Acoustic radiation force impulse elastography in evaluation of triple-negative breast cancer: A preliminary experience

Wan, Jieqing; Wu, Rong; Yao, Meicun; Xu, Gelin; Liu, Hui; Pu, Huan; Xiang, Li‐Hua; Zhang, Shupin

doi:10.3233/ch-170363

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Even if the combination of ultrasound elastography with Doppler ultrasound is performed, not all TNBC lesions can be identified [38]. In view of the highly invasiveness and poor prognosis of TNBC, more and more imaging methods were used to distinguish TNBC [39][40][41]. Ultrasound elastography [39], contrast-enhanced ultrasound [40], and analysis of breast ultrasound images by machine learning [41] were used for TNBC detection, and some of the latest work may enhance the image analysis in the US examination [42].…”

Section: Discussionmentioning

confidence: 99%

Calcification, Posterior Acoustic, and Blood Flow: Ultrasonic Characteristics of Triple-Negative Breast Cancer

Wang

Zou

Shen

et al. 2022

Journal of Healthcare Engineering

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Previous studies suggest that triple-negative breast cancer (TNBC) may have unique imaging characteristics, however, studies focused on the imaging characteristics of TNBC are still limited. The aim of the present study is to analyze the ultrasonic characteristics of TNBC and to provide more reliable information on imaging diagnosis of TNBC. This retrospective study was performed including 162 TNBC patients with 184 TNBC lesions. 174 non-TNBC cases with 196 lesions were used as the control group. The median size of TNBC lesions and non-TNBC lesions were 23 mm × 16 mm and 21 mm × 15 mm, respectively. The shape of most breast cancer lesions was irregular. However, 15.30% (28/183) TNBC lesions and 16.84% (33/196) non-TNBC lesions were oval-shaped. Most breast cancer lesions (79.78% TNBC & 85.71% non-TNBC) were ill-defined. In comparison to non-TNBC, the distinctive ultrasonic characteristics of TNBC were summarized as three features: calcifications, posterior acoustic, and blood flow. Microcalcifications was less common in non-TNBC. The remarkable posterior acoustic characteristics on TNBC were no posterior acoustic features (136, 73.91%). Avascular pattern (21.74%) was also more common in TNBC. The other feature of TNBC was markedly hypoechoic lesions (23.91%). The above-mentioned differences between TNBC and non-TNBC were significant. 93.48% TBNC and 94.39% non–TNBC lesions were in BI-RADS-US category of 4A-5. The results indicate that TNBC has some distinctive ultrasound characteristics. Ultrasound is a useful adjunct in early detection of breast cancer. A combination of ultrasound with mammography is excellent for detecting breast cancer.

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Section: Discussionmentioning

confidence: 99%

Calcification, Posterior Acoustic, and Blood Flow: Ultrasonic Characteristics of Triple-Negative Breast Cancer

Wang

Zou

Shen

et al. 2022

Journal of Healthcare Engineering

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“…TNBC had the highest mean shear wave velocity (SWVmean) (7.36 m/s ±1.83) compared to other aggressive breast cancers, and the qualitative VTI score measurement was also higher than that of ER+ tumors and HER2+ tumors, according to Wan Jing et al [38] , who evaluated the mean tumor hardness of 234 breast cancers with ARFI. High VTI score, ambiguous VTI boundary, and SWV ≥3.51 m/s were reported to be substantially linked with TNBC by Pu Huan et al [39] .…”

Section: Acoustic Radiation Force Impulse (Arfi)mentioning

confidence: 99%

Status and Progress of Multimodal Ultrasound Diagnosis of Triple-negative Breast Cancer

2023

IJFM

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Breast cancer is a highly heterogeneous cancer that is exceptionally harmful to women. It is generally divided by immunohistochemistry into four primary molecular subtypes: triple-negative (TN), human epidermal growth factor receptor 2 (HER2) overexpression, luminal A, and luminal B. Different breast cancer molecular subtypes exhibit diverse biological traits, clinical symptoms, therapeutic responses, and prognoses. Among them, triple-negative breast cancer (TNBC) is a highly malignant subtype with no particular treatment modalities and an inferior prognosis. As diverse ultrasonographies can offer complementing information on various features of breast cancer, multimodal ultrasonography provides a more reliable method for predicting TNBC than conventional ultrasound alone. This article reviews the research status and progress of multimodal ultrasound diagnostic techniques such as traditional ultrasound combined with sonoelastography (SE), contrast ultrasonography (CEUS), three-dimensional ultrasound (3D-US) and superb microvascular imaging (SMI) in predicting triple-negative breast cancer. It aims to use ultrasound diagnosis technology to predict TNBC and provide a reference for guiding clinical treatment and enhancing prognosis.

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“…Ultrasonography is an effective tool for evaluating fibrotic lesions within the SCM and for measuring muscle or mass thickness and is therefore widely used in musculoskeletal medicine [11,12]. Ultrasound elastography has been used as a noninvasive method for evaluating and detecting tumors in various tissues, including the liver, breast, kidney, thyroid, and spleen, and has also been developed to allow the objective assessment of muscle stiffness [13][14][15][16]. Acoustic radiation force impulse (ARFI) elastography is an ultrasound elastography technique in which stress or force is applied to deform the target tissue, and the tissue's mechanical properties are then evaluated by detecting this internal physiological motion.…”

Section: Introductionmentioning

confidence: 99%

Changes in Muscle Stiffness in Infants with Congenital Muscular Torticollis

et al. 2019

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Congenital muscular torticollis (CMT) results from unilateral shortening of the sternocleidomastoid (SCM) muscle, usually associated with a fibrotic mass. Although CMT may resolve with physical therapy, some cases persist, resulting in long-term musculoskeletal problems. It is therefore helpful to be able to monitor and predict the outcomes of physical therapy. Shear-wave velocity (SWV) determined by acoustic radiation force impulse (ARFI) elastography can provide a quantitative measure of muscle stiffness. We therefore measured SCM SWV in 22 infants with unilateral CMT before and after 3 months of physical therapy and evaluated the relationships between SWV and SCM thickness and various clinical features, including cervical range of motion (ROM). SWV was initially higher and the ROM was smaller in affected muscles before physical therapy. SWV decreased significantly (2.33 ± 0.47 to 1.56 ± 0.63 m/s, p < 0.001), indicating reduced stiffness, and muscle thickness also decreased after physical therapy (15.64 ± 5.24 to 11.36 ± 5.71 mm, p < 0.001), both in line with increased neck ROM of rotation (64.77 ± 18.87 to 87.27 ± 6.31 • , p < 0.001) and lateral flexion (37.50 ± 11.31 to 53.64 ± 9.41 • , p < 0.001). However, the improved ROM more closely reflected the changes in SWV than in muscle thickness. These results suggest that a change in SWV detected by ARFI elastography could help to predict improvements in clinical outcomes, such as stiffness-related loss of motion, in patients with CMT undergoing physical therapy.

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Acoustic radiation force impulse elastography in evaluation of triple-negative breast cancer: A preliminary experience

Abstract: Triple-negative breast cancer is associated with high stiffness scores and SWV in ARFI. The latter may be considered a useful complementary tool in evaluation of triple-negative breast cancer.

Cited by 8 publications

References 27 publications

Calcification, Posterior Acoustic, and Blood Flow: Ultrasonic Characteristics of Triple-Negative Breast Cancer

Calcification, Posterior Acoustic, and Blood Flow: Ultrasonic Characteristics of Triple-Negative Breast Cancer

Status and Progress of Multimodal Ultrasound Diagnosis of Triple-negative Breast Cancer

Changes in Muscle Stiffness in Infants with Congenital Muscular Torticollis

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