Acoustic wave based MEMS devices for biosensing applications

Voiculescu, Ioana; Nordin, Anis Nurashikin

doi:10.1016/j.bios.2011.12.041

Cited by 195 publications

(107 citation statements)

References 27 publications

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“…The application of an a.c. voltage to the IDEs will create an oscillating strain within the material that will create waves that travel parallel to the surface. As the acoustic energy within SAW devices is confined to the surface they are highly sensitive to any changes in mass that might occur at the surface, such as the binding of analyte molecules to a recognition layer (Gronewold, 2007;Länge, et al, 2008;Voiculescu and Nordin, 2012). Variations of SAW devices include Shear-Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW) and Love Wave (LW) devices (Rocha-Gaso et al, 2009).…”

Section: Surface Acoustic Wave Devicesmentioning

confidence: 99%

“…Delay-line sensors function by detecting changes to the time taken for the waves to traverse the sensing region and the amplitude of the received waves, caused by analyte molecules binding to the sensing region (Rocha-Gaso et al, 2009;Voiculescu and Nordin, 2012). In resonator devices a single set of IDEs are situated centrally between reflectors such that standing waves are created within an area encompassing the sensing region (Fig.…”

Section: Targetmentioning

confidence: 99%

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Micro- and nano-structure based oligonucleotide sensors

Ferrier

Shaver

Hands

2015

Biosensors and Bioelectronics

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This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporated into hand-held devices and their suitability for mass production means that, out of the different approaches to oligonucleotide detection, they are the most suitable for commercialisation. This review discusses the advantages of micro- and nano-structure based sensors and covers the various oligonucleotide detection techniques that have been developed to date. These include: Bulk Acoustic Wave and Surface Acoustic Wave devices, micro- and nano-cantilever sensors, gene Field Effect Transistors, and nanowire and nanopore based sensors. Oligonucleotide immobilisation techniques are also discussed.

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Section: Surface Acoustic Wave Devicesmentioning

confidence: 99%

Section: Targetmentioning

confidence: 99%

Micro- and nano-structure based oligonucleotide sensors

Ferrier

Shaver

Hands

2015

Biosensors and Bioelectronics

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“…Furthermore, analyte preprocessing is often necessary for obtaining optimal results with these technologies (3)(4)(5)(6). In contrast, mass detection devices based on piezoelectric materials capable of generating surface acoustic waves (SAW) that can be applied to biological samples have long been recognized to yield relatively simple, robust, and rapid measurements in a real-time mode (4,(6)(7)(8)(9)(10). In particular, this technology has the potential to enable label-free, rapid, cost-effective, and sensitive detection of pathogens under challenging conditions, including emergency situations.…”

mentioning

confidence: 99%

Rapid Detection of Human Immunodeficiency Virus Types 1 and 2 by Use of an Improved Piezoelectric Biosensor

et al. 2013

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c Disasters can create situations in which blood donations can save lives. However, in emergency situations and when resources are depleted, on-site blood donations require the rapid and accurate detection of blood-borne pathogens, including human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). Techniques such as PCR and antibody capture by an enzyme-linked immunosorbent assay (ELISA) for HIV-1 and HIV-2 are precise but time-consuming and require sophisticated equipment that is not compatible with emergency point-of-care requirements. We describe here a prototype biosensor based on piezoelectric materials functionalized with specific antibodies against HIV-1 and HIV-2. We show the rapid and accurate detection of HIV-1 and HIV-2 in both simple and complex solutions, including human serum, and in the presence of a cross-confounding virus. We report detection limits of 12 50% tissue culture infective doses (TCID 50 s) for HIV-1 and 87 TCID 50 s for HIV-2. The accuracy, precision of measurements, and operation of the prototype biosensor compared favorably to those for nucleic acid amplification. We conclude that the biosensor has significant promise as a successful point-of-care diagnostic device for use in emergency field applications requiring rapid and reliable testing for blood-borne pathogens. It is readily appreciated that in disaster situations, the efficiency of the emergency medical response can be greatly hampered by factors that can overwhelm or eliminate medical care resources, such as having a larger-than-expected number of trauma victims in need of untainted blood products or, on the positive side, having a larger-than-expected number of donors whose blood needs to be tested rapidly for the presence of potential blood-borne pathogens, including HIV (1). However, guidelines for which technologies are most reliable in such situations are lacking, and sophisticated laboratory equipment and aseptic conditions for the detection of HIV are not amenable for use in emergency situations, such as on-site medical care sites or rudimentary field laboratories and hospitals. Thus, there is a great need for robust, simple, reliable, and rapid point-of-care detection devices for emergency conditions (1, 2).Typical detection methods for the diagnosis of blood-borne pathogens, such as HIV, as established widely in medical laboratories, include the enzyme-linked immunosorbent assay (ELISA) and nucleic acid amplification by PCR. However, ELISAs and PCRs require specific reagents, such as special buffers and enzymes, and sophisticated, large, and costly pieces of equipment, not all of which are amenable to field application. Furthermore, analyte preprocessing is often necessary for obtaining optimal results with these technologies (3-6). In contrast, mass detection devices based on piezoelectric materials capable of generating surface acoustic waves (SAW) that can be applied to biological samples have long been recognized to yield relatively simple, robust, and rapid measurements in a real-time mode (4, 6-10). In p...

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“…The fundamental resonant frequency is related to the acoustic wave velocity as given as a following: Where: f 0 , v 0 and λ are the unperturbed frequency, the unperturbed velocity and wavelength of SAW, respectively [14]. Depending on the principles of the generation of SAWs and its interaction with the medium, the SAW devices are used as sensors [15,16] or as biosensors for biological medium [17,18].…”

Section: Introductionmentioning

confidence: 99%

Modelling and Simulation of Microparticles Separation using Standing Surface Acoustic Waves (SSAWs) Microfluidic Devices for Biomedical Applications

Soliman¹,

Eldosoky²,

Taha³

2015

IJCA

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The design of significant and powerful standing surface acoustic wave (SSAW) microfluidic device for microparticles separation for biomedical applications is depending on the dimensions of microchannels for the collecting microparticles. For this purpose, precise calculations of the displacement of microparticles in the working area of SSAW microfluidic device are required. In this paper, the theory and principles of using SSAW microfluidic devices for particles separation are described. The almost published papers in this field had taken into account only the effect of SSAW and viscous drag forces, but the microparticles in the separation process can be affected by other forces. Therefore, the forces acting on the microparticles in fluid flow in SSAW microfluidic devices such as hydrodynamic and diffusion forces are analyzed by mathematical models. Also, the SSAW force is affected by Rayleigh angle, therefore, the SSAW force with the effect of Rayleigh angle which acting on the microparticles is analyzed by mathematical model. The simulation programs are also built by Matlab program to calculate the displacement of microparticles based on the effect of SSAW and viscous drag forces alone; and based on the effect of SSAW with Rayleigh angle effect, viscous drag, hydrodynamic, and diffusion forces. Two types of microparticles different in size and two types of microparticles different in density are separately simulated to verify these programs and show the effects of this analysis. The analysis and simulation of these effects are positively led to more accurate calculations of the displacement of microparticles in the SSAW microfluidic device.

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Acoustic wave based MEMS devices for biosensing applications

Cited by 195 publications

References 27 publications

Micro- and nano-structure based oligonucleotide sensors

Micro- and nano-structure based oligonucleotide sensors

Rapid Detection of Human Immunodeficiency Virus Types 1 and 2 by Use of an Improved Piezoelectric Biosensor

Modelling and Simulation of Microparticles Separation using Standing Surface Acoustic Waves (SSAWs) Microfluidic Devices for Biomedical Applications

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