OBJECTIVEFoot ulceration remains a major health problem for diabetic patients and has a major impact on the cost of diabetes treatment. We tested a hyperspectral imaging technology that quantifies cutaneous tissue hemoglobin oxygenation and generated anatomically relevant tissue oxygenation maps to assess the healing potential of diabetic foot ulcers (DFUs).RESEARCH DESIGN AND METHODSA prospective single-arm blinded study was completed in which 66 patients with type 1 and type 2 diabetes were enrolled and followed over a 24-week period. Clinical, medical, and diabetes histories were collected. Transcutaneous oxygen tension was measured at the ankles. Superficial tissue oxyhemoglobin (oxy) and deoxyhemoglobin (deoxy) were measured with hyperspectral imaging from intact tissue bordering the ulcer. A healing index derived from oxy and deoxy values was used to assess the potential for healing.RESULTSFifty-four patients with 73 ulcers completed the study; at 24 weeks, 54 ulcers healed while 19 ulcers did not heal. When using the healing index to predict healing, the sensitivity was 80% (43 of 54), the specificity was 74% (14 of 19), and the positive predictive value was 90% (43 of 48). The sensitivity, specificity, and positive predictive values increased to 86, 88, and 96%, respectively, when removing three false-positive osteomyelitis cases and four false-negative cases due to measurements on a callus. The results indicate that cutaneous tissue oxygenation correlates with wound healing in diabetic patients.CONCLUSIONSHyperspectral imaging of tissue oxy and deoxy may predict the healing of DFUs with high sensitivity and specificity based on information obtained from a single visit.

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Agradezco a mis chicos que siempre me tuvieron paciencia cuando no rendía como esperaba, agradezco a mis padres que nunca me presionaron por llevar el ritmo con el que me sentía cómodo, agradezco a la universidad por permitirme convertirme en profesional dentro de ella y agradezco a cada persona que de alguna manera llenó de obstáculos mi proceso académico porque en su superación encontré mi realización. Agradezco a mi director de tesis por su paciencia y agradezco a internet, porque en él conecté con una fracción del mundo que exploraré el resto de mi vida. Agradezco a cada persona que ha aportado su conocimiento a la ciencia sin esperar nada a cambio y agradezco a Platzi, que en su cultura encontré el paso final para volverme un profesional. Agradezco a todas las personas que lean nuestro artículo porque nos están permitiendo transmitir nuestros esfuerzos, inmortalizandolos en sus memorias. El mundo es un desierto de conocimiento y podemos sonreír porque ahora hacemos parte de él, aunque solo seamos un grano de arena.-Sebastián Franco y Jhonatan Ospina, en un consenso de pensamientos.

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