2021
DOI: 10.1039/d1lc00261a
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Acoustic valves in microfluidic channels for droplet manipulation

Abstract: A novel concept of an acoustic valve in the microfluidic channel is reported in this work for the first time. The acoustic valve is a controllable virtual barrier constructed by...

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Cited by 32 publications
(22 citation statements)
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“…Using a traveling surface acoustic wave system enabled on-demand droplet generation, selective cell encapsulation, and pico-injection of reagents into existing droplets. Acoustic valves are controllable virtual barriers constructed with focused acoustic fields, which can also serve to manipulate droplets . Unlike devices based on surface acoustic waves, acoustic valves do not use an acoustic field to drive droplets but only block channel branches.…”
Section: Droplet Microfluidicsmentioning
confidence: 99%
See 1 more Smart Citation
“…Using a traveling surface acoustic wave system enabled on-demand droplet generation, selective cell encapsulation, and pico-injection of reagents into existing droplets. Acoustic valves are controllable virtual barriers constructed with focused acoustic fields, which can also serve to manipulate droplets . Unlike devices based on surface acoustic waves, acoustic valves do not use an acoustic field to drive droplets but only block channel branches.…”
Section: Droplet Microfluidicsmentioning
confidence: 99%
“…Acoustic valves are controllable virtual barriers constructed with focused acoustic fields, which can also serve to manipulate droplets. 42 Unlike devices based on surface acoustic waves, acoustic valves do not use an acoustic field to drive droplets but only block channel branches. Zhang et al developed a pneumatic technique based on dynamic rails that, contrary to other active methods, does not require an additional fabrication step or peripheral equipment other than a pressure source.…”
Section: ■ Instrumentationmentioning
confidence: 99%
“…As an alternative to mechanical pumps and valves, using acoustics has been proposed. 9 In an acoustic microfluidic ( acoustofluidic ) chip, ultrasound transducers create acoustic waves, which can be used for transporting particles, 10 12 cells, 13 15 or droplets. 16 18 More than just transporting, acoustics can also be used for sorting particles 10 , 19 , 20 or droplets, 18 merging droplets, 18 , 21 , 22 and splitting droplets.…”
Section: Introductionmentioning
confidence: 99%
“…As an alternative to mechanical pumps and valves, using acoustics has been proposed . In an acoustic microfluidic ( acoustofluidic ) chip, ultrasound transducers create acoustic waves, which can be used for transporting particles, cells, or droplets. More than just transporting, acoustics can also be used for sorting particles ,, or droplets, merging droplets, ,, and splitting droplets. Manipulating multiple solid objects by shaping the acoustic fields has been demonstrated, e.g., by using holographic acoustic traps ,, or by using time-varying signals. ,, Objects can be manipulated acoustically on the surface of the device or within a medium, using transverse waves, ,, bulk acoustic waves, ,, or surface acoustic waves. ,,, …”
Section: Introductionmentioning
confidence: 99%
“…27 In contrast, droplet manipulation using SAW technology refers to actuating the droplet using the acoustic pressure gradient formed inside the droplet, which is coupled with the SAW (where the droplet has a size much larger than the wavelength of the SAW). [28][29][30] Specifically, when the droplet is placed in the propagation path of the Travelling Surface Acoustic Wave (TSAW, which can be formed on the surface of a piezoelectric substrate by exciting the InterDigital Transducers, IDTs), the acoustic energy can be radiated into the droplets to create an acoustic pressure gradient within them, 31 and a sufficiently large pressure gradient will drive the droplets. [32][33][34] This SAW-based droplet manipulation technology shows several advantages, including small equipment size, 35,36 convenience for an experimental setup and modular integration, [37][38][39] features which have been widely employed in some 'lab-on-a-chip' applications, such as on-chip Polymerase Chain Reactions (PCR), 1,40 on-chip collection of microorganisms, 41 and the transmission and merging of sample reagents.…”
Section: Introductionmentioning
confidence: 99%