In this work, unmanned aerial vehicle-based non-destructive testing methods for concrete structures are evaluated and developed. There exists a need for improved infrastructure inspection techniques with increased expediency. Unmanned aerial vehicles (UAVs) are highly mobile and have shown promise towards achieving this directive, but more work is required to adapt traditional NDT methods to be UAV-compatible. To this end, concrete sounding techniques were evaluated with a quantitative acoustic frequency analysis procedure on a series of concrete slabs. One such method was adapted for use with a UAV and was used to detect subsurface voids in one of the concrete samples and offer a means of depth estimation. This work was complemented with experiments concerning UAVbased visual and infrared imaging techniques already in practice for UAV-based concrete inspection. Together, findings indicate the strengths and weaknesses of the NDTs tested and suggest further improvements for UAV-based NDTs and inspection strategies moving forward. Development of a novel sensor platform for UAV-based measurement, as well as results of an actual bridge inspection using infrared and optical methods demonstrate the present capabilities of the UAV-based instrumentation.