Rational Design of Smart Hydrogels for Biomedical Applications

Zhang, Yanyu; Huang, Yishun

doi:10.3389/fchem.2020.615665

Cited by 87 publications

(52 citation statements)

References 188 publications

(88 reference statements)

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“…It is worth mentioning that not all the Fmoc-modified dipeptides form hydrogels in specific conditions, and most of those dipeptides generally form hydrogels at low pH, which limited the applications in biomedical eras ( Fichman and Gazit, 2014 ; Hendi et al, 2020 ; Zhang and Huang, 2021 ). Inspired by the success of Fmoc-modified dipeptide hydrogelators, various aromatic moieties, such as phenyl, naphthalene (Nap), azobenzene, and pyrene derivatives, have been utilized to augment the hydrogelation or to introduce functionality at the N-terminus of dipeptide ( Fleming and Ulijn, 2014 ).…”

Section: Cooh-terminal and N-terminal Modified Dipeptidementioning

confidence: 99%

Self-Assembly Dipeptide Hydrogel: The Structures and Properties

Zheng

et al. 2021

Front. Chem.

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Self-assembly peptide-based hydrogels are well known and popular in biomedical applications due to the fact that they are readily controllable and have biocompatibility properties. A dipeptide is the shortest self-assembling motif of peptides. Due to its small size and simple synthesis method, dipeptide can provide a simple and easy-to-use method to study the mechanism of peptides’ self-assembly. This review describes the design and structures of self-assembly linear dipeptide hydrogels. The strategies for preparing the new generation of linear dipeptide hydrogels can be divided into three categories based on the modification site of dipeptide: 1) COOH-terminal and N-terminal modified dipeptide, 2) C-terminal modified dipeptide, and 3) uncapped dipeptide. With a deeper understanding of the relationship between the structures and properties of dipeptides, we believe that dipeptide hydrogels have great potential application in preparing minimal biocompatible materials.

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Section: Cooh-terminal and N-terminal Modified Dipeptidementioning

confidence: 99%

Self-Assembly Dipeptide Hydrogel: The Structures and Properties

Zheng

et al. 2021

Front. Chem.

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“…Three-dimensional cross-linked polymeric structures that love water are called hydrogels [1][2][3], and those that respond to external stimuli (such as pH, temperature, ionic strength, electric field, light, magnetic field, and so forth) as volume changes are called smart or intelligent or stimuli-responsive hydrogels [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…These gels are used in biological sensing, drug release and tissue degeneration, artificial muscles, micro-electromechanical-system instruments such as microvalves, and microfluidity controllers. In addition to these, diapers, irrigation, and smart windows can be given as examples in daily life [11][12][13][14][15]. In the temperature-responsive gels, when the temperature rises above a certain value, phase separation occurs, and the gel shrinks.…”

Section: Introductionmentioning

confidence: 99%

“…Below the LCST, the compatibility of the gel with water increases, and swelling is observed. This is explained by the strengthening of hydrogen bonds between water molecules and hydrophilic groups [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…The resulting positive charges repel each other, water diffusion is achieved, and swelling is observed in the gel. This swelling shrinkage transition pH is called the inflection point (IP) [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

Işıkver

Saraydın

2021

Gels

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Smart hydrogels (SH) were prepared by thermal free radical polymerization of N-isopropyl acrylamide (NIPAAm), acrylamide (AAm) with acrylic acid (A) or maleic acid (M), and N, N′-methylene bisacrylamide. Spectroscopic and thermal characterizations of SHs were performed using FTIR, TGA, and DSC. To determine the effects of SHs on swelling characteristics, swelling studies were performed in different solvents, solutions, temperatures, pHs, and ionic strengths. In addition, cycle equilibrium swelling studies were carried out at different temperatures and pHs. The temperature and pH transition points of SHs are calculated using a sigmoidal equation. The pH transition points were calculated as 5.2 and 4.2 for SH-M and SH-A, respectively. The NIPAAm/AAm hydrogel exhibits a critical solution temperature (LCST) of 28.35 °C, while the SH-A and SH-M hydrogels exhibit the LCST of 34.215 °C and 28.798 °C, respectively, and the LCST of SH-A is close to the body. temperature. Commercial (CHSA) and blood human serum albumin (BHSA) were used to find the adsorption properties of biopolymers on SHs. SH-M was the most efficient SH, adsorbing 49% of CHSA while absorbing 16% of BHSA. In conclusion, the sigmoidal equation or Gaussian approach can be a useful tool for chemists, chemical engineers, polymer and plastics scientists to find the transition points of smart hydrogels.

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Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

Yang,

Zhou,

et al. 2024

Exploration

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Because therapeutic cancer vaccines can, in theory, eliminate tumor cells specifically with relatively low toxicity, they have long been considered for application in repressing cancer progression. Traditional cancer vaccines containing a single or a few discrete tumor epitopes have failed in the clinic, possibly due to challenges in epitope selection, target downregulation, cancer cell heterogeneity, tumor microenvironment immunosuppression, or a lack of vaccine immunogenicity. Whole cancer cell or cancer membrane vaccines, which provide a rich source of antigens, are emerging as viable alternatives. Autologous and allogenic cellular cancer vaccines have been evaluated as clinical treatments. Tumor cell membranes (TCMs) are an intriguing antigen source, as they provide membrane‐accessible targets and, at the same time, serve as integrated carriers of vaccine adjuvants and other therapeutic agents. This review provides a summary of the properties and technologies for TCM cancer vaccines. Characteristics, categories, mechanisms, and preparation methods are discussed, as are the demonstrable additional benefits derived from combining TCM vaccines with chemotherapy, sonodynamic therapy, phototherapy, and oncolytic viruses. Further research in chemistry, biomedicine, cancer immunology, and bioinformatics to address current drawbacks could facilitate the clinical adoption of TCM vaccines.

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Rational Design of Smart Hydrogels for Biomedical Applications

Cited by 87 publications

References 188 publications

Self-Assembly Dipeptide Hydrogel: The Structures and Properties

Self-Assembly Dipeptide Hydrogel: The Structures and Properties

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy

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