Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Conlon, Niamh; Sadri, Navid; Corben, Adriana D.; Tan, Lee K.

doi:10.1016/j.humpath.2015.12.014

Cited by 45 publications

(58 citation statements)

References 30 publications

(55 reference statements)

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“…Although the last WHO classification states that some histologic, immunohistochemical and ultrastructural differences favor the distinction of microglandular adenosis/atypical microglandular adenosis and acinic cell carcinoma (11), our data showing diffuse expression of lysozyme in microglandular adenosis/atypical microglandular adenosis cells calls into question the practice of differentiating these two entities on the basis of the expression of serous differentiation markers. Moreover, akin to microglandular adenoses and atypical microglandular adenoses (5), acinic cell carcinomas may also display circumferential expression of antibodies targeting basement membrane such as laminin (13). Therefore, to establish a diagnosis of pure acinic cell carcinoma of microglandular growth pattern, it might be prudent to use criteria similar to those used to diagnose invasive carcinoma in microglandular adenoses/atypical microglandular adenoses, such as the presence of stromal desmoplasia and/or confluent glands.…”

Section: Discussionmentioning

confidence: 99%

“…Acinic cell carcinoma is a rare special histologic type of breast cancer of low-grade and indolent behavior (11), which, akin to microglandular adenoses/atypical microglandular adenoses, may progress to high-grade triple-negative breast cancer (12, 13). Indeed, metastatic potential may be limited to those cases mixed with a high-grade/non-acinic cell component (11).…”

Section: Introductionmentioning

confidence: 99%

“…Despite conceptual differences, microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas display histologic and immunohistochemical similarities (1, 11, 13, 15). Morphologically, both entities typically are characterized by an infiltrative proliferation of small glands lined by low-grade cuboidal to flattened cells lacking a myoepithelial cell layer (1, 11).…”

Section: Introductionmentioning

confidence: 99%

“…Morphologically, both entities typically are characterized by an infiltrative proliferation of small glands lined by low-grade cuboidal to flattened cells lacking a myoepithelial cell layer (1, 11). Acinic cell carcinomas may however display a distinct architecture such as the hypernephroid clear cell pattern (12), and may show intra-tumor heterogeneity with well-differentiated tubular and less-differentiated solid areas (13). Immunophenotypically, microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas are characterized by strong expression of S100 protein (4–7, 9, 16) and most are of triple-negative immunophenotype (4, 6, 7, 9, 12, 13, 16).…”

Section: Introductionmentioning

confidence: 99%

“…Acinic cell carcinomas may however display a distinct architecture such as the hypernephroid clear cell pattern (12), and may show intra-tumor heterogeneity with well-differentiated tubular and less-differentiated solid areas (13). Immunophenotypically, microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas are characterized by strong expression of S100 protein (4–7, 9, 16) and most are of triple-negative immunophenotype (4, 6, 7, 9, 12, 13, 16). Differential diagnosis of microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas can be challenging (15, 16) and often relies on the identification of diffuse serous differentiation in acinic cell carcinomas (11, 16).…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

et al. 2017

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Acinic cell carcinoma is an indolent form of invasive breast cancer, whereas microglandular adenosis has been shown to be a neoplastic proliferation. Both entities display a triple-negative phenotype, and may give rise to and display somatic genomic alterations typical of high-grade triple-negative breast cancers. Here we report on a comparison of previously published data on eight carcinoma-associated microglandular adenosis and eight acinic cell carcinomas subjected to targeted massively parallel sequencing targeting all exons of 236 genes recurrently mutated in breast cancer and/or DNA repair-related. Somatic mutations, insertions/deletions and copy number alterations were detected using state-of-the-art bioinformatic algorithms. All cases were of triple-negative phenotype. A median of 4.5 (1–13) and 4.0 (1–7) non-synonymous somatic mutations per carcinoma-associated microglandular adenosis and acinic cell carcinoma were identified, respectively. TP53 was the sole highly recurrently mutated gene (75% in microglandular adenosis versus 88% in acinic cell carcinomas), and TP53 mutations were consistently coupled with loss of heterozygosity of the wild-type allele. Additional somatic mutations shared by both groups included those in BRCA1, PIK3CA and INPP4B. Recurrent (n=2) somatic mutations restricted to microglandular adenosis or acinic cell carcinomas included those affecting PTEN and MED12, or ERBB4, respectively. No significant differences in the repertoire of somatic mutations were detected between microglandular adenosis and acinic cell carcinomas, and between this group of lesions and 77 triple-negative carcinomas from The Cancer Genome Atlas. Microglandular adenosis and acinic cell carcinomas, however, were genetically distinct from estrogen receptor-positive and/or HER2-positive breast cancers from The Cancer Genome Atlas. Our findings support the contention that microglandular adenosis and acinic cell carcinoma are part of the same spectrum of lesions harboring frequent TP53 somatic mutations, and likely represent low-grade forms of triple-negative disease with no/minimal metastatic potential, of which a subset has the potential to progress to high-grade triple-negative breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

et al. 2017

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Suggestions for creating the International Scientific Foundation of Saliva Diagnosis (ISFSD): New research strategies, development, and technologies

Mediouni¹,

Kaczor‐Urbanowicz

Madiouni

2019

Oral Science International

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Saliva is an emerging biofluid for personalized/precision medicine application. As it has recently become a major tool for biological research and biomarker discovery, it is of vital importance to develop and optimize the diagnostics standards to decipher the omics constituents in saliva in order to achieve better oral and systemic health. Although current variations in saliva sampling, study designs, and developmental methods of salivary biomarkers prevent direct comparisons of the data obtained from different studies, the lack of standardization and unification of the processing procedures undermines saliva's diagnostic potential. Thus, it motivated us to propose the idea of creating an International Scientific Foundation of Salivary Diagnosis (ISFSD) that could encourage collaborative efforts to establish international guidelines and standardized protocols for saliva collection and laboratorial processing as well as clinical diagnostics. The ISFSD can accelerate the validation of biomarkers in larger groups of patients, their regulatory approval, and implementation of saliva diagnostics into a real clinical practice. It will also result in identification of practical and achievable priorities, and will present policy initiatives critical to the implementation of oral health improvement programs. The establishment of ISFSD will be of great interest and influence in the fields of oral health, dentistry, and medicine.

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Invasive Carcinoma

Tan¹,

Şahin²

2017

Atlas of Differential Diagnosis in Breast Pathology

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Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Cited by 45 publications

References 30 publications

Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

Suggestions for creating the International Scientific Foundation of Saliva Diagnosis (ISFSD): New research strategies, development, and technologies

Invasive Carcinoma

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