Acinar cell carcinoma of the pancreas -Clinical analysis of 115 patients from pancreatic cancer registry of Japan Pancreas Society-

Kitagami, Hidehiko; Kondo, Satoshi; Hirano, Satoshi; Kawakami, Hiroshi; Egawa, Shinichi; Tanaka, Masao

doi:10.2958/suizo.22.718

Cited by 59 publications

(103 citation statements)

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“…Surgery should be The survival curves suggest a more aggressive cancer than pancreatic endocrine neoplasms but one that is less aggressive than ductal adenocarcinoma of the pancreas. Kitagami et al [20] 115 (2007) A possibility of surgical resection should be pursued to achieve better prognosis. If ACC is unresectable or recurrent, chemotherapy is likely to prove useful.…”

Section: Resultsmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

Chaudhary

2014

Indian J Surg

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Pancreatic acinar cell carcinoma is a rare tumour, accounting for only about 1 % of all pancreatic tumours. The long-term survival for patients with acinar cell carcinoma is significantly better than the long-term survival of patients with pancreatic adenocarcinoma. As no large series of patients with acinar cell carcinomas exist, our understanding of this disease comes mainly from small case series and case reports. Aggressive surgical resection with negative margins is associated with long-term survival in these more favourable pancreatic cancers. There are no clear treatment guidelines for patients in whom complete surgical resection with curative intent is not possible. Acinar cell carcinomas are chemoresponsive to agents that have activity against pancreatic adenocarcinomas and colorectal carcinomas because of the shared genetic alterations between these cancers. The role of neoadjuvant or adjuvant chemoradiotherapy remains unproven. The aim of this article is to present current knowledge on acinar cell carcinoma and comprehensive review of available literature.

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Section: Resultsmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

Chaudhary

2014

Indian J Surg

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“…Another significant argument against a metastasis from a pancreatic primary is the fact that there was only one hepatic mass and not, as it is usually seen in metastatic pancreatic acinar cell carcinoma, multiple liver tumors. [1][2][3]5 Moreover, metastatic pancreatic acinar cell carcinomas are usually large and about 50% of the patients with pancreatic acinar cell carcinoma have at the time of initial diagnosis evidence of metastatic disease, outside the liver. [1][2][3]5 Regarding the histogenesis of hepatic acinar cell carcinoma, there is no ready answer as yet.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3]5 Moreover, metastatic pancreatic acinar cell carcinomas are usually large and about 50% of the patients with pancreatic acinar cell carcinoma have at the time of initial diagnosis evidence of metastatic disease, outside the liver. [1][2][3]5 Regarding the histogenesis of hepatic acinar cell carcinoma, there is no ready answer as yet. Previous reports of extra-pancreatic acinar cell carcinomas suggested an origin from heterotopic or metaplastic pancreatic tissue, and this could be demonstrated in some cases.…”

Section: Discussionmentioning

confidence: 99%

“…1 Approximately half of the patients have evidence of metastatic disease at the time of diagnosis, underlining their aggressive behavior. 2 Besides their characteristic histological features, acinar cell carcinomas are defined on the basis of their immunohistochemical staining for pancreatic enzymes, notably trypsin. [3][4][5] There are few case reports on neoplasms with pancreatic acinar cell differentiation that occurred outside the pancreas, particularly in the gastrointestinal tract.…”

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confidence: 99%

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Pancreatic-type acinar cell carcinoma of the liver: a clinicopathologic study of four patients

et al. 2011

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Acinar cell carcinoma of pancreatic type rarely occurs at extra-pancreatic sites. We report four primary liver tumors with features of pancreatic acinar cell carcinoma. The patients were two males and two females with a mean age of 65 years (range, 49-72 years). They had upper abdominal pain, weight loss and/or an incidentally discovered liver mass. None had evidence of a primary pancreatic tumor. Grossly, the tumors were large (mean size, 12 cm), well circumscribed and showed a lobulated cut surface. Histologically, they showed a predominantly microacinar pattern, with occasional trabecular, solid and microcystic areas. Cellular atypia and mitotic activity varied within the same tumor and from tumor to tumor. Immunohistochemically, the tumor cells were positive for cytokeratin 18 and at least one acinar cell marker (ie, trypsin, amylase or lipase), but were negative for cytokeratins 7, 19 and 20, HepPar-1, AFP, CD10, carcinoembryonic antigen, CD56, Islet-1 and CDX2. Two tumors stained focally for synaptophysin and chromogranin A. Adjacent liver parenchyma displayed no evidence of cirrhosis. During a mean follow-up of 22 months (range, 3-38 months) no metastases occurred, but one patient developed local recurrence. Our study demonstrates that acinar cell carcinoma of pancreatic type may also originate from the liver and can be readily distinguished from other primary liver neoplasms by its distinct histological and immunohistochemical features. Because our cases were observed within a rather short period, it is likely that this tumor type is so far underrecognized and has been mistaken as a variant of hepatocellular carcinoma, cholangiocarcinoma or any other liver tumor.

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“…ACC predominantly affects males with a mean age of 56 to 64 years at presentation [3]. ACC usually presents with abdominal pain, weight loss and less commonly jaundice in 12-20% of cases [4,5]. A rare para-neoplastic syndrome called lipase hyper-secretion syndrome (LHS) was reported in association with ACC.…”

Section: Introductionmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas with Postoperative Lipase Hyper-Secretion Syndrome: Case Report and Review of the Literature

2017

ARC Journal of Clinical Case Reports

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Acinar cell carcinoma of the pancreas -Clinical analysis of 115 patients from pancreatic cancer registry of Japan Pancreas Society-

Cited by 59 publications

References 1 publication

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update

Pancreatic-type acinar cell carcinoma of the liver: a clinicopathologic study of four patients

Acinar Cell Carcinoma of the Pancreas with Postoperative Lipase Hyper-Secretion Syndrome: Case Report and Review of the Literature

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