Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

Pan, Xueting; Huang, Wenping; Nie, Guangjun; Wang, Changyong; Wang, Hai

doi:10.1002/adma.202303180

Cited by 7 publications

(2 citation statements)

References 304 publications

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“…In addition, these materials can be noninvasively implanted into the body and achieve satisfactory therapeutic effects through precise remote control, significantly enhancing their clinical applicability. [145]…”

Section: Nervous Systemmentioning

confidence: 99%

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Li,

Pan,

Wang

et al. 2024

Small Science

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Tissue damage often causes considerable suffering to patients due to slow recovery and poor prognosis. The use of electroactive materials to deliver biophysical signals plays a key role in regulating tissue regeneration processes. Among these materials, piezoelectric materials have unique electromechanical conversion capabilities, making them suitable for use as cell scaffolds. They can deform and emit electrical signals in response to external stimuli, thereby regulating cell proliferation and differentiation. In this review, recent advances are presented in piezoelectric materials as physical signaling mediators that regulate cell differentiation. The basic mechanisms, classification of these materials, and their different applications in tissue regeneration are described. Finally, a comprehensive discussion of current challenges and prospects in the field is provided. Together, existing experimental results basically show that piezoelectric materials can improve the process and effect of tissue repair, providing new technical options for the development of tissue engineering in the future.

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Section: Nervous Systemmentioning

confidence: 99%

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Li,

Pan,

Wang

et al. 2024

Small Science

Self Cite

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“…Several stimuli-responsive drug depots have been developed, including those responsive to temperature, ultrasound, magnetic field, light, and pH [ 8 ]. Among the various stimuli, ultrasound has attractive features due to its noninvasive, patient-friendly delivery; deep tissue penetration; thermal and mechanical modulation; and direct cytosolic drug delivery [ 9 , 10 ]. Microbubbles, polymeric nanoparticles, and recently echogenic exosomes have been explored in regard to ultrasound-mediated delivery [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Ultrasound-Responsive Amyloid Formulation

Ismail,

Kanapathipillai

2024

Pharmaceuticals

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Amyloid aggregates have attracted significant interest in regard to diverse biomedical applications, particularly in the field of drug delivery. Here, we report novel amyloid aggregates based on a 12-amino-acid peptide from the amyloidogenic region of the receptor-interacting kinase 3 (RIP3) protein and a thermoresponsive triblock copolymer, namely, Pluronic F127 (RIP3/F127). Physicochemical characterization was performed to determine the aggregation size, morphology, and stimuli-responsive properties. The potential of the aggregates as a drug depot was assessed in lung cancer cells, using Doxorubicin (Dox) as a model drug. The results show that RIP3 and RIP3/F127 exhibit amyloidogenic properties. Further, the RIP3/F127 amyloids exhibited significant ultrasound-responsive properties compared to amyloid aggregates without Pluronic F127. Moreover, the RIP3/F127/Dox amyloid formulations that were subjected to ultrasound treatment exhibited greater toxicity to lung cancer cells compared to that of Dox alone at equal concentrations. Overall, the results from this proof-of-concept study show that amyloidogenic peptide aggregates with stimuli-responsive properties can be utilized as efficient drug delivery depots.

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Engineered Nanostructures for Sonothermal Therapy

Hakimi,

Ma,

Karimi

et al. 2024

Adv Funct Materials

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Sonothermal therapy (STT) has become increasingly attractive recently as a noninvasive, safe, and nonionizing methodology. STT, as a newly emerging heat‐enabled therapeutic approach, can rely on built‐in bubble cavitation and thermal energy‐electron recombination of sonothermal agents (STAs) activated by ultrasound (US) irradiation. In this domain, STT‐enabled nanomedicine is considered a potential treatment for abnormal cell killing and normal cell renewing, which addresses the drawbacks of nonspecific heating in conventional microbubbles, side effects, and poor tissue penetration of available thermal‐based therapies. Herein, a comprehensive review on the efficiency of STT in tumor ablation, infection therapy, and tissue regeneration is presented. Moreover, this review focuses on the benefits of STT as a therapeutic hot topic that can be used for nonantibiotic treatments, noninvasive heat‐activated tissue regeneration, and highly efficient local cancer therapy. In addition, rational design of STAs, mechanistic innovations, and prospects of STT will also be provided.

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Ultrasound‐Sensitive Intelligent Nanosystems: A Promising Strategy for the Treatment of Neurological Diseases

Cited by 7 publications

References 304 publications

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Novel Ultrasound-Responsive Amyloid Formulation

Engineered Nanostructures for Sonothermal Therapy

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