Acoustic cavitation

Neppiras, E.A.

doi:10.1016/0370-1573(80)90115-5

Cited by 751 publications

(390 citation statements)

References 70 publications

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“…In these three "outlier" observations, subharmonic signals appeared in the recorded acoustic spectra with very little corresponding measurement of drug release. Some reports have suggested that near the onset of subharmonic activity, the subharmonic emission is intermittent [11,41] and chaotic [9]; perhaps such an intermittent phenomenon in our system produced a short burst of subharmonic activity that was captured by the spectrum analyzer, but that did not persist temporally long enough to produce measurable drug release, which requires about 200 msec [3].…”

Section: Discussionmentioning

confidence: 85%

“…Bubble cavitation dynamics produces this subharmonic emission; however, the relationship between cavitation and drug release is less apparent. As mentioned, subharmonic emission has been associated with both stable cavitation and collapse cavitation, although association with the former is observed at moderate intensities just below the onset of collapse cavitation and under carefully controlled conditions where the bubble oscillations are non-linear, but not yet chaotic [14,41,42]. There are two other signatures of collapse cavitation that we can search for to establish whether stable or collapse cavitation is associated with the subharmonic, and thus is associated with the drug release.…”

Section: Discussionmentioning

confidence: 91%

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The role of cavitation in acoustically activated drug delivery

Husseini

Rosa

Richardson

et al. 2005

Journal of Controlled Release

156

139

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Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 91%

The role of cavitation in acoustically activated drug delivery

Husseini

Rosa

Richardson

et al. 2005

Journal of Controlled Release

156

139

View full text Add to dashboard Cite

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“…•OH + NO2 → HNO3 (19) We also considered the influence of cavitaion effects on the size and shape of AuNPs formed in sonochemical synthesis. The cavitation effects are known to be affected by the physical properties of atmospheric gases such as specific heats,  = Cp/Cv, the thermal conductivity and the solubility of gas into medium [46]. The maximum temperature in the collapsing bubble, Tmax, is given by the following equation [46]:…”

Section: Resultsmentioning

confidence: 99%

Hydrogen-assisted fabrication of spherical gold nanoparticles through sonochemical reduction of tetrachloride gold(III) ions in water

Sakai

Enomoto

Sakai

et al. 2014

Ultrasonics Sonochemistry

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Section: Transient Cavitationmentioning

confidence: 99%

“…During its existence it grows to 2 or 3 times its mirial size and, upon implosion, creates ^dreme tenq)eratares and pressures within its cavity. The waU motion of a transient, gas-Med cavity is described by (Neppiras, 1980) -3 ., 1 RR+-R^=-2 0where Rmoz is the mavimnTti radius the bubble obtains just before collapse, P is the gas pressure in the bubble at its mayimiiTTi size, and Pm is the liquid pressure at transient collapse.Since the collapse of the bubble always occurs when the acoustic pressure is near its peak, Pm is similar in vahie to (PA + Po) in an infinite fluid where the bubble density is very smaD, and can be qiproximated as Po, the hydrostatic pressure, in an intense acoustic field where the bubble density is high. The ratio of the mifimnTm bubble radius to the maximum radius is given by …”

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confidence: 99%

Sonochemical reactions: mass transfer and kinetic studies of a solid-liquid system

Hagenson

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the ori^nal or copy submitted. Thus, some thesis and dissertation copies are in typewriter &ce, while others may be from aity type of computer printer.The quality of this reproductioii is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. Hgure3.14 Effect of ambient teniperature on reaction with ultrasound. 154 Afier an extensive analysis of the experimental data obtained ffom the system, it is concluded that the reaction occurs on the solid phase, and that the liquid phase reaction is negligible.Usmg several investigative techniques, the e^qiected effects of ultrasound were observed, such as the degradative effects on particle size leading to increased sur&ce area.More inq)ortantly, some novel findings of the effects of ultrasound on mass transfer parameters are reported. Results cleariy show that ultrasound enhances the intrinsic mass transfer coef&cient as well as the effective diffiisivity of an organic reactant through the ionic lattice of the product layer. In addition, ultrasound also induces siqiersaturation of Dissertation OrganizationOiapter 2 is a con:q)rehensive review of ^^t is available in the literature potaining to the use of ultrasound in organic synthesis. The latter sections of the review contain information concerning scale-iq> and design of sonochemical reactors.Chapter 3 contains the initial investigations and e>q)erimental data obtained for a model solid-liqmd reaction, the ^thesis of dibenzyl sulfide from ben;^l chloride and sodium sulfide, xising a variety of rate enhancement techniques, mchiding microphases, phase transfer catatysis 2 and ultrasound. The objective of the paper was to investigate the individual and combined effects of these rate enhancement techniques. After this work was con^leted, the research path bifiircated from, the study of phase transfer catafysis and microphases and focused solely on the use of ultrasound.Chapter 4 is a detailed investigation, including a co...

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Acoustic cavitation

Cited by 751 publications

References 70 publications

The role of cavitation in acoustically activated drug delivery

The role of cavitation in acoustically activated drug delivery

Hydrogen-assisted fabrication of spherical gold nanoparticles through sonochemical reduction of tetrachloride gold(III) ions in water

Sonochemical reactions: mass transfer and kinetic studies of a solid-liquid system

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