Acinic cell carcinoma of the posterior buccal mucosa

Babu, Sharlene Sara; Sunil, S; Prathap, Akhilesh; Mathew, Anju

doi:10.4103/jcrt.jcrt_399_18

Cited by 4 publications

(4 citation statements)

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“…AcCC is the third most common epithelial malignancy of the salivary glands in adults, following mucoepidermoid carcinoma and adenoid cystic carcinoma. Its diagnosis is on the basis of the characteristic histomorphologic appearance in low-grade cases, but it is challenging in cases with high-grade transformation "zymogen granule" [4], [7]. At 2019, Haller et al study discovered a novel genomic rearrangement (t [4; 9] [q13; q31]), leading to the upregulation of nuclear receptor subfamily 4 Group A member 3 (NR4A3) at 9q31 through molecular analysis of several AcCCs [20].…”

Section: Discussionmentioning

confidence: 99%

“…Acinic cell carcinoma (AcCC) is a lowgrade malignant salivary gland neoplasm that comprises approximately 17% of primary salivary gland malignancies or about 6% of all salivary gland neoplasms. AcCC is the second most common epithelial malignancy in the pediatric age group following mucoepidermoid carcinoma [4]. AcCC histologic features are often characteristic, with serous acinar cells containing basophilic zymogen granules mixed with intercalated duct-type cells with cytoplasm variably clear, vacuolated, or oncocytoid.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Algharyani

Maghrabi²,

Ezzat³

et al. 2022

Open Access Maced J Med Sci

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Salivary gland carcinomas are diagnostically challenging lesions in heterogeneous groups. However, recently described genomic alterations may be helpful and have future therapeutic implications. The molecular investigation is becoming useful tool to help diagnosis and provide prognostic information. Diagnosis of acinic cell carcinoma (AcCC) is challenging due to its rarity and similarity with other SGCs or normal acinar cells. Herein, the diagnostic performance of transcription factor nuclear receptor subfamily 4 group A member3 (NR4A3) was analysed immunohistochemically. This study was done on 68 cases of SCCs, including 32 of AcCC, 14 of adenoid cystic carcinoma (AdCC), 8 of mucoepidermoid carcinoma (MEC), 7 of epithelial myoepithelial carcinoma (EMC), 4 of salivary duct carcinoma (SDC), and only one case from each of carcinoma ex pleomorphic adenoma (CXPA), polymorphous adenocarcinoma (PAC) and secretory carcinoma (SC) for detecting NR4A3. All stained samples of AcCC (100%) responded positively to the NR4A3 antibody. However, only one case of AdCC and MEC demonstrated NR4A3 immunostaining in less than 10% of cells. On the other hand, the different types of SGCs, including EMC, SDC, CXPA, PAC, and SC, revealed negative expressions. Therefore, we can conclude that NR4A3 can be used as a potential marker for AcCC rather than other SGCs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Algharyani

Maghrabi²,

Ezzat³

et al. 2022

Open Access Maced J Med Sci

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“…Diagnostic hypotheses were pleomorphic adenoma, fibroma, lipoma, in addition to malignant neoplasms such as mucoepidermoid carcinoma, adenocarcinoma, cystic adenomatoid carcinoma and acinic cell carcinoma [12]. It is worth mentioning that malignant salivary gland tumors can present clinically with an aspect of benignity and minor salivary gland tumors are predominantly malignant [13], thus complementary tests, such as fine needle aspiration or incisional biopsy, are usually used to define the diagnosis [14]. The fine needle aspiration biopsy has insufficient sensitivity and precision for the diagnosis of malignancy of pleomorphic adenoma, so the histopathological examination is more suitable for this purpose [15].…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic adenoma in buccal mucosa: A case report

Afonso¹,

Godinho²,

Godinho³

et al. 2021

Int J Case Rep Images

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Introduction: Pleomorphic adenoma is one of the most common salivary gland neoplasms, with the parotid gland being the most affected site and a lower incidence in the minor salivary glands. This article reports an unusual clinical case of pleomorphic adenoma of minor salivary gland, located in the buccal mucosa and presents its treatment.Case Report: A 65-year-old female patient with a lesion in the buccal mucosa with evolution of approximately two years was evaluated. The anatomopathological report after incisional biopsy indicated pleomorphic adenoma. The treatment performed was a complete excision of the lesion under local anesthesia. The specimen, measuring 20.51 mm, was sent for anatomopathological examination, whose report confirmed the previous diagnosis. Conclusion:The complete excision of pleomorphic adenoma of minor salivary gland in the buccal mucosa under local anesthesia allowed the patient to heal and prevented a possible malignant transformation, with little associated morbidity.

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“…It was initially proposed as an independent type of salivary gland tumor by Foote and Frazell in 1953 [ 2 ]. In addition to salivary gland, AciCC also has been observed in lung, breast and other organs [ 3 , 4 ]. Among them, primary lung AciCC is even rare [ 5 ] and was firstly reported by Fechner in 1972 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Right pneumonectomy for primary large acinic cell carcinoma (AciCC) with severe mediastinal deviation: a case report and literature review

et al. 2021

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Background Primary lung acinic cell carcinoma is very rare. Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma with severe mediastinal deviation which has never been reported before. We also reviewed data and features of 20 previously reported cases of primary lung acinic cell carcinoma who underwent lobectomy. Case presentation A 27-year-old female patient presented with recurrent coughing and hemoptysis for more than 10 years came to our hospital. A chest computed tomography (CT) showed a giant space-occupying lesion in the hilum of right lung. After a thorough and detailed preoperative examination, the patient then was performed a radical right pneumonectomy with mediastinal lymph node dissection. The size of the tumor was about 8.6 × 4.5 × 4.4 cm. The pathological results demonstrated a primary acinic cell carcinoma of right lung. The immunohistochemistry of the tumor showed AE1/AE3 (+), Ki-67 (2% +), CK7 (+), Vimentin (+), CK19 (+), α1-ACT (+), AB-PAS (+), S-100 (−), TTF-1 (−). The patient was discharged less than 2 weeks after the operation. So far, the patient has been followed-up for 2 years, and no evidence of tumor recurrence or metastasis was observed. Conclusions The primary acinic cell carcinoma of lung in this case is the biggest one ever reported and also the first case treated with radical right pneumonectomy. In addition, the patient had a very rare condition of severe mediastinal deviation at the same time. After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence and metastasis after 2 years of follow-up. This case together with the reported case indicate that primary acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are relatively satisfactory.

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Acinic cell carcinoma of the posterior buccal mucosa

Cited by 4 publications

References 5 publications

Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Diagnostic Value of Nuclear Receptor Subfamily 4 Group A Member 3 in Salivary Gland Carcinomas

Pleomorphic adenoma in buccal mucosa: A case report

Right pneumonectomy for primary large acinic cell carcinoma (AciCC) with severe mediastinal deviation: a case report and literature review

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