Acne and antibiotics: a look back

Weiner, David M.; James, William D.

doi:10.1111/ijd.15550

Cited by 2 publications

(1 citation statement)

References 76 publications

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“…Currently, antibiotics for the treatment of AV mainly include erythromycin, tetracycline and clindamycin . However, these antibiotics can cause irritation and drying of the skin, immunological hypersensitivity, organ damage and photosensitivity (Weiner DM et al, 2021). In addition, long-term antibiotic treatment can lead to bacterial resistance, rendering some medications ineffective against AV (Karadag AS et al, 2021;Aslan Kayiran M et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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The aim of this study was to evaluate the antibacterial activity and underlying mechanism of ethanol extracts of Meconopsis quintuplinervia Regel (EMQ) against the acne-causing bacteria Propionibacterium acnes and Staphylococcus aureus. The study results indicated that EMQ was an effective antibacterial agent against P. acnes and S. aureus, with a DIZ of 14.5 and 13.2mm, MIC of 12.5 and 12.5mg/mL and MBC of 100 and 50mg/mL, respectively. EMQ induced morphological changes to bacterial cells, as determined by electron microscopy. Leakage of alkaline phosphatase and nucleic acids confirmed that EMQ compromised the membrane integrity of bacterial cells. Furthermore, protein analysis revealed that EMQ hindered total protein expression and lowered adenosine triphosphatase activity, while crystal violet staining revealed suppressed biofilm production. Bacterial adhesion analysis demonstrated that EMQ lowered the adhesive capacity of bacterial cells. The main chemical components of EMQ, identified by LC-MS, seem to have important roles in the antimicrobial effects against P. acnes and S. aureus, suggesting EMQ is a promising therapeutic for acne treatment.

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Section: Introductionmentioning

confidence: 99%