Acoustically Evoked Potential: Dependence Upon Age

Spink, U.; Johannsen, H. S.; Pirsig, W

doi:10.3109/01050397909076296

Cited by 15 publications

(8 citation statements)

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“…Papancoulaou et al (1984), Tremblay et al (2004), and Goodin (1978) found amplitudes to decrease with increasing age while Pfefferbaum et al (1980) Kim et al (Kim et al 2012) and Polich (1997) found signficant increases or trends toward larger amplitudes with increasing age. Finally, Harris et al (2008) Laffont et al (1989) and Spink et al (1979) found no effects of age. Most studies of auditory senescence in general, and of N1-P2 in particular, are afflicted by small samples and inadequate control for hearing loss, which typically accompanies aging and can confound estimated aging effects on N1-P2.…”

Section: Introductionmentioning

confidence: 87%

“…Most found that N1 and/or P2 latencies increased with increasing age (Papancoulaou et al 1984; Vanhanen et al 1996; Tremblay et al 2004; Harris et al 2007; Harris et al 2008; Lijffijt et al 2009; Kim et al 2012) though some did not (Spink et al 1979; Laffont et al 1989). N1 and/or P2 amplitude changes with age were perhaps even more variable.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

et al. 2016

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OBJECTIVES-(1) Characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory evoked potentials (CAEPs) separate from the effects of normal aging; and (2) determine if the disease-related effects are modified by insulin dependence. DESIGN-A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age and CAEPs in randomly selected participants with (N=108) and without (N=114) the disease and who had no more than a moderate hearing loss. Participants with DM were classified as insulin-dependent (IDDM, N=47) or non-insulin-dependent (NIDDM, N=61). Other DM measures included concurrent serum glucose, HbA1c and duration of disease. CAEPs were evoked using a passive homogeneous paradigm (single repeating stimulus) by suprathreshold tones presented to the right ear, left ear, or both ears. Outcome measures were adjusted for the pure tone threshold average (PTA) for frequencies of 0.5, 1, and 2 kHz and analyzed for differences in age effects between participant groups using multiple regression.RESULTS-There is little variation across test ear conditions (left, right, binaural) on any CAEP peak in any of the groups. Among no-DM controls, P2 latency increases about 9 ms per decade of life. DM is associated with an additional delay in the P2 latency of 7 and 9 ms for the IDDM and NIDDM groups, respectively. Moreover, the slope of the function relating P2 latency with age is similar across participant groups and thus the DM effect appears constant across age. Effects on N1 latency are considerably weaker, with age effects of less than 4 ms per decade across all groups, and DM effects of only 2 (IDDM) or 3 ms (NIDDM). In the NIDDM group, the slope relating N1 latency to age is steeper relative to that observed for the no-DM group, providing some evidence of accelerated "aging" for this CAEP peak. DM does not substantially reduce N1-P2 U.S. Department of Veterans Affairs VA Author ManuscriptVA Author Manuscript VA Author Manuscript amplitude and age relationships with N1-P2 amplitude are effectively absent. There is no association between PTA at .5, 1, and 2 kHz and any aspect of CAEPs in this cohort.CONCLUSIONS-In a large cohort of Veterans, we found that type 2 DM is associated with prolonged N1 and P2 latencies regardless of whether insulin is required to manage the disease and independent of peripheral hearing thresholds. The DM-related effects on CAEP latencies are three fold greater for P2 compared with N1, and there is little support that at the cortical level, IDDM participants had poorer responses compared with NIDDM participants, although their responses were more variable. Overall, these results indicate that DM is associated with slowed pre-attentive neural conduction. Moreover, the observed 7-9 ms P2 latency delay due to DM is substantial compared with normal age changes in P2, which are 9 ms per decade of life in this cohort. Results also suggest that whereas N1 latency changes with age are more pronounced among individuals w...

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

et al. 2016

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“…Meanwhile, Spink et al [18] studied acoustically evoked potentials and found that the slow components of auditory evoked potentials in the elderly were shorter than those of a younger group. They inter preted their findings as a sign of a decreased efferent inhi bition of several nuclei of the auditory pathway in the old er subjects.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Aging on Auditory Brainstem Response and Electrocochleography in the Elderly

Oku

Hasegewa

1997

ORL

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Auditory brainstem responses and simultaneous transtympanic electrocochleographies were investigated in 92 subjects aged between 50 and 89 years with normal hearing or mild presbycusis. Subjects were classified into four age-related groups: 16 subjects in the sixth decade, 28 in the seventh decade, 32 in the eighth decade and 16 in the ninth decade. Thirty young subjects with normal hearing aged 20–29 years were chosen as controls. The result showed progressive delay of wave I (or action potential: AP), wave III and wave V and lengthening of the interpeak intervals (IPIs) of waves III-V and I-V in the subjects aged 50-79 years. In the subjects in the ninth decade, shortening of IPIs of waves I–III and I–V was noted in spite of further delays of wave I. The amplitude of APs on electrocochleography decreased in the groups with mild presbycusis. Both the lengthening and shortening of IPIs might be electrophysiological alterations occurring with aging in the central auditory pathways.

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“…Goodin et al, (1978) reported a similar finding in a comparable subject population and experimental situation. Spink et al, (1979) examined the effects of different stimulus intensities on a small sample of elderly (mean age 63) and young (mean age 22) adults. Only subjects with hearing loss less than 10 dB at 1000 Hz were included, and stimuli were presented at intensities relative to SL.…”

Section: Age Effects On Sensory Epsmentioning

confidence: 99%

ERPs and Psychopathology I. Behavioral Process Issues^a

Roth

Tecce

Pfefferbaum

et al. 1984

Annals of the New York Academy of Sciences

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The clinical study of ERPs has an inherent defect--a self-selection of clinical populations that hampers equating of clinically defined groups on factors extraneous to the independent variables. Such ex post facto studies increase the likelihood of confounding variables in the interpretation of findings. Hence, the development of lawful relationships between clinical variables and ERPs is impeded and the fulfillment of description, explanation, prediction, and control in brain science is thwarted. Proper methodologies and theory development can increase the likelihood of establishing these lawful relationships. One methodology of potential value in the clinical application of ERPs, particularly in studies of aging, is that of divided attention. Two promising theoretical developments in the understanding of brain functioning and aging are the distraction-arousal hypothesis and the controlled-automatic attention model. The evaluation of ERPs in the study of brain-behavior relations in clinical populations might be facilitated by the differentiation of concurrent, predictive, content, and construct validities.

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Acoustically Evoked Potential: Dependence Upon Age

Cited by 15 publications

References 15 publications

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

The Influence of Aging on Auditory Brainstem Response and Electrocochleography in the Elderly

ERPs and Psychopathology I. Behavioral Process Issues^a

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Acoustically Evoked Potential: Dependence Upon Age

Cited by 15 publications

References 15 publications

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging

The Influence of Aging on Auditory Brainstem Response and Electrocochleography in the Elderly

ERPs and Psychopathology I. Behavioral Process Issuesa

Contact Info

Product

Resources

About

ERPs and Psychopathology I. Behavioral Process Issues^a