Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy

Barragan, Andres; Preston, Chet; Alvarez, Alex; Bera, Tushar Kanti; Qin, Yexian; Weinand, Martin E.; Kasoff, Willard S.; Witte, Russell S.

doi:10.1088/1741-2552/abb63a

Cited by 20 publications

(13 citation statements)

References 26 publications

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“…This study achieved the first SSVEP measurement with millimeter spatial resolution in ABI live rats (Song et al, 2021 )). The results of phantom experiments and animal experiments demonstrate that ABI is able to localize simulated current sources or firing neurons at high resolution under a variety of conditions, demonstrating the feasibility of ABI for detecting intracranial neuronal firing (Barragan et al, 2020 ). In the next study, as a transition between mimic brain tissue phantom experiments and in vivo brain experiments, we can try to use live brain slices for bio-current source imaging in in vitro experiments, which is a must before its application in the clinic.…”

Section: Research Progressmentioning

confidence: 89%

“…Because the skull is a strong absorber and disperser of ultrasound and electrical signals (Zhang et al, 2021 ), in earlier studies, the skull cap was removed and ultrasound waves were delivered directly through the surface of the brain phantom (Qin et al, 2016 ). Barragan used a head phantom with a real human skull to demonstrate 4D ABI for mapping time-varying monopoles and dipoles at depths >60 mm with detection thresholds <0.5 mA ( Figure 4 ) (Barragan et al, 2020 ). In 2022, Zhang used FUS irradiation to simulate the dipole of neuronal firing, and the simulation and experimental results showed that the localization and decoding results were highly consistent with the predicted situation (Zhang et al, 2022 )).…”

Section: Research Progressmentioning

confidence: 99%

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Biological current source imaging method based on acoustoelectric effect: A systematic review

Zhang

Liu

et al. 2022

Front. Neurosci.

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Neuroimaging can help reveal the spatial and temporal diversity of neural activity, which is of utmost importance for understanding the brain. However, conventional non-invasive neuroimaging methods do not have the advantage of high temporal and spatial resolution, which greatly hinders clinical and basic research. The acoustoelectric (AE) effect is a fundamental physical phenomenon based on the change of dielectric conductivity that has recently received much attention in the field of biomedical imaging. Based on the AE effect, a new imaging method for the biological current source has been proposed, combining the advantages of high temporal resolution of electrical measurements and high spatial resolution of focused ultrasound. This paper first describes the mechanism of the AE effect and the principle of the current source imaging method based on the AE effect. The second part summarizes the research progress of this current source imaging method in brain neurons, guided brain therapy, and heart. Finally, we discuss the problems and future directions of this biological current source imaging method. This review explores the relevant research literature and provides an informative reference for this potential non-invasive neuroimaging method.

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Section: Research Progressmentioning

confidence: 89%

Section: Research Progressmentioning

confidence: 99%

Biological current source imaging method based on acoustoelectric effect: A systematic review

Zhang

Liu

et al. 2022

Front. Neurosci.

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“…This further affirms the brain imaging capabilities of tABI. In previous studies, it has been shown that appropriately increasing the number of electrodes and choosing an appropriate electrode layout can significantly improve the signal-to-noise ratio of images [21] [25]. We will try adding electrode arrays to improve the imaging quality of tABI in future work.…”

Section: Discussionmentioning

confidence: 99%

“…Then, tABI was presented by Y. Qin et al in 2017 [6], which is like AENI but more specific in electromagnetic signal type. The feasibility of using an artificial current source for AEI in a human head model and rat hippocampus has been confirmed, and many studies have shown that tABI may be able to accurately resolve deep neuron currents with a high spatial resolution (<3mm) [17][18][19][20][21]. But these models mainly use artificial current sources to simulate neural activity and lack valuable real brain data for verification and optimization.…”

Section: Introductionmentioning

confidence: 97%

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Steady-State Visual Stimulation Paradigms

Song

Chen

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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Based on the acoustoelectric (AE) effect, transcranial acoustoelectric brain imaging (tABI) is of potential for brain functional imaging with high temporal and spatial resolution. With nonlinear and non-steady-state, brain electrical signal is microvolt level which makes the development of tABI more difficult. This study demonstrates for the first time in vivo tABI of different steady-state visual stimulation paradigms. Method: To obtain different brain activation maps, we designed three steady-state visual stimulation paradigms, including binocular, left eye and right eye stimulations. Then, tABI was implemented with one fixed recording electrode. And, based on decoded signal power spectrum (tABI-power) and correlation coefficient between steady-state visual evoked potential (SSVEP) and decoded signal (tABI-cc) respectively, two imaging methods were investigated. To quantitatively evaluate tABI spatial resolution performance, ECoG was implemented at the same time. Finally, we explored the performance of tABI transient imaging. Results: Decoded AE signal of activation region is consistent with SSVEP in both time and frequency domains, while that of the nonactivated region is noise. Besides, with transcranial measurement, tABI has a millimeter-level spatial resolution (<3mm). Meanwhile, it can achieve millisecond-level (125ms) transient brain activity imaging. Conclusion: Experiment results validate tABI can realize brain functional imaging under complex paradigms and is expected to develop into a brain functional imaging method with high spatiotemporal resolution.

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“…[2,[4][5][6] AE has been recently used to realize the acoustoelectric imaging (AEI) of biological tissue which has been successfully applied for breast cancer detection, [7] cardiac imaging, [8][9][10][11][12][13] and mapping deep brain stimulation (DBS) currents during transcranial brain imaging. [14][15][16][17][18][19] In parallel, in recent years low-density focused ultrasound (LIFU) has been studied as an alternative novel non-invasive brain stimulation technique. [20,21] It safely induces reversible AE in biological tissues and possesses dual advantages of exquisite spatial specificity and deep penetration.…”

Section: Introductionmentioning

confidence: 99%

Wideband frequency-dependent dielectric properties of rat tissues exposed to low-intensity focused ultrasound in the microwave frequency range

Wang¹,

Jiang²,

Huang³

et al. 2023

Chinese Phys. B

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Tissue dielectric properties can vary upon the incident of an acoustic wave. The goal of this study is to quantify this change due to the acoustoelectric effect (AE), and to obtain the frequency-dependent dielectric properties of tissues exposed to low-intensity focused ultrasound (LIFU). The dielectric properties of the blood, brain, chest muscle, heart, kidney, leg muscle, liver, lung, pancreas, and spleen of rats were measured by an open-ended coaxial probe method. The acoustic intensity of LIFU focus was 2.97 MPa (67.6 W/cm2), 3.95 MPa (120 W/cm2), and 5.17 MPa (204 W/cm2), respectively, and the measurement frequency band was 0.1–7.08 GHz. The measurement results show that with the LIFU modulation, the conductivity and dielectric constant decreased in the high-frequency band, and on the contrary, they increased in the low-frequency band, and the larger the acoustic intensity was, the more obvious the phenomenon was. This work contributes to a better understanding of the mechanisms by which ultrasound acts on the dielectric properties of biological tissues. It is expected that the findings from this study will provide a basis that the response of tissue to LIFU modulation can be monitored by noninvasive techniques such as microwave-induced thermoacoustic imaging (MTI) and microwave imaging, present a new idea for improving the endogenous contrast between different biological tissues in MTI and acoustoelectric imaging, and possibly lead to the development of a new imaging method based on the relaxation time of tissue after LIFU modulation.

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Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy

Cited by 20 publications

References 26 publications

Biological current source imaging method based on acoustoelectric effect: A systematic review

Biological current source imaging method based on acoustoelectric effect: A systematic review

In Vivo Transcranial Acoustoelectric Brain Imaging of Different Steady-State Visual Stimulation Paradigms

Wideband frequency-dependent dielectric properties of rat tissues exposed to low-intensity focused ultrasound in the microwave frequency range

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