Acinic Cell Carcinoma of Parotid Gland: Report of Three Cases and Literature Review

Oliveira, Lucinei Roberto; Soave, Danilo Figueiredo; Costa, João Paulo Oliveira da; Ribeiro‐Silva, Alfredo

doi:10.1016/s1646-2890(10)70079-0

Cited by 6 publications

(7 citation statements)

References 37 publications

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“…According to the AJCC [22], 80% of cases were in stage I while in 20% of cases were distributed among stage II and IV respectively. As regards these clinical findings, there was no unusual presentation of ACC cases in the presenting study and all these symptoms are in agreement with many previous studies [5,23,24]. There was no significant correlation obtained between intensity of staining of all markers and staging of tumor.…”

supporting

confidence: 92%

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Atta¹,

Qahtani²

2015

J Histol Histopathol

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Introduction: Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). α-amylase was described to be specific for normal acinar cell but its affinity to malignant counterpart is being contentious. Recently discovered marker anoctamin (DOG1) specific for diagnosis of GISTs has been reported for its efficacy to stain the malignant acinar cells and so, it is being of value in ACC diagnosis. On the other hand, negativity of acinar cells to basal cell marker as p63 will give more pronouncement to ACC diagnosis. Objectives: The study were designed to scrutinize the expression of recent marker DOG1 versus α-amylase in ACC diagnosis. Also to correlate between clinical, radiological, histopathological and immunohistochemical findings in ACC cases. Material and methods: Fourteen cases of ACC were obtained and stained immunohistochemically for DOG1, α-amylase and p63. Clinical data as well as radiological findings were obtained from the patients' file to form correlation with immunostaining results. Results: All ACCs (100%) revealed positivity toward DOG1 staining, 6 (44%) cases out of 14 showed α-amylase positivity, and 1 case (7%) showed focal positivity for p63. No significant correlation was found between clinical, radiological and immunostaining results. Significant correlation was obtained between results of DOG1 and α-amylase with p-value=0.034, also significant correlation was obtained between DOG1 and p63 with p-value=0.02. On the other hand, no significant correlation was obtained between results of both α-amylase and p63 with p-value=0.546. Conclusion: DOG1 has a higher efficacy in the diagnosis of ACC than α-amylase and must be used especially for cases with some conflicts as poor tissue sampling or suspicious cases with other carcinomas especially with carcinomas of clear cell features or having a vacuolated cytoplasm.

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supporting

confidence: 92%

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Atta¹,

Qahtani²

2015

J Histol Histopathol

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“…Surgery is the treatment of choice for central acinic cell carcinoma and postoperative radiotherapy may be useful for recurrent, undifferentiated cases of acinic cell carcinoma, positive margins and advanced tumours with cervical node spread the present case was treated surgically. 7…”

Section: Discussionmentioning

confidence: 99%

Acinic cell carcinoma of ascending ramus mandible: a rare case report

Munjal

Rishi

Tuli

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Acini cell carcinoma are low grade tumors of the salivary glands with a rare occurrence in the axial or appendicular skeleton. The parotid, submandibular and the minor salivary glands are sites of involvement in that order. Painless swelling is the usual presentation with a lytic appearance on radiology and imaging, CT or MRI, FNAC can to some extent differentiate between a benign or malignant lesion thereby dictating the likely extent of excision. On histopathological examination of resected specimens, acinic cell carcinoma shows tumor cells arranged as papillary clusters, acinar pattern and dispersed population with individual tumor cells displaying moderate nuclear pleomorphism, anisonucleosis, round nuclei and moderate amount of ill-defined granular cytoplasm. A unique intraosseous presentation of acinic cell carcinoma, in an elderly male, necessitated a segmental partial mandibulectomy and a comprehensive neck dissection. The tumour area was widely excised from the second premolar region to the coronoid process, and radical neck dissection was performed.

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“…They are composed of diverse cell types and include acinic cells, vacuolated cells, intercalated cells, nonspecific glandular cells and clear cells. Large lobules or nests of tumor cells with little intervening stroma are characteristics [ 9 , 10 , 11 ]. The histologic grading of acinic cell carcinomas is controversial, and unlike clinical staging, histomorphology has not proven to be reliable in predicting its behavior [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The death rate due to ACCs varies from 1.3 to 26%. The recurrence rate for these tumors ranges from 30 to 50%, and when the deep lobe of the parotid gland is reached, local recurrences are higher than in superficial tumors (72 and 18%, respectively) [ 11 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of the Literature

et al. 2015

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We report on a patient who was referred to the ENT service following an incidental finding on an MRI scan of the brain. It revealed a mass in the right parapharyngeal space, and additional imaging confirmed the presence of a solid cystic expansive mass with moderate enhancement following contrast media injection. The patient was treated with a total parotidectomy followed by radiotherapy. Currently, the patient is disease-free without any complications.

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Acinic Cell Carcinoma of Parotid Gland: Report of Three Cases and Literature Review

Cited by 6 publications

References 37 publications

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Acinic cell carcinoma of ascending ramus mandible: a rare case report

Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of the Literature

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