Acid suppression medications are associated with suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass in patients older than 40 years

Association of Proton Pump Inhibitor (PPI) Use with Energy Intake, Physical Activity, and Weight Gain

“…PPIs are commonly used by patients with GERD, a disease that is highly associated with obesity. Previous studies reported that PPI use was associated with impaired weight loss following bariatric surgery and weight gain in a non-surgical population [ 5 , 6 ]. Because of the paucity of data on the association of PPI use and weight gain, we aimed to investigate whether PPI use was associated with differences in energy intake, diet composition, physical activity patterns, or changes in body weight using data from the 2005–2006 NHANES.…”

“…Recently, there has been data to suggest that long-term PPI use leads to weight gain [ 5 ]. Acid suppression therapy has also been associated with suboptimal weight loss in patients who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) [ 6 ]. PPI use post-LRYGB may impair weight loss by modification of the gut microbiome and therefore influence energy extraction [ 7 ].…”

Response to Letter to the Editor Re: The Effect of PPI Use on Human Gut Microbiota and Weight Loss in Patients Undergoing Laparoscopic Roux-en-Y Gastric Bypass

“…Finally, the mean age of the cohort of Syu et al was considerably older (63.8 versus 44.3 years), and the proportion of females (29 versus 88 %) was lower compared to the patients in our study. In a separate cohort, we recently reported on the association of PPI use with suboptimal weight loss in 472 consecutive patients who underwent LRYGB, a cohort whose demographics are also significantly different than those included in the study by Syu et al [3].…”