Acl Growth With Age in Pediatric Patients: An Mri Study

Abstract

Background The incidence of anterior cruciate ligament (ACL) injury is steadily increasing in skeletally immature patients [1-7]. As a result, surgical approaches to reconstruction of the ACL without compromising the physis have been developed [6, 8, 9]. It is essential to understand how the native ACL changes with patient growth and age, in order to better understand how grafts might serve patients as they continue to grow. The purpose of this study is to characterize the morphological change over time of different ACL parameters in the pediatric and adolescent population based on serial magnetic resonance imaging (MRI). Methods After receiving Institutional Review Board approval, the patient cohort was identified retrospectively from a database of all patients who had a routine magnetic resonance imaging (MRI) of the knee between July 2005 and February 2017. Patients aged 0 to 18 years at the time of their initial MRI, who had undergone at least two serial MRI examinations of the same knee at least 4 months apart for reasons other than ACL tear were included. Patients were excluded if they had a fracture of the distal femur or proximal tibia, congenital condition that affects the knee, deformity of the femur or tibia, or if they have a pathologic process (e.g. tumor) that disrupts the anatomy of the distal femur or proximal tibia. The parameters measured included physeal status, length of the ACL, diameter of the ACL in the sagittal and coronal plane, ACL-tibial inclination angle, notch width index, the midpoint of the ACL tibial attachment, anterior to posterior dimension of the tibia, and tibial epiphyseal height. A Pearson correlation coefficient was calculated to determine the strength of correlation of each parameter relative to age. Growth curves were calculated for individual parameters, which produced a predictive model for the rate of growth of the ACL at different ages. Results 162 knees in 147 patients (365 MRI studies) were identified to have had serial MRI of their knee. 50.3% of patients were female. Ages at time of MRI ranged from 1.3 to 21.7 years (average 13.5 years, SD 3.60). The Pearson correlation coefficient for each parameter showed statistically significant relationship relative to age. The ACL grows in length and diameter with age. Younger patients had more oblique, anteriorly attached ACLs compared to older patients. The growth model for ACL length shows three distinct phases of growth: patients age 1.5 to 5.75 years average 2.25 mm of growth per year; patients aged 6 to 11.5 average 1.46 mm of growth per year; growth begins to plateau at age 11.75, stopping by age 18.5 years. The growth model for ACL sagittal diameter shows an average of 0.45 mm of growth per year between 1.5 and 14.5 years old, after which growth slows until it stops at age 18.75. The ACL coronal diameter model shows an average of 0.22 mm of growth per year between 1.5 and 18.75 years old, with growth completion by age 18.75. ANCOVA was used to assess the difference in growth rates between men and women. Growth rates for ACL length, ACL diameter in the coronal plane, transcondylar width, posterior border, center, and width of ACL-tibial attachment, and anterior-to-posterior dimension of the tibia are significantly different in men and women. Namely, for all significant differences, men had faster growth rates than women. Conclusions/Significance In the skeletally immature patient, the ACL grows in length and diameter in a predictable fashion until age 18. This model aids clinicians in predicting normal ACL parameters for reconstruction procedures in the skeletally immature patient. It may have important implications for ACL reconstruction in very young patients. [Table: see text][Table: see text][Figure: see text][Figure: see text][Figure: see text] References Mizuta, H., et al., The conservative treatment of complete tears of the anterior cruciate ligament in skeletally immature patients. J Bone Joint Surg Br, 1995. 77(6): p. 890-4. Angel, K.R. and D.J. Hall, Anterior cruciate ligament injury in children and adolescents. Arthroscopy, 1989. 5(3): p. 197-200. Lawrence, J.T., N. Argawal, and T.J. Ganley, Degeneration of the knee joint in skeletally immature patients with a diagnosis of an anterior cruciate ligament tear: is there harm in delay of treatment? Am J Sports Med, 2011. 39(12): p. 2582-7. Dumont, G.D., et al., Meniscal and chondral injuries associated with pediatric anterior cruciate ligament tears: relationship of treatment time and patient-specific factors. Am J Sports Med, 2012. 40(9): p. 2128-33. Newman, J.T., et al., Factors predictive of concomitant injuries among children and adolescents undergoing anterior cruciate ligament surgery. Am J Sports Med, 2015. 43(2): p. 282-8. Kocher, M.S., S. Garg, and L.J. Micheli, Physeal sparing reconstruction of the anterior cruciate ligament in skeletally immature prepubescent children and adolescents. J Bone Joint Surg Am, 2005. 87(11): p. 2371-9. Cruz, A.I., Jr., et al., All-Epiphyseal ACL Reconstruction in Children: Review of Safety and Early Complications. J Pediatr Orthop, 2017. 37(3): p. 204-209.

Magnetic resonance imaging assessment of the cruciate ligament thickness among apparently healthy Nigerians

“…However, the posterior cruciate ligaments thickness increased with age having a greater thickness at old age than at ayoung age. This finding is consistence with the findings of recent studies [9,10]. Infact, Iriuchishimaet al, [9] reported that 'the anterior cruciate ligament areas on the sagittal plane were significantly larger in the younger age group when compared to the elderly age group' similar to the findings of the present study.…”

“…The posterior cruciate ligament showed marked growth especially at the femoral end compared to the anterior cruciate ligaments. This is consistent with a related study that reported that ACL grows in thickness until the age of 18years [10]. The earlier study revealed that ACL thickness showed an average of 0.22 mm of growth per year between 1.5 and 18.75 years old with growth completed by age 18.75 years and subsequent decrease in diameter at a later age.…”

“…Pearson's correlation coefficient was used to determine the strength of the association of each parameter relative to age. This demonstrated that ACL grows in diameter and length in a predictable fashion until age of 18 years [10]. These studies were done outside the shores of Nigeria and no study till date to the best of our knowledge has measured cruciate ligament thickness using MRI and established its relationship with anthropometric variables such as age and gender in Nigeria, hence the need for this study.…”