electrospun fibers, 3D printed thermoplastic polymers, and freeze-dried matrices. [31-34] In our work, we have generated HA-reinforced, hydrogel-based scaffolds which have high water content and have biomimetic properties. Reinforcing polymeric scaffolds with micro/nanoparticles improve their mechanical properties and render them bioactive. In this study, hydroxyapatite (HA) is incorporated into 5% (w/v) gelatin methacrylate (GelMA) hydrogels at 1, 5, and 20 mg mL −1 concentrations. The material properties of these composite gels are characterized through swelling, degradation, and compression tests. Using 3D cell encapsulation, the cytocompatibility and osteogenic differentiation of preosteoblasts are evaluated to assess the biological properties of the composite scaffolds. The in vitro assays demonstrate increasing cell prolife...

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Section: Discussionmentioning

confidence: 99%

Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Suvarnapathaki

Lantigua

et al. 2020

Macromolecular Bioscience

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“…Based on the responsive stimuli, smart hydrogels could be divided into physical, chemical, and biochemical responsive hydrogels. They are extensively applied in biomedical fields, including therapeutic delivery ( Liang Y. et al, 2019 ), contact lenses ( Alvarez-Rivera et al, 2018 ), corneal prosthesis ( Koivusalo et al, 2019 ), wound healing ( Zhang et al, 2020 ), bone regeneration ( Bao et al, 2020 ), and tissue engineering ( Kaiser et al, 2019 ; Tresoldi et al, 2019 ; George et al, 2020 ; Wang et al, 2020 ).…”

Section: Smart Hydrogel In Biomedical Applicationmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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“…Nano) was used to analyze the particle size, size distribution, and polydispersity index of the nanoparticles [38][39][40].…”

Section: Characterization Of Pmn/gly and Lch@pmn/glymentioning

confidence: 99%

“…Overall, PMN/GLY demonstrated higher tensile modulus and elongation than LCH, PMN/GLY and LCH@PMN/GLY, however it exhibited lower maximum strength. Therefore, exibility would be an important consideration for the application of LCH@PMN/GLY nanocomposites for various types of wound surface [35][36][37][38].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

et al. 2021

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The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The in uences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial e cacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These ndings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

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Acid-responsive composite hydrogel platform with space-controllable stiffness and calcium supply for enhanced bone regeneration

Cited by 51 publications

References 31 publications

Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Hydroxyapatite‐Incorporated Composite Gels Improve Mechanical Properties and Bioactivity of Bone Scaffolds

Rational Design of Smart Hydrogels for Biomedical Applications

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

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