Acidic regulation of junction channels between glomus cells in the rat carotid body. Possible role of [Ca2+]i

Abudara, Verónica; Jiang, Rugang; Eyzaguirre, C.

doi:10.1016/s0006-8993(01)02862-1

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…In addition, connexin 32 has also been identified in cultured cells (628). Natural stimuli, including hypoxia and hypercapnia, as well as several putative neurotransmitters, uncoupled most type I cells tested (5, 6) but could increase the coupling coefficient between type I cell and nerve ending. The transcript and protein levels of connexin 43 in both type I cells and petrosal ganglion cells is measurably increased by two weeks of hypobaric hypoxia (146) and, as such, may be part of the adaptation to chronic hypoxia (see later sections).…”

Section: Innervation and Communications Of The Carotid Bodymentioning

confidence: 95%

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Kumar

Prabhakar

2012

Comprehensive Physiology

465

572

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The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus-response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood-borne stimuli, including reduced glucose and immune-related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article.

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Section: Innervation and Communications Of The Carotid Bodymentioning

confidence: 95%

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Kumar

Prabhakar

2012

Comprehensive Physiology

465

572

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“…Recent studies show that some Cx hemichannels are permeable to Ca 2+ (Schalper et al, 2010; Fiori et al, 2012), and it is known that chemosensory stimuli rise glomus cells [Ca 2+ ] i (Buckler and Vaughan-Jones, 1994a,b; Abudara et al, 2001; Jiang and Eyzaguirre, 2004; Xu et al, 2006; Lowe et al, 2013). Stimulated glomus cell may excite the secretion of a non-stimulated coupled glomus cell as a calcium wave-related second messenger, like AMPc (provided the wave occurs before the aforementioned uncoupling).…”

Section: And Panx Channels In Arterial Chemoreceptionmentioning

confidence: 99%

Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals

Reyes

Cerpa

Corvalán

et al. 2014

Front. Cell. Neurosci.

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Connexins (Cxs) and Pannexins (Panx) form hemichannels at the plasma membrane of animals. Despite their low open probability under physiological conditions, these hemichannels release signaling molecules (i.e., ATP, Glutamate, PGE2) to the extracellular space, thus subserving several important physiological processes. Oxygen and CO2 sensing are fundamental to the normal functioning of vertebrate organisms. Fluctuations in blood PO2, PCO2 and pH are sensed at the carotid bifurcations of adult mammals by glomus cells of the carotid bodies. Likewise, changes in pH and/or PCO2 of cerebrospinal fluid are sensed by central chemoreceptors, a group of specialized neurones distributed in the ventrolateral medulla (VLM), raphe nuclei, and some other brainstem areas. After many years of research, the molecular mechanisms involved in chemosensing process are not completely understood. This manuscript will review data regarding relationships between chemosensitive cells and the expression of channels formed by Cxs and Panx, with special emphasis on hemichannels.

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“…We have found clear evidence for electric connections between glomus cells, GC/GC coupling (Monti-Bloch et al, 1993;Abudara, 1995, 1999), with coupling channels behaving similarly to those in other tissues (Abudara et al, 2001(Abudara et al, , 2002. Furthermore, injections of dye (Procion Blue, Lucifer Yellow) into one glomus cell spreads to other coupled cells (Baron and Eyzaguirre, 1977;Eyzaguirre et al, 2003).…”

Section: Endingsmentioning

confidence: 90%

Chemical and electric transmission in the carotid body chemoreceptor complex

Eyzaguirre

2005

Biol. Res.

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Carotid body chemoreceptors are complex secondary receptors. There are chemical and electric connections between glomus cells (GC/GC) and between glomus cells and carotid nerve endings (GC/NE). Chemical secretion of glomus cells is accompanied by GC/GC uncoupling. Chemical GC/NE transmission is facilitated by concomitant electric coupling. Chronic hypoxia reduces GC/GC coupling but increases G/NE coupling. Therefore, carotid body chemoreceptors use chemical and electric transmission mechanisms to trigger and change the sensory discharge in the carotid nerve.

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Acidic regulation of junction channels between glomus cells in the rat carotid body. Possible role of [Ca2+]i

Cited by 13 publications

References 32 publications

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals

Chemical and electric transmission in the carotid body chemoreceptor complex

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