The role of cavitation in acoustically activated drug delivery

Husseini, Ghaleb A.; Rosa, Mario A. Díaz de la; Richardson, Eric S.; Christensen, Douglas A.; Pitt, William G.

doi:10.1016/j.jconrel.2005.06.015

Cited by 156 publications

(147 citation statements)

References 44 publications

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“…Specifically, the size of the ultrasonically-targeted tumor in the leg of rat was reduced while a non targeted tumor in the other leg was less affected [12]. More recently, we have shown that there is a strong correlation between acoustically-triggered Dox release from both stabilized and non-stabilized micelles, and the emergence of a subharmonic peak in acoustic spectra suggesting a strong role of cavitation in the release mechanism [3]. A follow up study showed that more drug release was observed from non-stabilized micelles, when compared to stabilized micelles [13].…”

Section: Introductionmentioning

confidence: 80%

“…The same drug concentration was also prepared in PBS. Additional details have been published earlier [3,4].…”

Section: Drug Encapsulation In Pluronic Micellesmentioning

confidence: 99%

“…Details were described previously [3,4]. Briefly, an argon-ion laser beam at 488 nm was directed to either a cuvette or a tube containing the encapsulated drug.…”

Section: Measuring Ultrasound-triggered Release Of Dox From Pluronicmentioning

confidence: 99%

“…The emissions were collected using a fiber optic collector and filtered to remove the excitation wavelength. Then these emissions were quantified using a photodetector and an oscilloscope and subsequently stored on a computer for further analysis [3,4].…”

Section: Measuring Ultrasound-triggered Release Of Dox From Pluronicmentioning

confidence: 99%

“…The aim of such controlled delivery is to minimize any damage to non-targeted tissues. Previously, our research group has shown that ultrasound can be used to control the release of Dox and Ruboxyl (a paramagnetic analogue of Dox) from the core of stabilized as well as non-stabilized micelles [1][2][3][4][5][6][7][8][9][10][11][12][13]. Preliminary work with an in vivo rat model showed that Dox activity can be enhanced by ultrasound in one region, while in an adjacent region there is little or no effect of the drug.…”

Section: Introductionmentioning

confidence: 99%

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Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models

Stevenson-Abouelnasr

Husseini

Pitt

2007

Colloids and Surfaces B: Biointerfaces

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The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the acoustically-triggered Doxorubicin (Dox) release and re-encapsulation from Pluronic P105 micelles. The four mechanisms are: micelle destruction; destruction of cavitating nuclei; reassembly of micelles, and the re-encapsulation of Dox. The first mechanism, the destruction of micelles during insonation, causes the release of Dox into solution. The micelles are destroyed because of cavitation events produced by collapsing nuclei, or bubbles in the insonated solution. The second mechanism, the slow destruction of cavitating nuclei, results in a slow partial recovery phase, when a small amount of Dox is re-encapsulated. The third and fourth mechanisms, the reassembly of micelles and the re-encapsulatin of Dox, are independent of ultrasound. These two mechanism are responsible for maintaining the drug release at a partial level, and for recovery after insonation ceases. A normal distribution was used to describe micellar size. Parameters for the model were determined based upon the best observed fit to experimental data. The resulting model provides a good approximation to experimental data for the release of Dox from Pluronic P105 micelles.

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Section: Introductionmentioning

confidence: 80%

“…The same drug concentration was also prepared in PBS. Additional details have been published earlier [3,4].…”

Section: Drug Encapsulation In Pluronic Micellesmentioning

confidence: 99%

“…Details were described previously [3,4]. Briefly, an argon-ion laser beam at 488 nm was directed to either a cuvette or a tube containing the encapsulated drug.…”

Section: Measuring Ultrasound-triggered Release Of Dox From Pluronicmentioning

confidence: 99%

Section: Measuring Ultrasound-triggered Release Of Dox From Pluronicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models

Stevenson-Abouelnasr

Husseini

Pitt

2007

Colloids and Surfaces B: Biointerfaces

Self Cite

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Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

Pan,

Huang,

Nie

et al. 2023

Advanced Materials

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Neurological diseases are a major global health challenge, affecting hundreds of millions of people worldwide. Ultrasound therapy plays an irreplaceable role in the treatment of neurological diseases due to its non‐invasive, highly focused, and strong tissue penetration capabilities. However, the complexity of brain and nervous system and the safety risks associated with prolonged exposure to ultrasound therapy severely limit the applicability of ultrasound therapy. Ultrasound‐sensitive intelligent nanosystems (USINs) are a novel therapeutic strategy for neurological diseases that bring greater spatiotemporal controllability and improved safety to overcome these challenges. This review provides a detailed overview of therapeutic strategies and clinical advances of ultrasound in neurological diseases, focusing on the potential of USINs‐based ultrasound in the treatment of neurological diseases. Based on the physical and chemical effects induced by ultrasound, rational design of USINs is a prerequisite for improving the efficacy of ultrasound therapy. Recent developments of ultrasound‐sensitive nanocarriers and nanoagents are systemically reviewed. Finally, the challenges and developing prospects of USINs are discussed in depth, with a view to providing useful insights and guidance for efficient ultrasound treatment of neurological diseases.This article is protected by copyright. All rights reserved

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Stretch‐Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates

et al. 2016

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The concept of using crack propagation in polymeric materials to control drug release and its first demonstration are reported. The composite drug delivery system consists of highly-textured superhydrophobic electrosprayed microparticle coatings, composed of biodegradable and biocompatible polymers poly(caprolactone) and poly(glycerol monostearate carbonate-cocaprolactone), and a cellulose/polyester core. The release of entrapped agents is controlled by the magnitude of applied strain, resulting in a graded response from water infiltration through the propagating patterned cracks in the coating. Strain-dependent delivery of the anticancer agents cisplatin and 7-ethyl-10-hydroxycamptothecin to esophageal cancer cells (OE33) in vitro is observed. Finally the device is integrated with an esophageal stent to demonstrate delivery of fluorescein diacetate, using applied tension, to an ex vivo esophagus. Graphical AbstactDrug release is controlled by the magnitude of applied tensile strain through superhydrophobic composites. Strain-dependent in vitro delivery of anticancer agents (cisplatin and 7-ethyl-10-hydroxycamptothecin) to OE33 esophageal cancer cells and ex vivo delivery of fluorescein diacetate with esophageal stent integrated device are demonstrated. This system provides mechanoresponsive delivery for both hydrophilic and lipophilic compounds.Correspondence to: Mark W. Grinstaff.[ †] Authors have contributed equally to this work.Supporting information for this article is given via a link at the end of the document Mechanoresponsive polymeric materials are of significant interest as key functional elements in self-healing assemblies, [1] sensors and electronics, [2] and biology/medicine. [3] Consequently, mechanoresponsive materials are actively being developed that respond to mechanical stimuli such as compression, [4] tension, [5] shear, [6] or ultrasound. [7] Implanted medical devices also experience many of these forces, and even exert their own mechanical forces during use (e.g., stents). [8] Our approach to designing functional mechanoresponsive materials for drug delivery uses crack propagation failure modes of composite materials to control drug release. We hypothesized that crack formation could be initiated and propagated through superhydrophobic coatings on a multilayered drug delivery system by applying tension, with consequent device wetting and drug release. Given our interests in triggered drug release from polymeric [9] and superhydrophobic [10] materials, we realized an opportunity to design and evaluate such a new drug delivery system for an esophageal stent. Herein, we report: (1) the fabrication of a multilayered electrosprayed polymeric device; (2) the entrapment and subsequent controlled release of both hydrophilic and lipophilic agents under various applied strains; (3) analysis of the crack propagation mechanism with determination of the fracture toughness and critical strain energy release rate; (4) the demonstration of in vitro tension-mediated delivery of cisplatin...

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The role of cavitation in acoustically activated drug delivery

Cited by 156 publications

References 44 publications

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models

Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models

Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

Stretch‐Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates

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