Acorus Linnaeus: a review of traditional uses, phytochemistry and neuropharmacology

Xu, Feng; Yu, Yang; Qin, Da-Peng; Gao, Hao; Yao, Xin‐Sheng

doi:10.1039/c4ra12049c

Cited by 30 publications

(20 citation statements)

References 64 publications

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“…For example, b-asarone (1-propenyl-2,4,5-trimethoxy-benzene), isolated from plants such as Acorus Linnaeus,e xhibitsawide spectrum of biological activities by its epoxidation to form (Z)-asarone epoxides. [17,18] trans-Anethole (1-propenyl-4-methoxy-benzene), which is found in the essential oils of severalp lants including fennel and Chinese star aniseed, has potent pharmacological effect by its metabolism to the epoxides. [18,19] Therefore, we studied the use of the T213M mutant and the T213Ym utant of P450 119p eroxygenase to catalyzet he asymmetric epoxidation of the cis-b-methylstyrenes with substituentso nt he benzene ring.…”

Section: Resultsmentioning

confidence: 99%

“…For example, certain epoxidation products of cis-b-methylstyrenes such as b-asarone and cis-anethole are versatile precursors for the synthesis of pharmaceutically and biologically active molecules. [17][18][19] Although extensivee xperimental studies on the epoxidation of styrene and its derivatives by using the P450 monooxygenases have been reported, [1,3] and computational data is available on olefin epoxidation by using P450 enzymes, [2,20] highlye nantioselective epoxidationo fs ome specific substrates such as cis-b-methylstyrene remains as ignificant challengei nt he field of P450 catalysis. For example,O ritiz de Montellano reported that the wild-type P450cam monooxygenase catalyzest he epoxidationo fs tyrene and b-methylstyrene, but only 78 % ee was observed for the asymmetrice poxidation of cis-b-methylstyrene.…”

Section: Introductionmentioning

confidence: 99%

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Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis‐β‐Methylstyrenes

Zhang

Liu

Huang

et al. 2016

Chemistry A European J

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P450 119 peroxygenase and its site-directed mutants are discovered to catalyze the enantioselective epoxidation of methyl-substituted styrenes. Two new site-directed P450 119 mutants, namely T213Y and T213M, which were designed to improve the enantioselectivity and activity for the epoxidation of styrene and its methyl substituted derivatives, were studied. The T213M mutant is found to be the first engineered P450 peroxygenase that shows highly enantioselective epoxidation of cis-β-methylstyrenes, with up to 91 % ee. Molecular modeling studies provide insights into the different catalytic activity of the T213M mutant and the T213Y mutant in the epoxidation of cis-β-methylstyrene. The results of the calculations also contribute to a better understanding of the substrate specificity and configuration control for the regio- and stereoselective peroxygenation catalyzed by the T213M mutant.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis‐β‐Methylstyrenes

Zhang

Liu

Huang

et al. 2016

Chemistry A European J

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“…Acorus calamus with their local name Jeringau or Dlingo (Javanese), are perennial herb with diverse distribution around the world. This herb has α-and β-asarone, phenylpropanoids, lignans, terpenoids, alkaloids, flavonoids, quinones, sterols, and many derivatives mostly in their rhizomes [26]. These phytochemical substances have the ability as antimicrobial and anticancer [27], in vitro tested antidiabetic [28], antioxidant [29], larvicidal [30], insecticides [31] also as antivirals for dengue [32].…”

Section: Ethnomedicinal Research Across Indonesiamentioning

confidence: 99%

Upgrading Indonesian Local Ethnomedicinal Knowledge with Molecular Phylogenetics

Brazia¹,

Adi²,

Kaho³

et al. 2020

Proceedings of the 5th International Conference on Food, Agriculture and Natural Resources (FANRes 2019)

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With at least 200 ethnic groups and 30.000 medicinal plants used in Jamu formulations, Indonesia is one of the largest natural drug dispensaries in the world. Ethnomedicine-directed bioprospecting has been used to accelerate drug discovery. Little is known about the coverage of ethnomedicinal studies in Indonesia. The quest to obtain drugs from plants also remains elusive. Nature-derived approved drugs worldwide have come mostly from drug-productive families that tend to be clustered in the phylogenetic tree, thus these families should be the basis of bioprospecting focus. We presented a review of ethnomedicinal research conducted across Indonesia and recommend strategic approaches to accelerate the translation of traditional knowledge into the clinic. We identified several plant species commonly used with similar or different purposes within different places, empirical pharmacological studies, regions that are understudied, and comparison with plants whose metabolites have been used for the development of approved medicine worldwide. Combination of ethnomedicinal knowledge with molecular phylogenetics,-omics, Bioactivity-guided bioprospecting, DNA barcoding, and Global Biodiversity Information Facility (GBIF) software will enable more efficient and environmentally friendly drug discovery process as well as commercial production. Altogether, this proposed method will be a game-changer in the exploration of the largely untapped chemical diversity of Indonesian flora.

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“…rumphianus , the rhizomes of A . tatarinowii , A. gramineus , and A. calamus have been widely used as herbal medicine, particularly for the treatment of central nervous system (CNS) diseases in Asian countries (Lee et al ., ; Rajput et al ., ; Feng et al ., ; Liu et al ., ). To ensure the safety and well‐being of the patients, the correct species of Acorus being used medicinally should be clarified.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

Lam

Huang

Yao

et al. 2017

Phytotherapy Research

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Acori Tatarinowii Rhizoma (ATR), the rhizome of Acorus tatarinowii Schott, is a common traditional Chinese medicine being used clinically for mental disorder. However, other Acorus species herbs are all having the same Chinese name 'Chang Pu', making the confusion in herbal market. Acori Graminei Rhizoma (AGR) and Acori Calami Rhizoma (ACR) are common adulterants of ATR. Here, we aim to provide a comparative analysis between ATR, AGR, and ACR in potentiating neuronal differentiation. Volatile oil, derived from Acorus species, was applied onto cultured PC12 cells, and various parameters were determined: (i) transcriptional activation of neurofilament promoters was determined by the promoter-driven luciferase activity assay; (ii) the neurite outgrowth of PC12 cells was captured and measured; and (iii) the neurofilament expression and its underlying mechanism were analyzed by western blotting. The co-treatment of ATR, AGR, or ACR volatile oil with low concentration of nerve growth factor (NGF) could potentiate the NGF-induced neuronal differentiation in cultured PC12 cells. In addition, application of protein kinase A inhibitor H89 in cultures blocked the induction of neurofilament. Among these three Acorus species, ATR volatile oil showed the highest NGF-induced induction in neurite outgrowth and neurofilament expression, as compared with that of AGR and ACR. Copyright © 2017 John Wiley & Sons, Ltd.

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Acorus Linnaeus: a review of traditional uses, phytochemistry and neuropharmacology

Abstract: Acorus Linnaeus is a herb used in many ancient medicinal systems. Phytochemical and neuropharmacological studies have revealed that many beneficial compounds possessed anticonvulsant, antiepileptic, neuroprotective, memory enhancing, and sedative properties.

Cited by 30 publications

References 64 publications

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis‐β‐Methylstyrenes

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis‐β‐Methylstyrenes

Upgrading Indonesian Local Ethnomedicinal Knowledge with Molecular Phylogenetics

Comparative Study of DifferentAcorusSpecies in Potentiating Neuronal Differentiation in Cultured PC12 Cells

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