Aclidinium bromide inhibits human glioma cell proliferation, migration and invasion and promotes apoptosis via the PI3K/AKT signaling pathway

Huang, Shan; Zhang, T; Zhao, Chuanxu; Qin, Jie; Peng, Qi; Li, F T; He, Xijing

doi:10.4149/neo_2018_171117n705

Cited by 4 publications

(2 citation statements)

References 26 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that Bcl-2 inhibits cell apoptosis through kinds of mechanisms [29]. Aclidinium bromide effectively induces apoptosis in U251 and U87 cells, and the antiapoptotic proteins Bcl-2, Cyclin D1, and p-AKT are decreased significantly [30]. Similarly, we found that siRNA siTM4SF1#1 and siTM4SF1#2 reduced the expression of CyclinD1 and Bcl-2, thus inducing cell cycle arrest and early apoptosis.…”

Section: Discussionsupporting

confidence: 58%

TM4SF1 promotes glioma malignancy through multiple mechanisms

Zheng¹,

Wang²,

Zhong³

et al. 2022

neo

View full text Add to dashboard Cite

Transmembrane-4 L Six Family member 1 (TM4SF1) belongs to a family of integral membrane proteins implicated in cell growth and tumor progression. Glioma is the most common and aggressive malignant brain tumor in adults. In this study, we showed that TM4SF1 was highly expressed in glioma tumor tissues and cell lines. The expression levels of TM4SF1 were negatively correlated with patients' survival rates. Silencing TM4SF1 by RNA interference inhibited the proliferation, migration, and invasion of glioma cells. Moreover, TM4SF1 silencing induced glioma cell cycle arrest and early apoptosis. In contrast, overexpression of TM4SF1 in glioma cells exhibited the opposite effects. Mechanistically, we found that loss of TM4SF1 reduced phospho-ATK, Cyclin D1, Bcl-2, and MMP-9 levels in glioma cells. Taken together, these findings provide novel insights into glioma pathogenesis and suggest that TM4SF1 may represent a novel target for glioma intervention.

show abstract

Section: Discussionsupporting

confidence: 58%

TM4SF1 promotes glioma malignancy through multiple mechanisms

Zheng¹,

Wang²,

Zhong³

et al. 2022

neo

View full text Add to dashboard Cite

show abstract

“…

With the in-depth studies on SIRT1 and other inflammatory response inhibitors in recent years, early monitoring and intervention on inflammatory response are expected in DN, thereby decreasing proteinuria (Huang et al, 2018). SIRT1 is a NAD + -dependent histone deacetylase, which is mainly distributed in mesangial cells, podocytes, renal tubular epithelial cells and renal interstitial cells in the kidney (Chen et al, 2017).

…”

mentioning

confidence: 99%

Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway

Wang

Zhang

2022

Food Sci. Technol

View full text Add to dashboard Cite

IL-9 promotes methicillin-resistant Staphylococcus aureus pneumonia by regulating the polarization and phagocytosis of macrophages

Xu,

Tian,

et al. 2023

Infect Immun

View full text Add to dashboard Cite

In this study, we examined the effect of Il9 deletion on macrophages in methicillin-resistant Staphylococcus aureus (MRSA) infection. MRSA-infected mice were employed for the in vivo experiments, and RAW264.7 cells were stimulated with MRSA for the in vitro experiments. Macrophage polarization was determined by flow cytometry and quantitative real-time PCR; macrophage phagocytosis was assessed by flow cytometry and laser scanning confocal microscopy; cell apoptosis was assessed by flow cytometry and western blotting. Il9 deletion markedly elevated macrophage phagocytosis and M2 macrophages in MRSA infection, which was accompanied by elevated expression of Il10 and Arg1 and reduced expression of Inos , tumor necrosis factor-α ( Tnfα) , and Il6. Il9 deletion also inhibited macrophage apoptosis in MRSA infection, which was manifested by elevated B-cell lymphoma 2 (BCL-2) protein level and reduced protein levels of cleaved cysteine protease 3 (CASPASE-3) and BCL2-Associated X (BAX). Both the in vivo and in vitro experiments further showed the activation of phosphoinositide 3-kinase (PI3K)/AKT (also known as protein kinase B, PKB) signaling pathway in MRSA infection and that the regulation of Il9 expression may be dependent on Toll-like receptor (TLR) 2/PI3K pathway. The above results showed that Il9 deletion exhibited a protective role against MRSA infection by promoting M2 polarization and phagocytosis of macrophages and the regulation of Il9 partly owing to the activation of TLR2/PI3K pathway, proposing a novel therapeutic strategy for MRSA-infected pneumonia.

show abstract

Aclidinium bromide inhibits human glioma cell proliferation, migration and invasion and promotes apoptosis via the PI3K/AKT signaling pathway

Cited by 4 publications

References 26 publications

TM4SF1 promotes glioma malignancy through multiple mechanisms

TM4SF1 promotes glioma malignancy through multiple mechanisms

Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway

IL-9 promotes methicillin-resistant Staphylococcus aureus pneumonia by regulating the polarization and phagocytosis of macrophages

Contact Info

Product

Resources

About