Micro- and nano-structure based oligonucleotide sensors

Abstract

This paper presents a review of micro- and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporated into hand-held devices and their suitability for mass production means that, out of the different approaches to oligonucleotide detection, they are the most suitable for commercialisation. This review discusses the advantages of micro- and nano-structure based sensors and covers the various oligonucleotide detection techniques that have been developed to date. These include: Bulk Acoustic Wave and Surface Acoustic Wave devices, micro- and nano-cantilever sensors, gene Field Effect Transistors, and nanowire and nanopore based sensors. Oligonucleotide immobilisation techniques are also discussed.

A review of microfabricated electrochemical biosensors for DNA detection

“…Micro-and nano-structure based oligonucleotide sensors 2015 Miniaturized DNA biosensors, not electrochemical (Ferrier et al, 2015) Metal oxide nanoparticles in electrochemical sensing and biosensing: a review…”

Biosensors and bioelectronics on smartphone for portable biochemical detection

“…With the help of Micro-Electro-Mechanical System (MEMS) and nanotechnology, biosensors can be miniaturized to micro-and nano-scale, and integrated into lab-on-a-chip devices as the sensitive arrays for biosensor detections (Voiculescu and Nordin, 2012;Ferrier et al, 2015). However, although gaining great improvements in sensitivity and automation, most of micro-/nano-biosensors still require cumbersome readout devices to operate sensing processes, detect response signals, analyze data, and display results.…”

Recent advances in lab-on-a-chip for biosensing applications

“…For a quick overview, the main facts and findings from the cited papers are summarized in several tables. The readers are also referred to recent related reviews that might be of interest Ferrier et al, 2015;Ge et al, 2014;Holzinger et al, 2014;Jiang et al, 2014;Kelley et al, 2014;Muzyka, 2014;Reenen et al, 2014;Rocha-Santos, 2014;Sang et al, 2014).…”